RESUMEN
Homogenous allocation of inorganic particles in a polymeric matrix is a challenge. In this work, we discuss electrospinning of chitosan /gelatin using CS-Si (chitosan silicone hybrids) as well as the formation of homogeneously distributed Zn elements inside chitosan nanofiber through chitosan -GPTMS hybrids. Chitosan -GPTMS hybrids can be synthesized by acid catalyzed amino-oxirane addition reaction. The proposed mechanism was approved by using spectral and elemental analyses. The chitosan derivative Si-Cs was mixed with gelatin and their solution were applied to electrospinning. Optimization of spinning process is reached. A homogeneous spinnable solution with desirable properties is obtained by addition of Zinc acetate. The characterizations of the spinnable solution in term of electrical conductivity and viscosity were studied. Characterization of the nanofiber formed by SEM show that there is no Zn accumulated on the nanofiber surfaces which is one of the advantages of introducing GPTMS to Cs chain. The superior antibacterial activity of the produced zinc-containing electrospun fibers of Gelatin-Si-Cs nominate it to be applied for medical purpose.
Asunto(s)
Antibacterianos/química , Antibacterianos/farmacología , Quitosano/química , Quitosano/farmacología , Electricidad , Gelatina/química , Zinc/química , Antibacterianos/síntesis química , Técnicas de Química Sintética , Quitosano/síntesis química , Nanofibras/química , Siliconas/química , Solventes/químicaRESUMEN
A novel method for preparation of a conducting nanometal hydroxide hydrogel was undertaken. In situ accommodation of metal hydroxide nanoparticles within swollen hydrogel networks is developed. Thus, poly(acrylic acid/acrylate) hydrogel (PAAc/AC) was prepared by simultaneous polymerization of acrylic acid/acrylate (AAc/AC). Electrodeposition hydroxide of nanoiron and nanocopper into (PAAc/AC) hydrogel was performed. Swelling behaviour and swelling kinetics of prepared hydrogel were evaluated in media having different pH values. The conductivity of both PAAc/AC/nanocopper hydroxide and PAAc/AC/nanoiron hydroxide were measured in comparison with that for PAAc/AC hydrogel. An amelioration in conductance of PAAc/AC hydrogel having 0.8×10(3)µS after being incorporated with nanocopper hydroxide and nanoiron hydroxide to be 1.5×10(3)µS and 2.6×10(3)µS, respectively has been achieved. Distribution of the metal hydroxide nanoparticles penetrated within the hydrogel networks using transmission electron microscopy has been thoroughly elucidated.
