Topological signatures in the entanglement of a topological insulator-quantum dot hybrid.

In the present work, we consider a hybrid plexciton composed of a semiconductor quantum dot interacting with a topological insulator nanoparticle subject to an external magnetic field. Due to the topological magnetoelectricity of the nanoparticle, long-living plasmonic surface modes are induced, which are quantized and coupled with the quantum dot through its polarization operator. We consider the hybrid as an open quantum system, such that environment effects are accounted by the master equation in the Born-Markov approximation. Then, we apply the Peres' positive partial transpose criterion to quantify the entanglement of the hybrid. We show that this entanglement is a direct signature of the [Formula: see text] invariant of topological insulators.

A Case Report about Glycogenic Hepatopathy.

Introduction: Glycogenic hepatopathy is a rare complication of uncontrolled diabetes mellitus that presents with hepatomegaly and transient elevation in serum aminotransferase enzymes. The underlying pathophysiology involves excessive accumulation of intrahepatic glycogen. Glycogenic hepatopathy is usually underdiagnosed because it is difficult to differentiate from other entities, such as the nonalcoholic fatty liver. The gold standard for diagnosis is liver biopsy. Glycogenic hepatopathy can be reversed by the achievement of adequate glycemic control. Case description. A 19-year-old female patient with a history of poorly controlled type 1 diabetes mellitus that resulted in several episodes of diabetes ketoacidosis requiring hospital admissions. The patient presented to the emergency room with generalized weakness and fatigue found to have diabetic ketoacidosis. Blood tests revealed abnormal liver function with aspartate aminotransferase 1129 U/L (13-37 U/L), alanine aminotransferase 766 U/L (13-56 U/L), alkaline phosphatase 216 U/L (45-117 U/L), total bilirubin 1.0 mg/dL (0.2-1.3 mg/dL), albumin 3.8 g/dL (3.4-5.0 g/dL), partial thromboplastin time < 20 s (23-31 s), prothrombin time 11.8 s (9.5-11.5 s), and international normalized ratio 1.1. Acute hepatitis serologies were negative. Epstein-Barr virus and cytomegalovirus were ruled out. Extensive autoimmune hepatitis tests were negative. Primary biliary cirrhosis was also ruled out. A liver biopsy was obtained, which was diagnostic of glycogenic hepatopathy. Conclusion: Glycogenic hepatopathy must be suspected in patients with uncontrolled type 1 diabetes mellitus who present with elevated liver enzymes and hepatomegaly. Treating this rare condition requires a timely diagnosis with liver biopsy and strict glycemic control.

Use of three-dimensional computational fluid dynamics model for a new configuration of circular primary settling tank.

Appropriately used, computational fluid dynamics models are powerful tools to design and optimize primary settling tanks (PSTs). This paper uses a Fluent-based 3D model to identify the possible causes for underperformance of the circular PSTs at the Cali waste-water treatment plant, Colombia, and to propose design modifications to improve performance. A new configuration for the center well (CW) is proposed and evaluated. The influence of a rotational sludge scraper and of continuous sludge removal were considered in the numerical simulation. The new configuration included the modification of the current CW diameter and the location of a second baffle with the CW. The results suggest that the installation of the second baffle allows a more uniform flow distribution within the PST and consequently, the hydrodynamic problems associated with short-circuiting of the influent to the bottom of the tank are reduced. The second baffle suppresses the downward current, effectively dissipates the kinetic energy in the influent and forces the particles to move toward the bottom of the PST. In addition, the second CW baffle allows the formation in the inlet zone of a consistently more concentrated sludge blanket layer and thicker sludge, reducing the risk of solids leaving in the effluent of the PST.

Diagnostic performance of 18F-choline PET-CT in prostate cancer.

