One Step before Synthesis: Structure-Property-Condition Relationship Models to Sustainable Design of Efficient TiO2-Based Multicomponent Nanomaterials.

To control the photocatalytic activity, it is essential to consider several parameters affecting the structure of ordered multicomponent TiO2-based photocatalytic nanotubes. The lack of systematic knowledge about the relationship between structure, property, and preparation parameters may be provided by applying a machine learning (ML) methodology and predictive models based on the quantitative structure-property-condition relationship (QSPCR). In the present study, for the first time, the quantitative mapping of preparation parameters, morphology, and photocatalytic activity of 136 TiO2 NTs doped with metal and non-metal nanoparticles synthesized with the one-step anodization method has been investigated via linear and nonlinear ML methods. Moreover, the developed QSPCR model, for the first time, provides systematic knowledge supporting the design of effective TiO2-based nanotubes by proper structure manipulation. The proposed computer-aided methodology reduces cost and speeds up the process (optimize) of efficient photocatalysts' design at the earliest possible stage (before synthesis) in line with the sustainability-by-design strategy.

[Effects of electrostimulation therapy in selected cases of vocal fold paralysis]. / Efekty terapii elektrostymulacyjnej w wybranych przypadkach porazen faldów glosowych.

Paralytic dysphonia is the most serious neurogenic pathology of voice quality. An important issue is to identify methods which support routine treatment. AIM: The aim of the study is to assess voice quality after electrostimulation (ES) therapy in patients with paralytic dysphonia. MATERIALS AND METHODS: The group consisted of 40 patients diagnosed at the Department of Clinical Phonoaudiology and Logopedics and then treated at the Phoniatric Outpatient Clinic of the Medical University of Bialystok, Poland in years 2013-2015. In the assessment of voice quality GRBAS scale was used, it was determined voice attack, maximum phonation time (MPT), voice self-evaluation of patients were analyzed using a questionnaire Voice Handicap Index (VHI). Visualization of the vocal fold vibration was performed using High Speed Digital Imaging (HSDI) technique. The acoustic examination of voice was made during phonation of vowel "a" and continuous linguistic text. Electrostimulation (ES) therapy was performed after determining the ratio á, which conditioned the choice of set of voice exercises (VE) and duration of one-time electrical impulse stimulation. Subjective and objective evaluation was performed before and after ES therapy. The results were compared with a group of patients that received the routine therapy without ES. RESULTS: Subjective, objective and self-evaluation analysis of voice showed a improvement of its quality after ES. Increasing the mobility of vocal folds after ES resulted in an improvement of voice quality parameters in the acoustic assessment. Effectiveness of the ES therapy on the function of the vocal fold vibration was confirmed by HSDI technique. CONCLUSIONS: Studies have shown that ES therapy is a valuable addition to the routine method of treatment of paralytic dysphonia.

[High-speed digital imaging in the diagnosis of voice pathologies]. / Technika szybkiego filmu w sekwencji cyfrowej w diagnostyce patologii narzadu glosu.

Technique of high-speed digital imaging (HSDI) is unique technique, allowing for assessment of real vocal fold vibrations. AIM: The aim of the study is to present the usefulness of HSDI in the diagnosis of clinical type of dysphonia. MATERIALS AND METHODS: The study group was diagnosed at the Department of Clinical Phonoaudiology and Logopedics at the Medical University of Bialystok and treated at the Phoniatric Clinic in years 2012-2015. HSDI technique with a digital camera was used for visualization of the larynx. The rigid endoscope with 90° optics was used for visualizing the vocal folds vibrations during phonation of "e" vowel, at the rate of 4000 frames per second. Playback of recorded sequence set at 15 frames per second, what allowed to assess vocal folds vibrations in slow motion mode during over 8 minutes. Mucosal wave (MW), glottal closure, symmetry, regularity and synchrony of vocal fold vibration were analyzed. Digital kymography (DKG) of the larynx was made for analyzing the value of the Open Quotient (OQ) in the assessment of degree of glottal insufficiency. RESULTS: In the analyzed group of patients, the functional dysphonia was diagnosed in 71%, organic dysphonia in 29% patients. In 68%, glottal insufficiency was registered in the rear part at the glottis. The oedematous-hypertrophic changes were diagnosed in 21% of the cases, hypertrophic changes of larynx - in 6%, vocal fold polyps - in 3% and vocal fold nodules - in 2% of patients. CONCLUSIONS: Examination of the larynx by using HSDI technique is quick, non-invasive to patient. HSDI allows to objective assessment of the degree of severity of insufficiency of glottal closure, what is confirmed by the objective values of the OQ. Evaluation of MW allows for the differentiation of clinical type and severity of organic dysphonia.

