Which of the autologous blood products administered simultaneously with arthrocentesis is more effective in terms of clinical outcomes?

This study aimed to determine which of the autologous blood products administered simultaneously with arthrocentesis is more effective on clinical outcomes in patients with temporomandibular joint disorder. The study included 116 patients who underwent arthrocentesis alone, i-PRF (injectable- Platelet Rich Fibrin) with arthrocentesis, and PRP (Platelet Rich Plasma) with arthrocentesis. A total of 35 patients underwent arthrocentesis (Group A), 47 patients underwent arthrocentesis with i-PRF (Group APRF) and 34 patients underwent arthrocentesis with PRP (Group APRP). All patients received local anaesthesia before the procedure, and then the upper joint cavity was irrigated with approximately 100 mL of saline solution. Subsequently, patients in Group APRF and Group APRP were administered 2 ml of autologous blood product. All patients' pain and maximum mouth opening values were compared statistically at each time point: before the procedure, 1 week, 1 month, 3 months, and 6 months after the procedure. The results demonstrated no significant difference among the groups in terms of pain. Nevertheless, in terms of maximum mouth opening, superior outcomes were observed in the early postoperative period in the PRP group, while superior outcomes were observed in the late postoperative period in the i-PRF group.

Is the modified double-puncture arthrocentesis technique effective in terms of clinical outcomes?

We aimed to compare the clinical results of the modified double-puncture arthrocentesis technique with the results of the conventional double-puncture and single-puncture techniques. Patients who underwent unilateral arthrocentesis and had stage 2-4 internal irregularities according to Wilkes classification were included in the study. The outcome variables were pain, maximum mouth opening, quality of life, and duration of the procedure. Data were analysed preoperatively and 1st-day, 1st-week, and 1st-month after the procedure. A total of 52 patients (49-females, 3-males) with complete records were included in this study. The mean age of the patients was 32.7 ± 15.6 years. There was no significant difference between the three techniques in terms of outcome variables at all times (p > 0.05). There was a significant difference between the single puncture technique and the other techniques in terms of procedure time (p < 0.05). No superiority of the modified double-puncture arthrocentesis was found in terms of clinical results.

How effective is a thick plate on stabilisation in 10 mm mandibular advancement?

We compared the stability and stress analysis of four different fixation methods after sagittal split ramus osteotomy (SSRO) in mandibular models. In the first model (1P1B) we adapted a four-hole, 2.0 mm standard miniplate on the osteotomy line with one bicortical screw at the top. In the second (2P) we placed two four-hole 2.0 mm standard miniplates above and below the osteotomy line. In the third (3B), we applied three inverted L-shaped bicortical screws, and in the last (1RP1B) we used a four-hole miniplate with increased thickness on the osteotomy line with one bicortical screw at the top. A static vertical load of 200 Newtons (N) was then applied to each model from the occlusal of the first molar. The maximum and minimum principal stresses on the bone were observed more in the proximal segment close to the osteotomy line in all groups. Maximum von Mises stresses were 2705.21 Megapascals (MPa), 1633.56 MPa, 1121.4 MPa, and 1734.44 MPa for the 1P1B, 2P, 3B, and 1RP1B groups, respectively. Displacement values were 1.92 mm, 1.15 mm, 0.79 mm, and 1.42 mm for the 1P1B, 2P, 3B, and 1RP1B groups, respectively. The reinforced plate contributed to the stabilisation, but it was not as effective as three bicortical screws and a double plate.

Spontaneous bone regeneration in resected non-continuous mandible due to medication-related osteonecrosis of the jaw.

Few cases of spontaneous bone regeneration after extensive resection of the jaw bone have been reported, but it is more common in young adults or children. In this case, we report spontaneous bone healing in a 73-year-old female patient. On radiological examination, necrotic regions were seen in the right mandible. She was diagnosed with medication-related osteonecrosis of the jaw due to previous bisphosphonate use. After segmental resection, stabilization achieved using a reconstruction plate. The periosteum was preserved during the procedure. Twelve months later, panoramic radiography was taken and bone formation was seen both horizontally and vertically around the plate. If the periosteum is preserved and stabilization is achieved after resection in benign lesions, the bone may regenerate spontaneously regardless of age. Therefore, instead of simultaneous autogenous bone application, such patients may be followed to determine whether spontaneous bone healing will occur. This should improve patient comfort and reduce surgical cost.

Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap and Platelet-Rich Fibrin.

PURPOSE: The aim of this retrospective study was to describe the efficacy of management of bisphosphonate-related maxillary osteonecrosis, which had resulted in an oroantral fistula formation, by performing sequestrectomy, platelet-rich fibrin (PRF) and buccal fat pad (BFP) flap. PATIENT AND METHODS: A total of 7 patients diagnosed with stage III maxillary medication-related osteonecrosis according to guidelines of the American Association of Oral and Maxillofacial Surgeons. All patients complained of persistent pain, swelling and purulent drainage with sinusitis. In order to keep the infection under control, the patients first received an antibiotic combination for 2 weeks. Then, sequestrectomy and bone debridement were performed under general anesthesia. After that, an antrectomy was performed via endoscopic sinus surgery in some cases. And the fistula was closed with BFP after or before the PRF application to the region depending on the size of the fistula. RESULTS: The fistula was successfully closed. After a mean follow-up of 16 months, no symptoms were seen in the patients. CONCLUSIONS: The patients were successfully managed with a combined treatment consisted of sequestrectomy, PRF and BFP. We suggest that large defects arose from medication-related osteonecrosis of the jaw can be managed with such a combined approach in order to lessen the recurrence risk.

A prospective split-mouth clinical study: comparison of piezosurgery and conventional rotary instruments in impacted third molar surgery.

PURPOSE: Our purpose was to compare the effects of piezosurgery and conventional rotary instruments on postoperative pain, swelling, trismus, and patients' comfort after mandibular third molar surgery. METHODS: Thirty patients (27 women and 3 men) with bilateral impacted mandibular third molars were included in this split-mouth clinical study. Sixty impacted third molars were divided into a control group (n = 30), in which the osteotomies were performed using a conventional rotary handpiece technique and an experimental group (n = 30), in which the osteotomies were done by piezosurgery technique. Duration of the procedure was recorded. Postoperative pain was assessed using a visual analogue scale (VAS). All the patients were given a form containing verbal rating scale for evaluating the swelling. Trismus was evaluated using a caliper at maximum mouth opening (cm). In postoperative seventh day, patients were asked to fill a global quality of life (QoL) scale as well. RESULTS: There was no significant difference in postoperative pain, trismus, and swelling between control and experimental groups (p > 0.05). However, time of the procedure increased in control group (p < 0.05). CONCLUSION: Piezosurgery is a safe way for performing the osteotomies during third molar surgery. However, regarding the postoperative morbidity, it does not have an advantage over conventional rotary instruments. Piezosurgery took longer to complete the osteotomy than the rotary handpiece technique.

Evaluation of stress distribution in critical anatomic regions following the Le Fort I osteotomy by three-dimensional finite element analysis.

In this study, we aimed to measure the stresses both on the pterygoid plates and the cranial base during the down-fracture and at the time of pterygomaxillary osteotomy by using the finite element analysis method to have an idea about the possible causes of complications. Three different surgical approaches were applied to the obtained models. In the Model 1, Le Fort I cuts without pterygomaxillary separation was applied. In the Model 2, same standard Le Fort I cuts were applied with pterygomaxillary separation. Then both models were subjected to a force of 150 N over the anterior spina nasalis to simulate down-fracture. In the third model, same standard Le Fort I cuts were applied. Following this procedure, a force of 50 N was applied with a sharp osteotome to the pterygomaxillary junction to simulate osteotomy. According to the results of this experimental study, the cranial base stress values decreased during the down-fracture in the Model 2. Moreover, it was found that the force transmitted to the base of the skull is less when the height of the pterygomaxillary osteotome is limited to 1 cm as we applied in Model 3.

The effects of amoxicillin with or without clavulanic acid on the postoperative complaints after third molar surgery: a retrospective chart analysis.

