RESUMEN
PURPOSE: The purpose of this study was to determine whether a single-use negative pressure wound therapy (NPWT) system achieves individualized goals of therapy when used to treat patients with a variety of wound types. DESIGN: Multiple case series. SUBJECTS AND SETTING: The same comprised 25 participants; their mean age was 51.2 years (SD: 18.2; range: 19-79 years); 14 were male (56%) and 11 were female (44%). Seven study participants withdrew from study participation. Wound etiologies vary; 4 had diabetic foot ulcers; 1 had a full-thickness pressure injury; 7 were treated for management of an abscess or cyst; 4 had necrotizing fasciitis, 5 had nonhealing postsurgical wounds, and 4 had wounds of other etiologies. Data were collected at 2 ambulatory wound care clinics located in the Southeastern United States (Augusta and Austell, Georgia). METHODS: A single-outcome measure was selected for each participant by his or her attending physician at a baseline visit. Selected end points were (1) decrease in wound volume, (2) decrease in size of the tunneling area, (3) decrease in size of the undermining, (4) decrease in the amount of slough, (5) increase in granulation tissue formation, (6) decrease in periwound swelling, and (7) wound bed progression toward transition to another treatment modality (such as standard dressing, surgical closure, flap, or graft). Progress toward the individualized goal was monitored until the goal was achieved (study end point) or a maximum of 4 weeks following initiation of treatment. RESULTS: The most common primary treatment goal was to achieve a decrease in wound volume (22 of 25 study participants), and the goal to increase granulation tissue was chosen for the remaining 3 study participants. A majority of participants (18 of 23, 78.3%) reached their individualized treatment outcome. The remaining 5 participants (21.7%) were withdrawn during the study (for reasons not related to the therapy). The median (interquartile range [IQR]) duration of NPWT therapy was 19 days (IQR: 14-21 days). Between baseline and the final assessment, median reductions in wound area and volume were 42.7% (IQR: 25.7-71.5) and 87.5% (IQR: 30.7-94.6). CONCLUSIONS: The single-use NPWT system achieved multiple individualized treatment objectives in a variety of wound types. Individually selected goals of therapy were met by all study participants who completed the study.
Asunto(s)
Pie Diabético , Terapia de Presión Negativa para Heridas , Humanos , Masculino , Femenino , Persona de Mediana Edad , Cicatrización de Heridas , Terapia de Presión Negativa para Heridas/efectos adversos , Pie Diabético/terapia , Pie Diabético/etiología , Resultado del Tratamiento , GeorgiaRESUMEN
Telemedicine has been successfully used in many areas of medicine, including triage and evaluation of the acute burn patient. The utility of telemedicine during the rehabilitative phase of burn care has yet to be evaluated; therefore, we expanded our telemedicine program to link our burn center with a rehabilitation facility. The goal of this project was to demonstrate cost-effective improvements in the transition and quality of care. A retrospective review was performed on all patients enrolled in our telemedicine/rehabilitation program between March 2013 and March 2014. Data collected included total number of encounters, visits, type of visit, physician time, and readmissions. Transportation costs were based on local ambulance rates between the two facilities. The impact of telemedicine was evaluated with respect to the time saved for the physician, burn center, and burn clinic, as well as rehabilitative days saved. A patient satisfaction survey was also administered. A total of 29 patients participated in 73 virtual visits through the telemedicine project. Virtual visits included new consults, preoperative evaluations, and postoperative follow-ups. A total of 146 ambulance transports were averted during the study period, totaling $101,110. Virtual visits saved 6.8 outpatient burn clinic days, or 73 clinic appointments of 30-min duration. The ability to perform more outpatient surgery resulted in 80 inpatient bed days saved at the burn hospital. The rehabilitation hospital saved an average of 2 to 3 patient days secondary to unnecessary travel. Satisfaction surveys demonstrated patient satisfaction with the encounters, primarily related to time saved. The decrease in travel time for the patient from the rehabilitation hospital to outpatient burn clinic improved adherence to the rehabilitation care plan and resulted in increased throughput at the rehabilitation facility. Videoconferencing between a burn center and rehabilitation hospital streamlined patient care and reduced health care costs, while maintaining quality of care and patient satisfaction. This program has improved inpatient burn rehabilitation by maximizing time spent in therapy and avoiding unnecessary patient travel to offsite appointments.
