RESUMEN
OBJECTIVES: To study the levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA724, CA242, pepsinogen (PG) I, PGII, gastrin-17 (G-17), the PGI/PGII ratio (PGR), as well as the expression of p27 and Ki67, in patients suffering from early gastric cancer and intraepithelial neoplasia and to provide new markers for the diagnosis of early gastric cancer and precancerous lesions. METHODS: A retrospective study where the blood serum concentration of CEA, CA199, CA724, CA242, PGI, PGII, G-17 and PGR were tested and also the protein expression of p27 and Ki67 was detected in patients tissues by immunohistochemistry in the Gastrointestinal Endoscopy Center of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, from March 2018 to March 2021. RESULTS: Carbohydrate antigen 242 and CA199 levels in tumor tissue significantly differed among the groups. Pepsinogen I levels decreased with increasing disease severity, G-17 levels increased with the aggravation of severity, and p27 expression decreased with the severity. CONCLUSION: The combination of serum gastric function markers (PGI and G-17) and p27 digestive tumor indices can serve as markers for the diagnosis of early gastric cancer and intraepithelial neoplasia.
Asunto(s)
Lesiones Precancerosas , Neoplasias Gástricas , Humanos , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/patología , Antígeno Carcinoembrionario , Estudios Retrospectivos , Antígeno Ki-67 , Biomarcadores de Tumor , Pepsinógeno A , Lesiones Precancerosas/diagnóstico , Lesiones Precancerosas/patología , CarbohidratosRESUMEN
Abstract: Pellagra is a nutritional disease caused by a deficiency of niacin. It may lead to death if not identified and treated timely. We review the literature and report a female patient presented with clinical features of pellagra as a complication of Crohn's disease.
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Pelagra/etiología , Enfermedad de Crohn/complicaciones , Pelagra/patología , Pelagra/tratamiento farmacológico , Piel/patología , Biopsia , Enfermedad de Crohn/tratamiento farmacológico , Resultado del Tratamiento , Queratosis/etiología , Queratosis/patología , Queratosis/tratamiento farmacológicoRESUMEN
Bilobalide (BI) has been widely known as a unique constituent extracted from Ginkgo biloba. The aim of the current study was to reveal the potential efficacy as well as the underlying mechanism of the action of BI on ethanol-induced lesion in gastric mucosa in vivo/vitro. Ethanol (0.2ml/kg) was applied to induce gastric ulcer mice model. Our results indicated that treatment with BI markedly decreased the levels of interleukin-6 (IL-6), IL-1ß and tumor necrosis factor-α (TNF-α) in vivo. Additionally, BI intervation exhibited elevated myeloperoxidase (MPO) level in stomach, increased superoxide dismutase (SOD) activity and decreased malonaldehyde (MDA) content in serum and stomach when compared with those of the model group. It could be also observed that inhibited MAPK/NF-κB pathway expressions occurred after BI treatment both in vivo and in vitro. Taken together, BI exerted a gastro-protective effect against gastric ulceration, which was presumed to be associated with MAPK/NF-κB pathway.
Asunto(s)
Ciclopentanos/farmacología , Células Epiteliales/efectos de los fármacos , Etanol/toxicidad , Furanos/farmacología , Ginkgólidos/farmacología , Úlcera Gástrica/inducido químicamente , Animales , Línea Celular , Supervivencia Celular/efectos de los fármacos , Ciclopentanos/administración & dosificación , Femenino , Furanos/administración & dosificación , Ginkgólidos/administración & dosificación , Humanos , Malondialdehído/metabolismo , Ratones , Ratones Endogámicos BALB C , Organismos Libres de Patógenos Específicos , Estómago/citología , Estómago/patología , Úlcera Gástrica/prevención & control , Superóxido Dismutasa/metabolismoRESUMEN
Pellagra is a nutritional disease caused by a deficiency of niacin. It may lead to death if not identified and treated timely. We review the literature and report a female patient presented with clinical features of pellagra as a complication of Crohn's disease.