PURPOSE: The aim of this chart-based retrospective study was to evaluate the effects of orally administered amoxicillin alone or amoxicillin combined with clavulanic acid on the frequency of post-operative complications and patients' comfort after mandibular third molar surgery. MATERIALS AND METHODS: The records of patients who had undergone lower third molar surgery between October 2014 and December 2015 were examined. A total of 62 patients who had fully impacted teeth in mesioangular position and who had been prescribed same type and dose of anti-inflammatory drug were included in this study. Among them, 32 subjects were found to have been prescribed 500 mg amoxicillin trihydrate orally every 8 h for 5 days (Group A) and 30 patients 500 mg amoxicillin trihydrate plus 125 mg potassium clavulanate orally every 8 h for 5 days postoperatively (Group AC). Post-operative pain levels, swelling, presence of trismus, frequency of alveolar osteitis and quality of life (QoL) scores were gathered from patients' charts and were statistically compared. RESULTS: Analysis of the variables showed that there were no significant differences between the Groups A and AC regarding pain levels, swelling, trismus and QoL scores. The frequency of alveolar osteitis was found to be 1.6% in the Group A, however, no significant difference was observed among study groups. CONCLUSION: Within the limitations of this retrospective chart review, it can be stated that amoxicillin and amoxicillin with clavulanic acid might provide similar outcome in terms of patient comfort following third molar surgery.

Histological evaluation of effectiveness of platelet-rich fibrin on healing of sinus membrane perforations: A preclinical animal study.

The aim of this study was to evaluate the effectiveness of platelet-rich fibrin (PRF) in repairing of Schneiderian membrane perforations in rabbit maxillary sinus. A total of 42 female New Zealand rabbits were randomly divided into two groups. Symmetrical bony defects were created 1 cm in diameter and the sinus membranes were exposed. The Schneiderian membranes were elevated in both sinuses and each membrane was perforated with a 1 cm incision. No treatment was applied to the right perforations in both groups. Left-sided perforations were closed with collagen membrane in the first group and PRF membrane in the other group. Seven animals randomly selected from each group were sacrificed at weeks 1, 2 and 4 in order to be able to examine the amounts of lymphocytes, fibroblasts, veins, and collagen fibers in the area where the membranes were applied. Histological analyses showed that there were no statistically significant differences between the collagen membrane and the PRF membrane in the healing of sinus perforation area. PRF may be considered as an alternative application to collagen membrane in sinus membrane perforations.

Biomechanical evaluation of different fixation systems after Le Fort I osteotomy in polyurethane models of unilateral clefts.

We compared the stability of three different titanium plate-and-screw fixation systems after Le Fort I osteotomy in polyurethane models of unilateral clefts. Thirty-six models were divided into 3 groups. In the first group, we adapted standard Plates 1mm thick with 2.0mm screws and placed them bilaterally on the zygomatic buttress and the piriform rim. In the second group, we did the same and added Plates 0.6mm thick with 1.6mm screws between the standard 2mm miniplates on both sides. In the last group, we placed Plates 1.4mm thick with 2.0mm screws bilaterally on the maxillary zygomatic buttress and piriform rim. Each group was tested in the inferosuperior (IS) and anteroposterior (AP) directions with a servo-hydraulic testing unit. In the IS direction, displacement values were not significantly different up to 80N, but between 80 and 210N, those in the 2×1.4mm group were better. In the AP direction, displacement values were not significantly different up to 40N, but between 40 and 180N, they were better in the standard with 1.6×0.6mm group and the 2×1.4mm group. When normal biting forces (90 - 260N) in the postoperative period are considered, the greatest resistance to occlusal loads was seen in the 2×1.4mm group. In the others, the biomechanical properties were better in the AP direction.

Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature.

PURPOSE: We report the results of the intralesional steroid injections for the management of central giant cell granuloma (CGCG) of the jaws. METHODS: Seven CGCGs were treated with intralesional injection of corticosteroids. To accomplish this, 3.5 mL of triamcinolone and 3.5 mL of 0.5 % marcaine with 1/200,000 epinephrine (total 7 mL) were mixed. An adequate amount of steroid was injected into different areas of the lesion. This procedure was repeated on a weekly basis for 6 weeks. RESULTS: Clinical and radiological examination showed complete resolution and ossification of the lesions in four patients. Partial recovery was achieved in two patients. One patient did not respond to the treatment and underwent surgical curettage. CONCLUSIONS: We suggest that intralesional steroid injection is safe and effective for the treatment of CGCG, especially in non-aggressive lesions.