Asunto(s)
Unidades de Quemados , Quemaduras/rehabilitación , Costos de la Atención en Salud , Satisfacción del Paciente/estadística & datos numéricos , Centros de Rehabilitación , Telemedicina/organización & administración , Adulto , Quemaduras/diagnóstico , Continuidad de la Atención al Paciente , Análisis Costo-Beneficio , Femenino , Humanos , Puntaje de Gravedad del Traumatismo , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Telemedicina/economía , Estados Unidos , Servicios Urbanos de Salud/organización & administración , Cicatrización de Heridas/fisiologíaRESUMEN
Long-term follow-up care of survivors after burn injuries can potentially be improved by the application of patient-reported outcome measures (PROMs). PROMs can inform clinical decision-making and foster communication between the patient and provider. There are no previous reports using real-time, burn-specific PROMs in clinical practice to track and benchmark burn recovery over time. This study examines the feasibility of a computerized, burn-specific PROM, the Young Adult Burn Outcome Questionnaire (YABOQ), with real-time benchmarking feedback in a burn outpatient practice. The YABOQ was redesigned for formatting and presentation purposes using images and transcribed to a computerized format. The redesigned questionnaire was administered to young adult burn survivors (ages 19-30 years, 1-24 months from injury) via an ipad platform in the office before outpatient visits. A report including recovery curves benchmarked to a nonburned relatively healthy age-matched population and to patients with similar injuries was produced for the domains of physical function and social function limited by appearance. A copy of the domain reports as well as a complete copy of the patient's responses to all domain questions was provided for use during the clinical visit. Patients and clinicians completed satisfaction surveys at the conclusion of the visit. Free-text responses, included in the satisfaction surveys, were treated as qualitative data adding contextual information about the assessment of feasibility. Eleven patients and their providers completed the study for 12 clinical visits. All patients found the ipad survey and report "easy" or "very easy" to use. In nine instances, patients "agreed" or "strongly agreed" that it helped them communicate their situation to their doctor/nurse practitioner. Patients "agreed" or "strongly agreed" that the report helped them understand their course of recovery in 10 visits. In 11 visits, the patients "agreed" or "strongly agreed" that they would recommend this feedback to others. Qualitative comments included: "it helped organize my thoughts of recovery," "it opened lines of communication with the doctor," "it showed me how far I have come, and how far I need to go," and "it raised questions I would not have thought of." Only four of 12 provider surveys agreed that it helped them understand a patient's condition; however, in two visits, the providers stated that it helped identify a pertinent clinical issue. During two visits, providers stated that a treatment plan was discussed or recommended based on the survey results. Separately, qualitative comments from the providers included "survey was not sensitive enough to identify that this patient needed surgery for their scars." This is the first report describing clinical use of a burn-specific patient reported outcome measure. Real-time feedback using the ipad YABOQ was well received for the most part by the clinicians and burn survivors in the outpatient clinic setting. The information provided by the reports can be tested in a future randomized controlled clinical study evaluating impacts on physician decisions.
Asunto(s)
Benchmarking , Quemaduras/terapia , Sistemas de Computación , Evaluación del Resultado de la Atención al Paciente , Encuestas y Cuestionarios , Adulto , Quemaduras/fisiopatología , Quemaduras/psicología , Estudios de Factibilidad , Femenino , Humanos , Masculino , Satisfacción del Paciente , Proyectos Piloto , Adulto JovenRESUMEN
The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have undergone allogeneic hand transplantation to date worldwide. While outcomes are favorable, risks and side effects of transplantation and long-term immunosuppression pose a significant ethical dilemma. An autologous, bio-artificial graft based on native extracellular matrix and patient derived cells could be produced on demand and would not require immunosuppression after transplantation. To create such a graft, we decellularized rat and primate forearms by detergent perfusion and yielded acellular scaffolds with preserved composite architecture. We then repopulated muscle and vasculature with cells of appropriate phenotypes, and matured the composite tissue in a perfusion bioreactor under electrical stimulation in vitro. After confirmation of composite tissue formation, we transplanted the resulting bio-composite grafts to confirm perfusion in vivo.
