Forward stroke volume is predictor of perioperative course in patients with mitral regurgitation undergoing mitral valve replacement.

BACKGROUND: Decreased left ventricle ejection fraction (LVEF) is a predictor of poor late outcome in patients with mitral regurgitation (MR). The relationship between pre-operative forward stroke volume (SV) and right heart parameters and perioperative outcome in patients with MR has been little studied. METHODS: Forty patients with severe organic MR, unsuitable for mitral valve repair, who underwent mitral valve replacement (MVR) were included in the study (50% men, average age 61 +/- 9 years). Exclusion criteria were: aortic valve disease, coronary artery disease, rethoracotomy, stroke, infection or significant perioperative bleeding. Pre-operative detailed echocardiographic examination was performed. The end-point was post-operative prolonged intensive care unit (ICU) stay of more than three days because of the need for inotropic support. RESULTS: Pre-operative NYHA class was 2.6 +/- 0.4, mean right ventricular end-diastolic diameter (RVEDD) was 28.7 +/- 4 mm, TAPSE was 20 +/- 4 mm, mean right ventricular systolic pressure (RVSP) was 38 +/- 13 mm Hg, left ventricular end-systolic diameter was 43.5 +/- 11 mm, left ventricular end-diastolic diameter was 60 +/- 11 mm, left ventricular end-diastolic volume (Simpson) was 155 +/- 47 mL, LVEF was 55 +/- 11%, mean regurgitation fraction was 58% and forward SV (measured by Doppler) was 35 +/- +/- 11 mL. All patients survived the operation. Mean ICU stay was 3.2 +/- 2.9 days (range 1-10 days), mean TISS-28 was 623 +/- 293 and mean NEMS 151 +/- 85. By univariate analysis, ICU stay was significantly longer in patients in higher pre-operative NYHA (p = 0.04), lower LVEF (p = 0.01), lower forward SV (p = 0.001) higher RF (p = 0.01), pre-operative right ventricular dilatation (p = 0.04), higher RVSP (p = 0.006) and right ventricular dysfunction (p = 0.04). By multivariate analysis, forward SV (p = 0.002, b = -0.45) and RVEDD (p = 0.02, b = 0.31) were independent predictors for prolonged ICU stay. CONCLUSIONS: Pre-operative forward stroke volume and right ventricle size are predictors of the perioperative hemodynamic status in patients with mitral regurgitation undergoing MVR.

Stenotrophomonas maltophilia pacemaker endocarditis in a patient with d-transposition of the great arteries after atrial switch procedure.

We report a case of pacemaker endocarditis due to Stenotrophomonas maltophilia in a 22-year-old Caucasian man with d-transposition of the great arteries after atrial switch procedure. S.maltophilia isolated from blood cultures was susceptible to trimethoprim-sulfamethoxazole and amikacin, and resistant to ciprofloxacin and all tested ß-lactam antibiotics. The infected pacemaker system was completely removed by thoracotomy. Simultaneously, a new DDD pacemaker and epicardial electrodes were successfully implanted and selective antibiotic therapy consisting of trimethoprim-sulfamethoxazole (480 mg i.v. q 6 h) and amikacin (250 mg i.v. twice daily) was continued. However, the post-operative course was complicated by septic shock and the patient died on 9th day after surgery. Importantly, S.maltophilia isolated from extracted pacemaker leads was multidrug-resistant including to trimethoprim-sulfamethoxazole, ciprofloxacin, all tested aminoglycosides, and ß-lactams, with the exception of ticarcillin-clavulanate. In conclusion, pacemaker endocarditis due to Stenotrophomonas maltophilia is an extremely rare but serious complication of permanent pacing therapy. The susceptibility of S.maltophilia isolates to antimicrobial agents can change during the course of infection. Despite the inherent resistance of S.maltophilia to most ß-lactam antibiotics, multidrug-resistant strains may be susceptible in vitro to ticarcillin-clavulanate. Further studies are needed to determine the optimal management of patients with pacemaker endocarditis caused by Stenotrophomonas maltophilia.

