Assessing the implementation of user-centred design standards on assistive technology for persons with visual impairments: a systematic review.

Despite scientific and technological advances in the field of assistive technology (AT) for people with visual impairment (VI), technological designs are frequently based on a poor understanding of the physical and social context of use, resulting in devices that are less than optimal for their intended beneficiaries. To resolve this situation, user-centred approaches in the development process of AT have been widely adopted in recent years. However, there is a lack of systematization on the application of this approach. This systematic review registered in PROSPERO (CRD42022307466), assesses the application of the ISO 9241-210 human-centred design principles in allegedly "user-centred designed" AT developments for persons with VI (see Supplementary PROSPERO Protocol). The results point to a wide variation of the depth of understanding of user needs, a poor characterization of the application of the User Centred Design (UCD) approach in the initial design phases or in the early prototyping, and a vague description of user feedback and device iteration. Among the principles set out in ISO 9241-210, the application of 5.6: "the design team includes multidisciplinary skills and perspectives" is the one for which the least evidence is found. The results show there is not enough evidence to fully assess the impact of UCD in (1) promoting innovation regarding AT products and practices, and (2) Judging if AT produced following such standards is leading to better user access, wellbeing outcomes and satisfaction. To address this gap it is necessary to, first, generate better implementation of UCD in AT development and second, to strengthen evidence regarding the implementation and outcomes of using UCD for AT. To better engage with the realities of persons with VI, we propose capacity building across development teams regarding UCD, its principles and components; better planning for UCD implementation; and cross-fertilization across engineering disciplines and social and clinical science. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=307466 PROSPERO (CRD42022307466).

Endoparasites Infecting Domestic Animals and Spectacled Bears (Tremarctos ornatus) in the Rural High Mountains of Colombia.

This research described the co-infection prevalence of endoparasites in Tremartus ornatus and domestic animals in the rural high mountains of Colombia by copro-parasitological examination. Some parasites have a zoonotic potential in wild endangered species and domestic animals in Colombian regions. T. ornatus had a notable infection with Eimeria spp., Ascaris spp., Ancylostoma spp., and Baylisascaris spp. Cryptosporidium spp., Balantidium coli, Anoplocephala spp., and Acanthamoeba spp. In B. taurus, Eimeria spp. is coinfecting with Cryptosporidium spp. (6.6%) and represents 18% of the total parasitism. In E. caballus and B. taurus. Eimeria spp. coinfecting (34.7%), with the Strongylus spp. (21.9-25%). In T. ornatus, Eimeria spp. is coinfecting with Ancylostoma spp. (36.2%), Cryptosporidium spp., Ascaris spp., Baylisascaris spp., and B. coli.

Polycystic ovarian syndrome: signs and feedback effects of hyperandrogenism and insulin resistance.

Polycystic ovary syndrome (PCOS) is a disease whose diagnosis is based on the detection of hyperandrogenism (HA) and ovulatory dysfunction. Women with PCOS frequently develop insulin resistance (IR), which generates a metabolic condition that involves a decrease in the action of insulin at the cellular level and is linked to compensatory hyperinsulinemia (HI). In PCOS, the ovary remains sensitive to the action of insulin. Additionally, it has been observed that the main effect of insulin in the ovary is the stimulation of androgen synthesis, resulting in HA, one of the fundamental characteristics of the PCOS. In this sense, the excess of androgens favors the development of IR, thus perpetuating the cycle of IR-HI-HA, and therefore PCOS. Moreover, mitochondrial dysfunction is present in PCOS patients and is a common feature in both IR and HA. This review places electron transfer as a key element in HA and IR development, with emphasis on the relationship between androgen biosynthesis and mitochondrial function. Indeed, metformin has been involved in repair mitochondrial dysfunction, decrease of oxidative stress, reduction of androgens levels and the enhancing of insulin sensitivity. Therefore, we propose that treatment with metformin could decrease HI and consequently HA, restoring, at least in part, the metabolic and hormonal disorders of PCOS.

Audiovestibular Symptoms at the Intensive Care Unit: A Narrative Review.

Vertigo, tinnitus and hearing loss are the most common audiovestibular symptoms detected in the emergency departments and outpatients settings. However, little is known about these on patients at the intensive care unit. Although these symptoms may be common in this scenario, few studies have documented their onset, triggers and other factors associated to their presentation. The evaluation of these symptoms is a challenge for intensive care unit physicians, neurologists and otolaryngologists due to several factors as consciousness, systemic comorbidities, prolonged immobility and antibiotic therapy. The frequency of audiovestibular symptoms at the intensive care unit and the related events and factors associated to their presentation will be explored in this review.