Asunto(s)
Miembros Artificiales , Órganos Bioartificiales , Matriz Extracelular/química , Músculo Esquelético/crecimiento & desarrollo , Células Madre/citología , Andamios del Tejido , Animales , Diferenciación Celular/fisiología , Sistema Libre de Células , Células Cultivadas , Análisis de Falla de Equipo , Masculino , Músculo Esquelético/citología , Diseño de Prótesis , Ratas , Ratas Sprague-Dawley , Células Madre/fisiología , Ingeniería de Tejidos/instrumentaciónRESUMEN
This article presents a small case series demonstrating clinical success with thrombolytic agents for severe frostbite injury to the lower extremities. The authors report three patients with severe frostbite injuries to their distal lower extremities who were managed with urgent interventional radiology and intra-arterial tissue plasminogen activator infusion according to a prespecified protocol. Limbs and digits were successfully salvaged and patients returned to normal activity within 2 weeks. Although further studies are needed, results of this study support a new approach in the management of frostbite: from conservative management and observation to urgent interventional radiology and possible tissue plasminogen activator infusion. A protocol for the management of such injuries is presented.
Asunto(s)
Fibrinolíticos/administración & dosificación , Dedos/diagnóstico por imagen , Congelación de Extremidades/tratamiento farmacológico , Activador de Tejido Plasminógeno/administración & dosificación , Dedos del Pie/diagnóstico por imagen , Adulto , Dedos/irrigación sanguínea , Congelación de Extremidades/diagnóstico por imagen , Humanos , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Cintigrafía , Dedos del Pie/irrigación sanguínea , Resultado del TratamientoRESUMEN
Diagnosis and management of infectious endocarditis are particularly challenging in patients with severe burns. Cases requiring operative intervention are likely to have higher complication rates as a result of poor wound healing, recurrent bacteremia secondary to burn wound manipulation, and sequelae of anticoagulation in patients who require repeated reconstructive and cosmetic procedures. Few case reports exist describing mitral valve replacement for infectious endocarditis in burn patients. In this article, we review the literature to describe and address these challenges, and present what we believe to be the first case of mitral valve repair for infectious endocarditis in a thermally injured patient.
Asunto(s)
Antibacterianos/uso terapéutico , Quemaduras/terapia , Farmacorresistencia Bacteriana Múltiple , Endocarditis Bacteriana/terapia , Anuloplastia de la Válvula Mitral/métodos , Válvula Mitral/cirugía , Infecciones por Pseudomonas/terapia , Adulto , Quemaduras/complicaciones , Endocarditis Bacteriana/complicaciones , Humanos , Masculino , Infecciones por Pseudomonas/complicaciones , Toracotomía/métodosRESUMEN
One of the fundamental aspects of initial burn care is the ability to accurately measure the TBSA of injured tissue. Discrepancies between initial estimates of burn size and actual TBSA (determined at the burn unit) have long been reported. These inconsistencies have the potential for unnecessary patient transfer and inappropriate fluid administration which may result in morbidity. In an effort to study these inconsistencies and their impact on initial care, we evaluated the differences between initial TBSA estimates and its impact on fluid resuscitation at an American Burn Association-verified pediatric burn center. A prospective observational study of 50 consecutive burn patients admitted to Shriner's Hospital for Children in Boston, Massachusetts, between October 2011 and April 2012 was performed. Data collected included age, mechanism of burn injury, type of referral center, referring hospital TBSA, and volume of fluid administration as well as admission TBSA and volume of fluid administration. Determination of over or under resuscitation was based on comparing the amount of fluids received at the referral center to that received at the pediatric burn center. A total of 50 patients were admitted during the 7-month study period. The average age was 4.1 years old (25 days-16 years) and the average TBSA was 2.5% (0.25-55%). There were significant differences in the TBSA calculations between referring centers and the pediatric burn center. Overestimation of scald and contact burn size (P < .05) was noted with no difference in flame burn size estimation. Community referrals were more likely than tertiary centers to overestimate TBSA (P < .05 vs P = .29). Overall, 59% of study patients were administered more fluid at the referring hospital than would have been expected by the burn size calculated at our facility. Inconsistencies with the estimation of TBSA burn between referring hospitals and tertiary referral centers remains a problem in pediatric patients and may lead to inappropriate resuscitation. This study highlights the continued need for educational outreach programs and for the provision of novel resources to initial burn providers. Additional support through online resources (eg, Lund-Browder diagram) and remotely assisting providers during their TBSA measurements are potential options which may help to improve the initial care of burn patients.