Preoperative right ventricular function in patients with organic mitral regurgitation.

AIMS: To assess the right ventricular (RV) function in patients with severe mitral regurgitation (MR); to find a relation between preoperative and postoperative parameters. METHODS: RV function was echocardiographically assessed by determining the tricuspid annular plane systolic excursion (TAPSE) and the peak systolic velocity of the lateral tricuspid annulus (Sa) in 45 patients with severe organic MR (53.3% men, age 58 +/- 10 years). Mean NYHA class was 2.6 +/- 0.4, LVEF was 55.3 +/- 12%, RV end-diastolic diameter was 28.7 +/- 4.7, left ventricular end-systolic diameter (LVESD) was 44.6 +/- 12.6 mm, and LV end-diastolic volume (Simpson) was 160.6 +/- 50.3 ml. All patients underwent mitral valve replacement with posterior chordal sparing. RESULTS: Mean preoperative TAPSE and Sa were 19.4 +/- 4.3 mm and 10.3 +/- 3 cm/sec, respectively. RV dysfunction, defined as TAPSE < 22 mm, had 66.6% of the patients, and Sa < 11 cm/sec was found in 62.2% of the patients preoperatively. Preoperative TAPSE and Sa were significantly correlated (P < 0.00001, r = 0.61). Both TAPSE and Sa were correlated with the RV end-diastolic diameter (P < 0.01), LVESD (P < 0.05) left ventricular dp/dt (P < 0.05), and LVEF (P < 0.0001). Postoperative LVEF was 50% (P < 0.001), Sa 5.3 +/- 2 cm/sec (P < 0.001), and TAPSE 8.7 +/- 3.2mm (P < 0.001). Twenty-one patients (46.6%) reached the study end point of decrease of LVEF by more than 10%. Univariate predictors were age (P = 0.04), male gender (P = 0.01), TAPSE (P = 0.007), and Sa (P = 0.009), while a trend was found for regurgitation fraction (P = 0.058) and LV end-diastolic volume index (P = 0.09). By multivariate analysis, TAPSE (P = 0.01) and Sa (P = 0.01) were predictive for the study end point. CONCLUSION: The assessment of the RV function by echocardiography is a simple tool that provides prognostic information in patients with MR.

Comparison of the efficacy and safety of pharmacological treatment versus percutaneous coronary angioplasty in patients with intermediate coronary artery lesions.

BACKGROUND: It is unclear if patients with intermediate coronary artery lesions (40-70% of diameter reduction) benefit from percutaneous coronary intervention (PCI) as compared with pharmacological treatment. AIM: To investigate whether PCI of intermediate coronary artery lesions may improve the outcome in this group of patients. METHODS: We performed a retrospective analysis of data of 232 symptomatic patients with intermediate coronary lesions. Hundred sixty five patients received only pharmacological treatment (group A) while 67 were treated with PCI with or without stent implantation (group B). Primary study endpoints were defined as follows: death (cardiac and non-cardiac), myocardial infarction, unstable angina, recurrent angina and coronary reintervention. Demographic and clinical variables were evaluated to identify predictors of the composite endpoint (exacerbation of angina, hospitalisation because of severe angina, restenosis in the intermediate coronary lesion, acute coronary syndrome and cardiac death). RESULTS: In group A, patients were treated with typical pharmacotherapy including beta-blockers, Ca-blockers, ACE-inhibitors, and antiplatelet drugs. In group B, 68 PCI procedures were performed in 67 patients and optimal pharmacotherapy was administered. The average age of patients in both groups was 58.0 +/- 9.1 years and the majority were males (76%). Preinterventional coronary angiography showed that the intermediate lesions were most frequently localised in the left anterior descending (LAD) coronary artery; the next most frequent localisation was the right coronary artery (RCA). During the 12-month follow-up in 9 (13%) patients from the group B repeated PCI due to restenosis was performed, while in group A intervention was necessary in 7 (4%) of patients due to aggravation of symptoms (p = 0.01). The cumulative probability of restenosis after PCI in intermediate coronary lesions was 14%. Recurrent angina was more frequent in group B as compared to group A (34 vs. 19%; p = 0.005). None of the patients in any group died during 12 months of follow-up. In patients with intermediate coronary lesions, the independent predictors of the composite study endpoint were: history of previous percutaneous coronary angioplasty, type 2 diabetes, persistent ST-segment elevation in 12-lead ECG, heart rhythm disturbances, presence of the intermediate lesion in the LAD, and left ventricular dysfunction. CONCLUSIONS: Patients with intermediate coronary artery stenoses could safely undergo pharmacological treatment and PCI may be postponed until aggravation of symptoms occurs. In the presence of predictors of the composite study endpoint, the use of intracoronary diagnostic methods may be considered to obtain more reliable and precise measurements of coronary stenosis severity.