Efecto de antiparasitarios de uso común en granjas ovinas ubicadas en valledupar, cesar

Introducción: Las enfermedades parasitarias se encuentran entre las causas más frecuentes e importantes que ocasionan repercusiones sanitarias y económicas en las producciones ovinas del país. Objetivo: Determinar la efectividad de los antihelmínticos de uso común en parásitos gastrointestinales de granjas ovinas en Valledupar, Cesar. Métodos: Estudio realizado con 340 ovinos, divididos en 4 granjas (Control, Albendazol, Fenbendazol y Levamisol). Se seleccionaron ovinos con carga parasitaria moderada; se les aplicó tratamiento antihelmíntico y un muestreo postratamiento (15 días). Se evidenciaron los nematodos en estadío infectante (L3) mediante coprocultivo. Resultados: En los grupos tratados Febendazol, Albendazol y Levamisol se pudo obtener una efectividad de 44 %, 65 % y 84 %, con un límite inferior (95 %conf) de 60 %, 70 % y 86 %, respectivamente. No obstante, se evidenciaron diferencias significativas (P<0,05) en cada grupo y entre los grupos tratados. Se recuperaron larvas de Cooperia curticei, Haemonchus contortus, Strongyloides papillosus, Trichostrongylus sp. y Ostertagia sp.

Introduction: Parasitic disease are the most important and frequent cause of sanitary and economic problems in the national sheep farms. Objective: To determine the effectiveness of anthelmintics commonly used in gastrointestinal parasites from sheep farms in Valledupar, Cesar. Method: The study was realized with 340 sheep, divided into 4 farms (control, albendazole, fenbendazole, and levamisole). Sheep with a moderate parasite load were selected and treatment with an-thelmintic, post-treatment sampling was applied (15 days). Nemato-des in the infective stage (L3) were evidenced by stool culture. Results: Groups treated with fenbendazole, albendazole and levamisole had an effectivity of 44%, 65% y 84% with an inferior limit (95% conf.) of 60%, 70%, and 86%, respectively. Nevertheless, significant differences were evidenced (p < 0,05) in each group and between the treated groups. Cooperia curticei, Haemonchus contortus, Strongyloides papillosus, Trichostrongylus sp., and Ostertagia sp. larvae were found.

Efecto de antiparasitarios de uso común en granjas ovinas ubicadas en Valledupar, Cesar / Effect of commonly used antiparasitics in sheep farms located in Valledupar, Cesar, Colombia / Efeito de vermífugos comumente usados em fazendas de ovinos localizadas em Valledupar, Cesar

Introducción: Las enfermedades parasitarias se encuentran entre las causas más frecuentes e importantes que ocasionan repercusiones sanitarias y económicas en las producciones ovinas del país. Objetivo: Determinar la efectividad de los antihelmínticos de uso común en parásitos gastrointestinales de granjas ovinas en Valledupar, Cesar. Métodos: Estudio realizado con 340 ovinos, divididos en 4 granjas (Control, Albendazol, Fenbendazol y Levamisol). Se seleccionó ovinos con carga parasitaria moderada; se les aplicó tratamiento antihelmíntico y un muestreo postratamiento (15 días). Se evidenciaron los nemátodos en estadío infectante (L3) mediante coprocultivo. Resultados: En los grupos tratados Febendazol, Albendazol y Levamisol se pudo obtener una efectividad de 44%, 65% y 84%, con un límite inferior (95%conf) de 60%, 70% y 86%, respectivamente. No obstante, se evidenciaron diferencias significativas (P<0,05) en cada grupo y entre los grupos tratados. Se recuperaron larvas de Cooperia curticei, Haemonchus contortus, Strongyloides papillosus, Trichostrongylus sp. y Ostertagia sp.

Introduction: Parasitic diseases are among the most frequent and important causes that cause sanitary and economic repercussions in sheep productions in the country. Objective: To determine the effectiveness of commonly used anthelmintics on gastrointestinal parasites in sheep farms in Valledupar, Cesar. Methods: Study carried out with 340 sheep, divided into 4 farms (Control, Albendazole, Fenbendazole and Levamisole). Sheep with moderate parasitic load were selected; anthelmintic treatment and post-treatment sampling (15 days) were applied. Nematodes in the infective stage (L3) were evidenced by stool culture. Results: In the Febendazole, Albendazole and Levamisole treated groups, an effectiveness of 44%, 65% and 84% was obtained, with a lower limit (95% confidence interval) of 60%, 70% and 86%, respectively. However, significant differences (P<0.05) were evident within each group and between treated groups. Larvae of Cooperia curticei, Haemonchus contortus, Strongyloides papillosus, Trichostrongylus sp. and Ostertagia sp. were recovered.

Introdução: As doenças parasitárias estão entre as causas mais freqüentes e importantes que causam repercussões sanitárias e econômicas na produção de ovinos no país. Objetivo: Determinar a eficácia de anti-helmínticos comumente utilizados sobre parasitas gastrointestinais em criações de ovinos em Valledupar, Cesar. Métodos: Estudo realizado com 340 ovinos, divididos em 4 fazendas (Controle, Albendazole, Fenbendazole e Levamisole). Foram selecionados ovinos com carga parasitária moderada; foi aplicado tratamento anti-helmíntico e amostragem pós-tratamento (15 dias). Os nemátodos em fase infecciosa (L3) foram detectados por cultura de fezes. Resultados: Nos grupos tratados com Febendazol, Albendazol e Levamisole, foi possível obter uma eficácia de 44%, 65% e 84%, com um limite inferior (intervalo de confiança de 95%) de 60%, 70% e 86%, respetivamente. No entanto, foram evidentes diferenças significativas (P<0,05) dentro de cada grupo e entre os grupos tratados. Foram recuperadas larvas de Cooperia curticei, Haemonchus contortus, Strongyloides papillosus, Trichostrongylus sp. e Ostertagia sp.