Asunto(s)
Quemaduras/diagnóstico , Quemaduras/terapia , Fluidoterapia/métodos , Examen Físico/métodos , Resucitación/métodos , Adolescente , Mapeo del Potencial de Superficie Corporal , Unidades de Quemados , Quemaduras/mortalidad , Niño , Preescolar , Diagnóstico Precoz , Femenino , Estudios de Seguimiento , Humanos , Lactante , Puntaje de Gravedad del Traumatismo , Masculino , Pediatría , Estudios Prospectivos , Resucitación/mortalidad , Medición de Riesgo , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
Finely tuned to respond quickly to infections, neutrophils have amazing abilities to migrate fast and efficiently towards sites of infection and inflammation. Although neutrophils ability to migrate is perturbed in patients after major burns, no correlations have yet been demonstrated between altered migration and higher rate of infections and sepsis in these patients when compared to healthy individuals. To probe if such correlations exist, we designed microfluidic devices to quantify the neutrophil migration phenotype with high precision. Inside these devices, moving neutrophils are confined in channels smaller than the neutrophils and forced to make directional decisions at bifurcations and around posts. We employed these devices to quantify neutrophil migration across 18 independent parameters in 74 blood samples from 13 patients with major burns and 3 healthy subjects. Blinded, retrospective analysis of clinical data and neutrophil migration parameters revealed that neutrophils isolated from blood samples collected during sepsis migrate spontaneously inside the microfluidic channels. The spontaneous neutrophil migration is a unique phenotype, typical for patients with major burns during sepsis and often observed one or two days before the diagnosis of sepsis is confirmed. The spontaneous neutrophil migration phenotype is rare in patients with major burns in the absence of sepsis, and is not encountered in healthy individuals. Our findings warrant further studies of neutrophils and their utility for early diagnosing and monitoring sepsis in patients after major burns.
Asunto(s)
Quemaduras/complicaciones , Enfermedades del Sistema Inmune/complicaciones , Trastornos Leucocíticos/complicaciones , Sepsis/complicaciones , Sepsis/inmunología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Técnicas Analíticas Microfluídicas , Persona de Mediana Edad , Fenotipo , Estudios Retrospectivos , Sepsis/diagnóstico , Adulto JovenRESUMEN
As a result of continuous development in the treatment of burns, the LD50 (the burn size lethal to 50% of the population) for thermal injuries has risen from 42% total body surface area (TBSA) during the 1940s and 1950s to more than 90% TBSA for young thermally injured patients. This vast improvement in survival is due to simultaneous developments in critical care, advancements in resuscitation, control of infection through early excision, and pharmacologic support of the hypermetabolic response to burns. This article reviews these recent advances and how they influence modern intensive care of burns.