[Lyme carditis presenting as acute coronary syndrome: a case report]. / Boreliozowe zapalenie serca manifestujace sie jako ostry zespól wiencowy.

A case of a 26-year-old man with Lyme carditis (LC) mimicking acute coronary syndrome is presented. Considering clinical presentation, electrocardiographic findings and markedly elevated levels of cardiac biomarkers, emergency coronary angiography was performed and revealed normal coronaries. Ventricular arrhythmias of Lown grade IVb during catheterization were recorded. Echocardiography showed mild global left ventricular dysfunction with ejection fraction of 50%. The diagnosis of LC was confirmed by ELISA and Western blot serologic testing. After 21 days of continuous antibiotic therapy with ceftriaxone (2.0 g/d) the patient recovered completely. We also present the current state of knowledge on the cardiovascular aspects of Lyme borreliosis.

Patency of infarct related artery after pharmacological reperfusion during transfer to primary percutaneous coronary intervention influences left ventricular function and one-year clinical outcome.

BACKGROUND: Time-to-treatment is an important determinant of mortality in primary angioplasty for ST-segment elevation myocardial infarction (STEMI). Thus, the benefits in outcome observed with transferring for primary angioplasty in comparison with on-site thrombolysis may be reduced or even lost when long-distance transportation is required. Even though pharmacological reperfusion might overcome this limitation, no data have been reported so far on the prognostic role of early pharmacological recanalization in STEMI patients undergoing long-distance transportation for primary angioplasty. METHODS: We enrolled 225 consecutive STEMI patients without shock, eligible for thrombolysis, with at least 90-minute transport time to our primary PCI center. During transport, patients received i.v. heparin 40 U/kg, alteplase 15 mg+35 mg infusion and abciximab 0.25 mg/kg+0.125 microg/kg/min infusion for 12 h. RESULTS: Patients were divided into two groups according baseline angiography, which showed early pharmacological reperfusion (preprocedural TIMI flow 2+3) in 193 patients (85.8%) and no reperfusion (preprocedural TIMI flow 0+1) in 32 patients (14.2%). Despite no difference in postprocedural TIMI flow, early reperfusion was associated with better postprocedural myocardial perfusion (TMPG 3: 54.9% vs. 18.7%, p<0.0001), better improvement in left ventricular ejection fraction (LVEF) (from 55.6+/-8.6% to 58.8+/-10.4% p<0.001 with early reperfusion vs. 52.9+/-13.4% to 50.4+/-15.8% with no early reperfusion, p=NS) and 1-year outcome (p=0.002 log rank). In multivariate analysis, preprocedural TIMI flow 0+1 independently predicted death and reinfarction at 1 year, and lack of LVEF improvement at 6 months. CONCLUSIONS: Early pharmacological reperfusion in STEMI patients undergoing long-distance transportation for primary angioplasty is associated with better postprocedural myocardial perfusion, better LVEF recovery at 6 months and improved 1-year clinical outcome.