OBJECTIVES: To evaluate the diagnostic performance of 18F-choline PETCT in staging prostate cancer (PC) and whether the use of this imaging modality changes the therapeutic decision in patients previously staged by conventional imaging. The secondary aim was to determine the prognostic factors associated with positive choline PETCT findings in both detection of disseminated disease and in changes in the therapeutic indication. MATERIALS AND METHODS: Multicentre, retrospective, observational study of 269 patients diagnosed with PC. Mean age was 69 ± 9.2 years. Of the 269 patients, 62 (23%) had high-risk localized PC (group 1), 118 (43.9%) biochemical failure after radical prostatectomy (group 2), and 89 (33.1%) biochemical failure after radiotherapy (group 3). None of the patients showed clear evidence of distant disease on computed tomography or bone scans. The following potential prognostic factors were assessed: PSA level at diagnosis; primary and secondary Gleason; Gleason score (GS); clinical and pathologic T and N stage; number of positive cylinders in the biopsy; presence of vascular or lymphatic invasion; status of surgical margins; androgen deprivation therapy (ADT); time to biochemical recurrence; and PSA, PSA doubling time (PSADT), and PSA velocity (PSAV) at failure. Univariate and multivariate analyses were performed, and receiver-operating curves calculated. RESULTS: The mean PSA by groups was, group 1: 31.22 ng/ml, group 2: 2.52 ng/ml and group 3: 5.85 ng/ml. The tumor detection rate with 18F-choline PETCT was 74% (group 1: 85.5%, group 2: 55.1% and group 3: 91%). Prognostic factors for positive 18F-choline PETCT were identified only in group 2: PSA at failure and PSADT. 18F-choline PETCT changed the therapeutic indication in 62.8% (group 1: 71%, group 2: 55.2% and group 3: 70.1%). The prognostic factors for a change in treatment were identified only in group 1: secondary Gleason ≤ 4 and GS ≤ 7 and in group 2: PSA at failure, PSA nadir after surgery and pathologic stage N0. 18F-choline PETCT identified lymph node and/or metastatic disease in 32.7% (group 1: 25.8%, group 2: 29.7% and group 3: 41.6%). Prognostic factors for detecting lymph node/metastasis were identified in the group 2: PSA failure ≥ 1.37 ng/ml and PSADT < 4 months and in the group 3: PSADT < 4.6 months and time to failure < 5 years. CONCLUSION: These findings support the clinical use de 18F-choline PET-CT in staging high-risk patients with a secondary Gleason ≤ 4 and GS ≤ 7, in restaging patients with biochemical recurrence after RP if PSA at failure ≥ 1.37 ng/ml or PSADT ≤ 4 months and in patients with biochemical failure after RT, if PSADT ≤ 4.6 months and time to failure < 5 years, because it determines a change in the therapeutic indication.

Scanning electron microscopy of bacteria Tetrasphaera duodecadis.

This study reports the characterization of the Tetrasphaera duodecadis bacteria and the techniques used therein. In order to evaluate the morphological characteristics of the T. duodecadis bacteria scanning electron microscope (SEM) was used throughout its different growth stages. These microorganisms were grown in vitamin B12 broths with 1% tryptone, 0.2% yeast extract, and 0.1% glucose. The turbidimetric method was employed for the determination of bacterial concentration and growth curve. The SEM results show small agglomerates of 0.8 ± 0.05 µm during the lag phase, and rod-like shapes during the exponential phase with similar shapes in the stationary phase.

smcL as a novel diagnostic marker for quantitative detection of Listeria ivanovii in biological samples.