Asunto(s)
Quemaduras/terapia , Cuidados Críticos/métodos , Lesión Renal Aguda/etiología , Lesión Renal Aguda/terapia , Fluidoterapia/métodos , Humanos , Hiperglucemia/etiología , Hiperglucemia/prevención & control , Enfermedades Metabólicas/etiología , Enfermedades Metabólicas/terapia , Respiración Artificial/métodos , Infección de Heridas/prevención & controlAsunto(s)
Amputación Traumática/cirugía , Traumatismos por Explosión/cirugía , Bombas (Dispositivos Explosivos) , Explosiones , Cuerpos Extraños/diagnóstico por imagen , Migración de Cuerpo Extraño/diagnóstico por imagen , Corazón/diagnóstico por imagen , Traumatismos de la Pierna/diagnóstico por imagen , Adulto , Amputación Quirúrgica/rehabilitación , Amputación Traumática/terapia , Artefactos , Traumatismos por Explosión/diagnóstico , Traumatismos por Explosión/rehabilitación , Traumatismos por Explosión/terapia , Boston , Quemaduras/terapia , Nalgas/diagnóstico por imagen , Ecocardiografía , Electrocardiografía , Traumatismos de los Pies/diagnóstico por imagen , Traumatismos de los Pies/cirugía , Cuerpos Extraños/cirugía , Humanos , Pierna/diagnóstico por imagen , Traumatismos de la Pierna/cirugía , Masculino , Tomografía Computarizada Multidetector , Radiografía Torácica , Carrera , TorniquetesRESUMEN
OBJECTIVE: To determine and compare outcomes with accepted benchmarks in burn care at 6 academic burn centers. BACKGROUND: Since the 1960s, US morbidity and mortality rates have declined tremendously for burn patients, likely related to improvements in surgical and critical care treatment. We describe the baseline patient characteristics and well-defined outcomes for major burn injuries. METHODS: We followed 300 adults and 241 children from 2003 to 2009 through hospitalization, using standard operating procedures developed at study onset. We created an extensive database on patient and injury characteristics, anatomic and physiological derangement, clinical treatment, and outcomes. These data were compared with existing benchmarks in burn care. RESULTS: Study patients were critically injured, as demonstrated by mean % total body surface area (TBSA) (41.2 ± 18.3 for adults and 57.8 ± 18.2 for children) and presence of inhalation injury in 38% of the adults and 54.8% of the children. Mortality in adults was 14.1% for those younger than 55 years and 38.5% for those aged 55 years and older. Mortality in patients younger than 17 years was 7.9%. Overall, the multiple organ failure rate was 27%. When controlling for age and % TBSA, presence of inhalation injury continues to be significant. CONCLUSIONS: This study provides the current benchmark for major burn patients. Mortality rates, notwithstanding significant % TBSA and presence of inhalation injury, have significantly declined compared with previous benchmarks. Modern day surgical and medically intensive management has markedly improved to the point where we can expect patients younger than 55 years with severe burn injuries and inhalation injury to survive these devastating conditions.
Asunto(s)
Benchmarking , Quemaduras/terapia , Cuidados Críticos/métodos , Insuficiencia Multiorgánica/epidemiología , Adolescente , Adulto , Distribución por Edad , Quemaduras/diagnóstico , Quemaduras/mortalidad , Enfermedad Crítica , Femenino , Estudios de Seguimiento , Mortalidad Hospitalaria/tendencias , Humanos , Incidencia , Tiempo de Internación/tendencias , Masculino , Persona de Mediana Edad , Insuficiencia Multiorgánica/etiología , Estudios Prospectivos , Estudios Retrospectivos , Índices de Gravedad del Trauma , Estados Unidos/epidemiología , Adulto JovenRESUMEN
Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double-edged sword. Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil-induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats with burn injuries correlates with improved survival in a classical double-injury model of sequential burn and septic insults. We uncovered that the directionality of neutrophils from burned rats can be restored both in vitro by 1 nM resolvin D2 (RvD2) and in vivo by RvD2 for 7 d, 25 ng/kg body mass (8-10 ng/rat). Restoring neutrophil directionality dramatically increases survival after a second septic insult at d 9 postburn. Survival of RvD2-treated animals increases from 0 to 100% after lipopolysaccharide injection and is extended by 1 wk after cecal ligation. Survival does not significantly increase when the restoration of neutrophil directionality is incomplete, following shorter regimens of RvD2. We conclude that restoring neutrophil directionality using RvD2 could have prophylactic value and delay lethal complications after burn injuries.