The use of autogeneous mandibular bone block grafts for reconstruction of alveolar defects.

OBJECTIVE: Purpose of this retrospective study was to evaluate outcomes autogenous bone block grafts obtained from mandible for different indications. The healing of the donor and recipient sites in the postoperative period, morbidity and the resorption of the graft were investigated. PATIENTS AND METHODS: Twenty-nine patients grafted with mandibular bone block graft were participated in the present study. Grafting was applied in these patients for three indications; reconstruction of alveolar cleft, lateral crest augmentation before dental implantation and sinus floor augmentation. All operations were performed under local anesthesia and in some cases sedation was used as well. RESULTS: Minimal exposure of the block graft occurred in three alveolar cleft patients. Secondary epithelization was achieved in all cleft patients with no symptoms of infection. In one patient infection was seen in donor site 1-week after the operation. The region was curetted and antibiotics administrated again. Two patients showed an infection of recipient site, after 4 weeks the grafts were removed. In all the patients, as the screw head became apparent until 1 thread, amount of the resorption were considered <1.5 mm. CONCLUSION: The usage of mandibular block grafts is a simple and effective treatment modality for reconstruction of different types of alveolar defects and it also reduces cost of treatment.

Immunohistochemical analysis of Ki-67 in dental follicle of asymptomatic impacted third molars.

INTRODUCTION: Dental follicle (DF) is an ectomesenchymal tissue that surrounds the developing tooth germ and contains precursor cells for cementoblasts, periodontal ligaments and osteoblasts. Radiographically, the DFs are seen as semicircular radiolucencies around unerupted teeth. However, if the DFs are larger than 2.5 mm, they are considered to be a pathological change. AIMS AND OBJECTIVES: The purpose of this study is to assess the cell proliferation activity of DF surrounding an asymptomatic impacted third molar teeth using the Ki 67 proliferation marker and to evaluate the variation of cell proliferation depending on the age factor. MATERIALS AND METHODS: Forty-four specimens of DFs associated with impacted mandibular third molars fully covered by mucosa or bone were surgically removed from 44 patients. The patients were divided into 2 age groups. Twenty of forty-four DFs were between 18 and 29 years (Group 1) and 24 were 30 years and above (Group 2). Ki-67 immunostaining was evaluated in epithelial component of the DFs. RESULTS: Ki 67 expression was found to be 60% in Group 1 and 75% in Group 2. Statistically significant differences were found among the two groups in both the basal layer and the supra-basal layer. CONCLUSION: This study shows that DFs have more proliferative potential in older people as compared to the young and squamous metaplasia may be an early sign of developing lesions of odontogenic origin. Therefore, clinicians should be aware that histopathological changes could be found in DFs without clinical and radiographic alterations.

Effect of 2 flap designs on postoperative pain and swelling after impacted third molar surgery.

OBJECTIVE: The aim of this study was to evaluate 2 flap designs (envelope and modified triangular flap) for postoperative pain and swelling after mandibular impacted third molar surgery. STUDY DESIGN: Thirty patients who had symmetric bilateral fully impacted mandibular third molars were selected. Left teeth were approached with an envelope flap, and right teeth were removed using a modified triangular flap. Postoperative pain and swelling were evaluated until the seventh day by using 2 verbal rating scales. RESULTS: Statistical analyses showed that there were no significant differences between the 2 incision techniques regarding postoperative pain and swelling (P > .05). CONCLUSIONS: There is no significant difference between the envelope and modified triangular flap regarding postoperative pain and swelling after impacted third molar surgery.

Clinicoradiological evaluation of dermis-fat grafts after temporomandibular joint discectomy: A retrospective study.