[Rehabilitation of phonosurgically treated patients with edematous-hypertrophic changes of larynx]. / Rehabilitacja pacjentów leczonych fonochirurgicznie z powodu zmian obrzekowo-przerostowych krtani.

UNLABELLED: Advanced change of organic dysphonia are an indication for phonosurgery. Edematous-hypertrophic changes are cause of serious disturbances of voice. High-speed digital imaging (HSDI) technique is the unique method, allowing for assessment the effects of therapy and rehabilitation. AIM: The aim of the study is evaluation the usefulness of vibratory method in voice rehabilitation of patients with edematous-hypertrophic changes treated phonosurgically. MATERIALS AND METHODS: The group I contained 40 patients with edematous-hypertrophical changes phonosurgically treated. Type of clinical dysphonia was diagnosed with HSDI technique. Glottal closure was evaluated according to Committee on Phoniatrics of the European Laryngological Society (ELS) classification, postoperative material was pathomorphologically verified by Transmission Electron Microscopy (TEM). Patients with hyperfunction of larynx were rehabilitated for 21 days using massage device and after that visualization of larynx by HSDI technique was made again. Control group contains people with physiological voice. RESULTS: Severe dysphonia with oedematous-hypertrophic changes was found by HSDI technique in group I. Postoperative material was evaluated histopathological by TEM and confirmed the existing clinical morphological changes of larynx. Hyperfunction of phonation organ were diagnosed in 30 patients (75%). After 21 days of rehabilitation using massage device, hyperfunction was reduced as confirmed by HSDI. Normalization of amplitude, regularity, synchrony of vibration and physiological glottal closure were found at 67% cases. CONCLUSIONS: HSDI technique in digital sequence is useful in the diagnosis of edematous-hypertrophic changes of the larynx and monitoring the effects of the rehabilitation. Pathomorphological evaluation of postoperative material made by TEM confirmed the rightness of clinical diagnosis of the edematous-hypertrophic changes by HSDI. The consequence of phonosurgical procedures in edematous-hypertrophic changes of larynx is hyperfunction of larynx, confirmed objectively by HSDI technique. The use of massage device causes relaxation of laryngeal structures, normalizing parameters of visualizing evaluation.

[The usage of modern physioterapeutic methods of rehabilitation in treatment of chosen kinds of dysphonia]. / Zastosowanie nowoczesnych fizjoterapeutycznych metod rehabilitacji w leczeniu wybranych postaci dysfonii.

UNLABELLED: Voice quality disorders--dysphonias are the significant problem from therapeutic, social and economic point of view. The routine therapy does not always bring spectacular effects. The important role play the innovative methods supporting therapy of voice quality disorders. PURPOSE: The aim of the study is to assess the effects of vibratory therapy of the larynx (Medical VR) in patients with hyperfunctional dysphonia and stimulating currents in phonatory exercises (VocaStim-Master) in paralytic dysphonia based on the analysis of parameters of objective assessment of voice quality. MATERIAL AND METHODS: Forty patients with hyperfunctional dysphonia treated routinely were included in the study. 20 patients apart from the routine therapy were additionally treated using the vibratory therapy of regions of the larynx (Medical VR, CyberBioMed LLC). In group of 40 patients with paralytic dysphonia, in 20 patients the adjuvant therapy by stimulating currents in phonatory exercises (VocaStim-Master, Physiomed) was used. The results of treatment and adjuvant therapy in hyperfunctional and paralytic dysphonia were analyzed based on: MPT, parameters of stroboscopic and acoustic evaluation (F(0), Jitter, Shimmer, NHR) and narrow-band spectrography. RESULTS AND CONCLUSIONS: : The analysis of the results indicated the usefulness of used parameters of objective assessment of voice quality taking into consideration the diagnostic and therapeutic aspect in hyperfunctional and paralytic dysphonia. Adjuvant vibratory therapy of the larynx in hyperfunctional dysphonia and stimulating currents in phonatory exercises in paralytic dysphonia improved the effectiveness of the therapy, what was confirmed by the analysis of parameters of objective assessment of voice quality.

[The impact of vibratory stimulation therapy on voice quality in hyperfunctional occupational dysphonia]. / Wplyw wibracyjnej terapii stymulujacej na jakosc glosu w postaci hiperfunkcjonalnej dysfonii zawodowej.