Asunto(s)
Quemaduras/tratamiento farmacológico , Ácidos Docosahexaenoicos/farmacología , Neutrófilos/efectos de los fármacos , Neutrófilos/fisiología , Animales , Quemaduras/complicaciones , Quemaduras/fisiopatología , Quimiotaxis de Leucocito/efectos de los fármacos , Quimiotaxis de Leucocito/fisiología , Ácidos Docosahexaenoicos/fisiología , Masculino , Ratas , Ratas Wistar , Sepsis/complicaciones , Sepsis/tratamiento farmacológico , Sepsis/fisiopatologíaRESUMEN
OBJECTIVE: Although enteral nutrition is the ideal mode of nutritional support following burn injury, it is often interrupted during episodes of severe sepsis and hemodynamic instability, leading to significant energy and protein deficits. Parenteral nutrition is not commonly used in burn centers due to concerns that it will lead to hyperglycemia, infection, and increased mortality. However, parenteral nutrition is often utilized in our burn unit when goal rate enteral nutrition is not feasible.To determine the safety and efficacy of a standardized protein-sparing parenteral nutrition protocol in which glucose infusion is limited to 5-7 mg/kg/hour. DESIGN: Retrospective observational study. SETTING: Pediatric burn hospital. PATIENTS: A retrospective medical record review of all children admitted to our hospital with burns ≥ 30% total body surface area was conducted. Only patients admitted within one week of injury and who survived > 24 hours after admission were included in this study. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of the 105 patients who met the inclusion criteria, 96 (91%) received parenteral nutrition or a combination of parenteral nutrition and enteral nutrition at some point during their care. Nine patients received only enteral nutrition. Demographic data were similar between groups. Protein intake was significantly higher in the parenteral nutrition group. Incidence of catheter-related blood infections did not differ between groups. Use of parenteral nutrition was not associated with blood or respiratory infections. Overall mortality rate was low (4%), as most patients (96%) achieved wound closure and were discharged home. CONCLUSIONS: Judicious use of parenteral nutrition is a safe and effective means of nutritional support when goal enteral nutrition cannot be achieved. A hypocaloric, high-nitrogen parenteral nutrition solution can reduce energy and protein deficits while minimizing complications commonly associated with parenteral nutrition usage.
Asunto(s)
Quemaduras/terapia , Nutrición Parenteral , Adolescente , Quemaduras/complicaciones , Quemaduras/mortalidad , Infecciones Relacionadas con Catéteres/epidemiología , Infecciones Relacionadas con Catéteres/etiología , Niño , Preescolar , Humanos , Hiperglucemia/epidemiología , Hiperglucemia/etiología , Hiperglucemia/prevención & control , Lactante , Modelos Logísticos , Nutrición Parenteral/efectos adversos , Nutrición Parenteral/métodos , Soluciones para Nutrición Parenteral , Neumonía/epidemiología , Neumonía/etiología , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
The choice of appropriate empiric antimicrobial therapy for burn patients with suspected multidrug-resistant organisms remains a challenge. Burn patients transferred from outside the United States seem to be at particularly high risk. Given this perceived risk of multidrug resistance among our international patient population, we set out to determine which empiric antimicrobial therapy should be used at admission. A retrospective analysis was conducted of all burn patients admitted to a pediatric burn specialty hospital between 2006 and 2010. Patients with burns >10% TBSA were included. Demographics, burn data, and routine/nonroutine culture data were collected. Of the 385 total patients, 133 (34.5%) were international. International patients had significantly larger burns (39.73 vs 22.80% TBSA; P < .001) and more inhalational injuries (27.1 vs 16.3%; P < .03) than their U.S. counterparts. International patients presented with a higher incidence of infection in general (66.9 vs 2%; P < .001) as well as a higher prevalence of infection caused by multidrug-resistant bacteria (51.2 vs 1%; P < .001) and pan-multidrug-resistant bacteria (13.5 vs 1.1%; P < .001). Bacterial resistance was not related to the length of time after burn injury or to a delay in transfer. In conclusion, multidrug-resistant and pan-resistant organisms seem to be more prevalent among the international pediatric burn population when compared with the U.S. pediatric burn population. Given the relatively high incidence of pan-resistant gram-negative organisms among international transfers, colistin seems to be a reasonable choice for empiric antimicrobial coverage for presumed infections.