PURPOSE: The aim of this study was to compare the preoperative and 1-year postoperative clinical and radiological findings of the patients after unilateral temporomandibular joint (TMJ) discectomy with inter-positional abdominal dermis-fat graft. MATERIALS AND METHODS: Fourteen patients underwent unilateral discectomy and dermis-fat grafting between 2008 and 2010. Preoperative and 1-year postoperative clinical parameters such as maximum mouth openings (MMO) and lateral movements (LM) of the mandible were recorded. Additionally, preoperative and postoperative magnetic resonance imagingwas obtained to determine the duration of operated TMJs. RESULTS: All of the 14 patients showed the improvement in mandibular mobility and function. There was a significant increase in the MMO and LM during the follow-up period. Pain levels at follow-up were significantly lower than the preoperative levels. Radiologically, the dermis-fat graft was detected within the joint or surrounding the condyle in all 14 operated joints. The graft material that was found within the joint space was mainly grey in four joints. Ten joints showed heterogeneous material composed of fat interspersed with grey tissue. CONCLUSION: Discectomy and dermis-fat grafting appears to be a successful surgical option regarding to the clinical parameters. However, summed degenerative changes depending on surgical operation should be retained.

Evaluation of discectomy and dermis-fat grafting on the contralateral side.

PURPOSE: We investigated the effects of unilateral discectomy with an abdominal dermis-fat graft of the temporomandibular joint (TMJ) on the contralateral side. PATIENTS AND METHODS: A total of 14 patients who underwent unilateral TMJ discectomy and dermis-fat grafting for severe internal derangement in 2009 and 2010 were included. Clinical parameters, such as maximum mouth opening and lateral movements of the mandible, were recorded preoperatively and at 1 year postoperatively. Preoperative and 1-year postoperative magnetic resonance imaging was conducted to determine the duration of the operated and unoperated TMJs. RESULTS AND CONCLUSIONS: All 14 patients showed improvement in the mandibular mobility and function. However, postsurgical disc displacement without reduction was observed on the unoperated TMJ in 1 patient. Another patient complained of crepitus on the operated TMJ. Primary occlusal contact on the operated side of occlusion was observed in 2 other patients. Maximum mouth opening and measured lateral movements had increased in all patients at 1 year after the operation.

Biomechanical evaluation of malleable noncompression miniplates in mandibular angle fractures: an experimental study.

The purpose of this experimental study was to test the reliability of a single malleable titanium miniplate using Champy's method of fixing fractures of the mandibular angle. Eighteen sheep hemimandibles were used to evaluate 2 plating techniques. The groups were tested with either a single non-compression titanium miniplate or a single malleable titanium miniplate. A cantilever bending biomechanical test model was used for the samples. Each group was tested with vertical forces using a servohydraulic testing unit. The displacement values in each group at each 10N stage up to 90N were compared using 2-way analysis of variance (ANOVA). The displacement values for the 2 groups differed significantly (p<0.01). The variance analyses showed that the biomechanical behaviour of a single non-compression miniplate was better than that of a single malleable miniplate. The non-compression miniplate fixed by screws had greater resistance to occlusal loads than the malleable plate fixed by screws, and the malleable plate alone was not sufficient to withstand the early postoperative bite force.

Treatment of localized Langerhans' cell histiocytosis of the mandible with intralesional steroid injection: report of a case.

Localized Langerhans cell histiocytosis (LLCH), formerly known as eosinophilic granuloma, mainly affects the skull, mandible, vertebrae, and ribs in children and the long bones of adults. Symptoms range from none to pain, swelling, and tenderness over the site of the lesion. General malaise and fever occasionally are present. Radiographically, lesions appear as radiolucent areas with well demarcated borders. LLCH may resolve spontaneously after biopsy in a period of months to years. However, if features include continuous pain, decrease of function, pathologic fractures, migration and resorption of teeth, or rapid progression, then active treatment needs to be considered. Treatment approaches include surgery, radiotherapy, chemotherapy, and intralesional injection of corticosteroids. In children with mandibular LLCH, 1 dose of methyprednisolone succinate injection has proven to be adequate. However, injections have not been performed in cases involving pathologic fracture. We report a new case of LLCH of the mandible that caused a pathologic fracture in an adult patient. Repeated intralesional corticosteroid injections resulted in fracture line disappearance within 14 months and lesion healing by the end of the 36-month follow-up.