[Recurrence of tricuspid regurgitation in a patient with a rheumatic fever after mitral valve implantation with concomitant tricuspid valve annuloplasty]. / Ponowna niedomykalnosc zastawki trójdzielnej u chorej po operacji wszczepienia zastawki mitralnej i jednoczesnej plastyce zastawki trójdzielnej w przebiegu goraczki reumatycznej.

A case of a 62-year-old female with a recurrence of tricuspid regurgitation is presented. This complication occurred after mitral valve implantation and tricuspid valve annuloplasty. Diagnosis and treatment of this condition following rheumatic fever are discussed.

N-terminal pro-brain natriuretic peptide level in relation to epicardial and myocardial reperfusion in ST-segment elevation myocardial infarction treated with facilitated angioplasty.

UNLABELLED: The aims of this study were firstly to evaluate the relations between N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration after ST-segment elevation myocardial infarction (STEMI) and reperfusion injury, and secondly to assess the prognostic value of NT-proBNP. METHODS AND RESULTS: We evaluated 202 consecutive patients with STEMI treated with facilitated angioplasty (PCI). TIMI flow, TIMI myocardial perfusion grade (TMPG) and ST-segment elevation resolution (iST) were assessed before O and 30 minutes (O30) after PCI. Enzymatic injury was expressed as an area under the curve of CK-MB release (AUC, [Uxh]). 48 hours after PCI, the concentration of NT-proBNP ([pg/ml]) and echocardiography-determined left ventricle ejection fraction (LVEF, [%]) were assessed. Death and heart failure (HF) requiring hospitalisation were recorded during a 1-year follow-up and defined as a composite endpoint. NT-proBNP concentration 48 hours after PCI was correlated with iST-O (p<0,001; r=0,48), iST-O30 (p<0,001; r=0,57), AUC (p<0,001; r=0,54) and LVEF (p<0,001; r=-0,5). Increasing quartiles of NT-proBNP were related to mortality (p=0,0012) as well as to composite endpoint (p=0,0012) at 1 year. 4th-quartile of NT-proBNP was independently associated with a composite endpoint at a 1-year follow-up. CONCLUSIONS: NT-proBNP level after STEMI was moderately correlated with the degree of microvascular reperfusion and myocardial injury and function. NT-proBNP was independently associated with the frequency of death and HF requiring hospitalisation.

[Acute coronary syndrome or perimyocarditis?--case report]. / Ból w klatce piersiowej u 25-letniego chorego -- ostry zespól wiencowy czy zapalenie miesnia sercowego i osierdzia? Opis przypadku.

Acute coronary syndrome or perimyocarditis? A case report. A case of a 25-year-old male with a severe chest pain associated with ST segment changes, elevated serum C-reactive protein, myocardial necrosis markers and normal epicardial coronary arteries is presented. The patient recently recovered from upper respiratory infection. Differential diagnosis between acute coronary syndrome and perimyocarditis is discussed.

[Abscess of the mitral annulus mimicking left atrial tumour - case report]. / Ropien pierscienia zastawki mitralnej imitujacy guz lewego przedsionka. Problem diagnostyczny.

A case of a 70-year-old female with hypertension, atrial fibrillation and angina pectoris, admitted to the hospital due to echocardiographically detected left atrial tumour, is presented. Differential diagnosis included thrombus, myxoma, infectious or neoplastic tumour. The patients underwent surgery. Histopathological examination revealed the presence of an abscess in the left atrium. This report underlines the difficulties in the diagnosis of cardiac tumours.

[Multiple thrombo-embolic episodes in a patient with alcoholic cardiomyopathy - a case report]. / Mnogie zatory tetnicze u chorego naduzywajacego alkohol etylowy.

A case of 42-year-old male with alcoholic dilated cardiomyopathy is presented. The patient was admitted to the hospital due to new onset heart failure and neurological symptoms due to systemic emboli. Transesophageal echocardiography revealed the presence of left atrial appendage thrombi which were the most probable cause of thrombo-embolic complications.