Microwave-assisted preparation of nucleoside-phosphoramidites.

Microwave-assisted phosphitylation of sterically hindered nucleosides is demonstrated to be an efficient method for the preparation of corresponding phosphoramidites (otherwise onerous under standard conditions) and is shown to be general in its applicability.

[Madelung's disease and lesions of the extensor tendons. A case report]. / Maladie de Madelung et lésions des tendons extenseurs. A propos d'une observation.

A case of incomplete rupture of the extensor tendon to the little finger is reported in a 64-year-old woman with an idiopathic Madelung's deformity which had been present since adolescence but had given rise to no problems. Surgical treatment by resection of the head of the ulna with fixation of the ulna to the radius gave a satisfactory result. Only two similar case reports of rupture of extensor tendons associated with Madelung's deformity have been published. In spite of its rarity, this complication deserves to be known and possibly prevented by resection of the head of the ulna when it is very prominent. It should be recognized before any loss of extension of the little finger, however slight, develops. Lesions of extensor tendons in contact with an excessive prominence of the head of the ulna are among the best known complications of rheumatoid arthritis. Occasionally, the same type of lesion can be seen in Madelung's deformity.

[Practitioner facing depression (author's transl)]. / Un praticien face à la dépression.

The author underlines how important it is not to neglect an organical illness, particularly if the patient is of age since it is easy to diagnosticate a depression. He enumarates the various complementary examinations which, combined to a clinical one would allow to reject an organical cause.