AIMS: To develop a novel molecular tool for the quantitative detection of the ruminant pathogen Listeria ivanovii in different biological matrices. METHODS AND RESULTS: A real-time PCR (RTi-PCR) for the quantitative and species-specific identification of L. ivanovii was designed to target the region of the smcL gene. The assay includes an internal amplification control (IAC) to avoid false-negative results. The smcL-IAC RTi-PCR assay was 100% selective and allowed the detection of as little as one genome equivalent in 45% of reactions. The quantification accuracy was excellent, as demonstrated by its high linearity (R(2)>0·9989) and PCR efficiency (E>0·984) over a 6-log dynamic range, down to 10 genome equivalents. Finally, the applicability of this assay was evaluated with artificially contaminated biological matrices implicated in the transmission of this bacterium such as sheep raw milk, blood and amniotic fluid. The smcL-IAC RTi-PCR assay allowed the detection of as few as 50 colony forming unit numbers (CFUs) per 25 ml of raw milk, 43 CFUs per 1 ml of blood or 50 CFUs per 1 ml of amniotic fluid. CONCLUSIONS: This method can be an adequate alternative for the identification of L. ivanovii and for complete diagnosis of animal and human listeriosis. significance and impact of the study: We present an alternative for the detection of another pathogenic member of Listeria genus, which can help to distinguish from Listeria monocytogenes and therefore facilitates the establishment of preventive and prophylactic measures in food and farm environments.

Point-of-care coagulation testing and transfusion algorithms.

Patients with cardiovascular disease have an array of haemostasis disorders that predispose to the development of thrombotic and embolic disease states. These patients are often maintained on anti-thrombotic medication to prevent adverse cardiovascular events. Patients undergoing cardiac surgery also have haemostatic disorders that include their intrinsic disease state, adjunctive medication, and the coagulation disturbances induced by cardiopulmonary bypass. The following review introduces the monitors that are available for monitoring perioperative coagulation, with an emphasis on cardiovascular surgery. Heparin monitors, platelet function monitors for use in transfusion algorithms, and monitoring anti-platelet drugs will be discussed.

Nutrients removal in hybrid fluidised bed bioreactors operated with aeration cycles.

Abstract Two hybrid fluidised bed reactors filled with sepiolite and granular activated carbon (GAC) were operated with short cycled aeration for removing organic matter, total nitrogen and phosphorous, respectively. Both reactors were continuously operated with synthetic and/or industrial wastewater containing 350-500 mg COD/L, 110-130 mg NKT/L, 90-100 mg NH3-N/L and 12-15 mg P/L for 8 months. The reactor filled with sepiolite, treating only synthetic wastewater, removed COD, ammonia, total nitrogen and phosphorous up to 88, 91, 55 and 80% with a hydraulic retention time (HRT) of 10 h, respectively. These efficiencies correspond to removal rates of 0.95 kgCODm(-3)d(-1) and 0.16 kg total N m(-3)d(-1). The reactor filled with GAC was operated for 4 months with synthetic wastewater and 4 months with industrial wastewater, removing 98% of COD, 96% of ammonia, and 66% of total nitrogen, with an HRT of 13.6 h. No significant phosphorous removing activity was observed in this reactor. Microbial communities growing with both reactors were followed using polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE) techniques. The microbial fingerprints, i.e. DGGE profiles, indicated that biological communities in both reactors were stable along the operational period even when the operating conditions were changed.

Aneurisma cirsoideo yeyunal como causa de hemorragia digestiva baja exanguinante / Jejunal cirsoid aneurysm as a cause of massive lower gastrointestinal bleeding: report of one case

El aneurisma cirsoideo o lesión de Dieulafoy es una causa infrecuente de hemorragia digestiva. Corresponde a una malformación vascular que puede presentarse en cualquier zona del tubo digestivo, su localización más frecuente es en el estómago proximal, siendo excepcional en el intestino delgado. Se puede manifestar clínicamente como una hemorragia digestiva masiva o exanguinante. El objetivo es presentar un caso clínico de una paciente de género femenino, 19 años, que debuta con una hemorragia digestiva baja exanguinante. Se realizó manejo del shock hipovolémico y angiografía de urgencia que demostró origen del sangrado en yeyuno proximal. Se realizó laparotomía de urgencia, se localizó la lesión y se realizó resección intestinal mínima del yeyuno proximal. A la macroscopia se sospechó aneurisma cirsoideo, que se confirmó con el estudio histopatológico. La paciente evolucionó satisfactoriamente y en el seguimiento alejado no presentó complicaciones. Se presenta caso clínico por tratarse de una etiología extremadamente infrecuente de hemorragia digestiva baja exanguinante y por la localización excepcional de la lesión.