Asunto(s)
Quemaduras/microbiología , Infecciones por Bacterias Gramnegativas/tratamiento farmacológico , Infecciones por Bacterias Gramnegativas/microbiología , Infección de Heridas/tratamiento farmacológico , Infección de Heridas/microbiología , Niño , Preescolar , Farmacorresistencia Bacteriana Múltiple , Femenino , Hospitales Pediátricos , Humanos , Incidencia , Internacionalidad , Tiempo de Internación/estadística & datos numéricos , Modelos Lineales , Masculino , Massachusetts/epidemiología , Prevalencia , Estudios Retrospectivos , Resultado del Tratamiento , Infección de Heridas/epidemiologíaRESUMEN
Burn injuries are known to occur from magnetic resonance imaging. Prevention efforts focus on avoiding internal and external metallic objects from contacting the patient's tissue during image acquisition. Despite rigorous screening, however, there is a subset of thermal injuries that can occur through the formation of closed loops of current within the patient. This case report describes an example of this uncommon type of injury as well as a successful, nonoperative management approach. Given the frequent use of magnetic resonance imaging, we report this rare case to raise awareness of this mechanism of injury and its treatment.
Asunto(s)
Traumatismos del Brazo/etiología , Traumatismos del Brazo/terapia , Quemaduras/etiología , Quemaduras/terapia , Traumatismos de los Dedos/etiología , Traumatismos de los Dedos/terapia , Imagen por Resonancia Magnética/efectos adversos , Adolescente , Humanos , MasculinoRESUMEN
Burn-specific guidelines for optimal catheter rotation, catheter type, insertion methods, and catheter site care do not exist, and practices vary widely from one burn unit to another. The purpose of this study was to define current practices and identify areas of practice variation for future clinical investigation. An online survey was sent to the directors of 123 U.S. burn centers. The survey consisted of 23 questions related to specific practices in placement and maintenance of central venous catheters (CVCs), arterial catheters, and peripherally inserted central catheters (PICCs). The overall response rate was 36%; response rate from verified centers was 52%. Geographic representation was wide. CVC and arterial catheter replacement varied from every 3 days (24% of sites) to only for overt infection (24% of sites); 23% of sites did not use the femoral position for CVC placement. Nearly 60% of units used some kind of antiseptic catheter. Physicians inserted the majority of catheters, and 22% of sites used nonphysicians for at least some insertions. Ultrasound was routinely used by less than 50% of units. A wide variety of post-insertion dressing protocols were followed. PICCs were used in some critically injured patients in 37% of units; the majority of these users did not rotate PICCs. Thus, it can be surmised that wide practice variation exists among burn centers with regard to insertion and maintenance of invasive catheters. Areas with particular variability that would be appropriate targets of clinical investigation are line rotation protocols, catheter site care protocols, and use of PICCs in acute burns.
Asunto(s)
Unidades de Quemados , Cateterismo/estadística & datos numéricos , Pautas de la Práctica en Medicina/estadística & datos numéricos , Cateterismo/normas , Humanos , Encuestas y Cuestionarios , Estados UnidosRESUMEN
It has been demonstrated that restoration of function to compromised tissue can be accomplished by transplantation of bone marrow stem cells and/or embryonic stem cells (ESCs). One limitation to this approach has been the lack of noninvasive techniques to longitudinally monitor stem cell attachment and proliferation. Recently, murine ESC lines that express green fluorescent protein (GFP), luciferase (LV), and herpes simplex thymidine kinase (HVTK) were developed for detection of actively growing cells in vivo by imaging. In this study, the authors investigated the use of these ESC lines in a burned mouse model using Integra® as a delivery scaffolding/matrix. Two different cell lines were used: one expressing GFP and LV and the other expressing GFP, LV, and HVTK. Burn wounds were produced by application of a brass block (2 × 2 cm kept in boiling water before application) to the dorsal surface of SV129 mice for 10 seconds. Twenty-four hours after injury, Integra® with adherent stem cells was engrafted onto a burn wound immediately after excision of eschar. The stem cells were monitored in vivo by measuring bioluminescence with a charge-coupled device camera and immunocytochemistry of excised tissue. Bioluminescence progressively increased in intensity over the time course of the study, and GFP-positive cells growing into the Integra® were detected. These studies demonstrate the feasibility of using Integra® as a scaffolding, or matrix, for the delivery of stem cells to burn wounds as well as the utility of bioluminescence for monitoring in vivo cellular tracking of stably transfected ESC cells.