UNLABELLED: Hyperfunctional dysphonia is the most frequent type of occupational functional dysphonia. Pharmacotherapy, physiotherapy and psychotherapy are used in the treatment of occupational dysphonia. Vibratory massages of the regions of the larynx relax the external muscles of neck, which have an indirect impact on the tension of the vocal folds. PURPOSE: The aim of the study is to assess the impact of vibratory stimulation therapy on voice quality in patients with hyperfunctional occupational dysphonia treated pharmacologically. MATERIAL AND METHODS: Forty patients with hyperfunctional occupational dysphonia treated phoniatrically in the Phoniatric Outpatient Clinic were included in the study. Patients were divided into two groups. Group I consisted of 20 patients treated pharmacologically. In group II, including 20 patients, apart from pharmacotherapy the vibratory stimulation therapy by the device of VR type (CyberBioMed LLC) was used. In the analysis of voice quality the evaluation of the vocal folds vibration using videolaryngostroboscopy and acoustic assessment of voice were conducted. RESULTS AND CONCLUSIONS: The perceptual assessment of voice, the visualization of the vocal folds vibration in stroboscopic examination of the larynx and the acoustic assessment of voice enable the appropriate diagnostics of the clinical type and voice quality in hyperfunctional dysphonia. The tension of superficial and deep muscles of neck has the impact on the phonatory function of the larynx. Pharmacological treatment improves the voice quality in hyperfunctional occupational dysphonia. Pharmacological treatment combines with the relaxation of muscles of neck using the device of VR type significantly improve voice quality in hyperfunctional occupational dysphonia.

Morphological aspects of the euphonic voice.

The high quality of a euphonic voice is the result of complex interactions between many organs and systems. Vibrating vocal folds play a crucial role in this process. Their physiological motion is conditioned by the presence of the layered structure of laryngeal mucosa. In this study, we assessed the degree of dysphonia according to the Union of European Phoniatrics (UEP) scale. Videoendoscopy (VLS) and videostroboscopic (VLSS) examination of the larynx was used to visualize the vibration of the vocal folds. Morphological assessment of the inter-membranous part of the vocal fold mucosa was carried out using material collected after surgical treatment (60%) or obtained from autopsy (40%). The samples were examined by light microscopy and transmission electron microscopy. In euphonic voices, 1° of dysphonia (UEP) and the physiological endoscopic (VLS) and stroboscopic (VLSS) findings of vocal folds were registered. No morphological or ultramorphological changes were observed in the cells of the multilayered flat epithelium, basal membrane or in the stroma. Unchanged epithelial cells were situated on the basal membrane with folds. Moreover, numerous pericytes, vessels with multiplication of basal membranes, scanty collagenous fibers, plasmatic cells and lymphocytes were seen. Morphological changes with signs of atrophy and polypoid degeneration of the vocal fold mucosa were found in only 3 (15%) patients.

Videostroboscopic and morphological aspects of voice disturbances in patients with larynx atrophy and coexisting hypopharynx cancer.

Vocal folds play a crucial role in voice production. The physiological vibrations of vocal folds depend on the unchanged multilayered structure of the vocal folds mucosa. Morphological changes of mucosa are the cause of voice quality disorders - dysphonia. The aim of this study was to determine the morphological base of dysphonia in patients with vocal folds atrophy. A group of 24 patients with larynx atrophy confirmed by endoscopic (VLS) and stroboscopic (VLSS) examination of the larynx was included in the study. The morphological assessment of the larynx mucosa was carried out with the use of the transmission electron microscopy (TEM). Ultramorphological examinations revealed changes in the epithelium, basal membrane and lamina propria of the vocal folds mucosa. An increased number of collagenous fibers, fibroblasts with signs of vacuolar degeneration inflammatory cells and a decreased number of blood vessels and pericytes were observed. Morphological changes found in the epithelium, basal membrane and lamina propria of the vocal folds mucosa were the cause of disorders of vocal folds vibrations registered in the stroboscopic examination of the larynx (VLSS).

[Morphological conditions of dysphonia in patients with vocal folds edema]. / Morfologiczne uwarunkowania dysfonii u chorych z obrzekiem faldów glosowych.

