RESUMEN
The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis (PTB) among coal workers' pneumoconiosis (CWP) patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.
Asunto(s)
Antracosis/complicaciones , Industria del Carbón/normas , Enfermedades Profesionales/complicaciones , Exposición Profesional/análisis , Tuberculosis Pulmonar/etiología , Lugar de Trabajo/normas , Antracosis/diagnóstico , Antracosis/epidemiología , Estudios de Casos y Controles , China , Polvo/análisis , Humanos , Modelos Logísticos , Masculino , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/epidemiología , Factores de Riesgo , Encuestas y Cuestionarios , Tuberculosis Pulmonar/diagnóstico , Tuberculosis Pulmonar/epidemiologíaRESUMEN
OBJECTIVE: To study the effects of aluminum citrate (AC), rare earth compounds (REC) and sodium selenite (SS) on the surface elements of chrysotile fibers and the inhibitory mechanisms of three compounds for chrysotile-induced biological activities. METHODS: After being soaked in 250, 500 and 1000 microg/ml aluminum citrate solutions, 125, 250, 500 and 1000 microg/ml mixed rare earths solutions or 125, 250, 500 and 1000 microg/ml sodium selenite solutions for 10 min or 1 hour, the fabrication and the levels of surface elements of chrysotile fibers were determined. RESULTS: Aluminum citrate, mixed rare earths or sodium selenite all could be adsorbed by chrysotile fibers. After pretreatment of chrysotile fibers with aluminum citrate, mixed rare earths or sodium selenite solutions for 10 min or 1 hour, the corresponding elements or ion on the surface of chrysotile fibers increased with the increase of concentration of the solutions. CONCLUSION: Pretreatment of chrysotile with aluminum citrate, mixed rare earths or sodium selenite solutions can change the fabrication and the levels of surface elements of chrysotile fibers, and inhibit the biological activities of chrysotile by "sealing" some "active sites" on the surface of chrysotile fibers.