UNLABELLED: Disorders of voice quality are mostly influenced by organic changes in larynx. In the assessment of ultrastructure of vocal fold mucosa the most useful is the technique of transmission electron microscopy (TEM). The organic dysphonia is diagnosed by the perceptual, endoscopic (VLS) and stroboscopic (VLSS) assessment of larynx and acoustic assessment. The aim of the study was to determine morphological changes and voice quality disorders in patients with edema of larynx. MATERIAL AND METHODS: 40 patients with vocal folds edema (I group) and 10 patients with no pathological changes of larynx (II group) were included in the study. The morphological assessment of vocal folds mucosa was carried out with the usage of transmission electron microscopy (TEM). The voice quality was examined by the subjective and objective methods. The endoscopic and stroboscopic (VLS and VLSS) examination of larynx and acoustic analysis of voice were carried out. RESULTS: Morphological changes of vocal folds mucosa were observed. Epithelial cells showed features of vacuolar degeneration. Moreover enlargement of intercellular spaces, small rugosity of basal membrane and inflammatory infiltration of stroma, a large number of blood vessels and a cumulation of elastic and collagenous fibers were observed. CONCLUSIONS: Stillness of vocal folds influenced disorders of voice quality with features of dysphonia. The endoscopic and stroboscopic examination of larynx clinically shows the morphological changes of vocal folds mucosa. Simple and non-invasive acoustic examination of voice in patients with edema of larynx objectively confirms the subjectively registered dysphonia.

[Assessment of speech and linguistic disorders in patients with cochlear implant--preliminary results]. / Ocena mowy i zaburzen jezykowych u chorych z implantem slimakowym--doniesienie wstepne.

UNLABELLED: Cochlear Implant (CI) is the most advanced technical solution in the treatment of profound hearing loss and deafness in patients of all age groups. The aim of the study was to analyse the speech and linguistic disorders in adults with pre- and postlingual deafness rehabilitated with Cochlear implant (CI). MATERIAL AND METHODS: 21 adults with pre- (I group) and postlingual (II group) deafness deriving no benefit from hearing aids participated in this study. Phonatory organ was examined by endoscopy (VLS) and stroboscopy (VLSS). Test of Auditory Perception (TSS) was conducted directly after the activation of speech processor and after rehabilitation. The logopedic assessment before and after CI was based on the examination of motoric activity of articulatory organs, type of respiration, loudness of speech and the assessment of articulation. The linguistic assessment of grammatical and lexical aspect was carried out. The prosodic elements of speech were also analysed. RESULTS: Stroboscopic examination pointed to hypofunction of larynx in patients with prelingual deafness and hyperfunction--in postlingual deafness. The values of TSS were improved after CI, especially in patients with postlingual deafness. The most severe disorders of the efficiency of articulatory organs were observed in patients with prelingual deafness before CI. In the group of prelingually deaf patients disorders of the articulation of vowels and consonants as well as the lexical and grammatical aspect of speech were improved after CI. The correctness of syntax and inflection, development of active vocabulary, improvement of prosodic elements of speech were noticed in patients with postlingual deafness after CI. CONCLUSIONS. Patients with postlingual deafness achieved better results of rehabilitation in auditory perception than prelingually deaf patients. The linguistic improvement of grammatical and lexical aspect was noticed especially in prelingually deaf patients after implantation. This group of patients achieved also the significant progress in prosodic elements of speech in comparison with the results before implantation.

[Analysis of comparison between different kinds of alaryngeal speech in laryngectomized patients with euphonic speech]. / Porównanie rodzajów mowy alaryngealnej chorych po usunieciu krtani z mowa eufoniczna.

UNLABELLED: The aim of the rehabilitation in laryngectomized patients is to produce phonatory communication. It is important to choose the optimal method of rehabilitation. Most of the patients use the oesophageal or pharyngeal speech as an effect of natural rehabilitation with vocalistic method. Another group of larygectomized patients is rehabilitated with surgical method which leads to shunt speech. THE AIM OF STUDY was to compare the quality of oesophageal and shunt speech with euphonic voice to choose the optimal method of rehabilitation in laryngectomized patients. MATERIAL AND METHODS: The quality of vicarious phonation was examined in 30 patients with shunt speech and in 20 patients with oesophageal speech. Examination results of the subjective, objective and acoustic assessment were compared with values registered in physiological (euphonic) speech. The results of objective assessment were statistically analysed. RESULTS: The shunt and oesophageal speech enabled effective verbal communication of laryngectomized patients. The parameters of clinical subjective and objective assessment of shunt speech pointed to its high quality which is similar to physiological phonation. CONCLUSIONS: The acoustic analysis of voice confirmed the results of subjective and objective assessment of quality of shunt voice and speech in laryngectomized patients. In conclusion, the surgical rehabilitation of voice after total laryngectomy gave patients the great opportunity for a remarkable improvement in vicarious phonation.