Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients.

OBJECTIVES: To investigate the association between schizophrenia and Toxoplasma gondii, and to assess the association of infection with suicide attempts and age of onset of schizophrenia in these patients. METHODS: Case-control study Fars Province, southern Iran. Cases were individuals with psychiatric diagnosis of schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Controls were healthy blood donors, frequency-matched with patients according to age and sex. For the detection of IgG antibodies, enzyme-linked immunosorbent assay (ELISA) was used. Data about demographic information in all subjects and duration of illness and history of suicide attempts in patients with schizophrenia were collected using a brief questionnaire and hospital records. Chi-square test and multivariable logistic regression were used for statistical analyses. RESULTS: Among 99 cases, 42 individuals (42%) were positive for T. gondii antibody, vs. 41 (27%) among 152 controls (OR = 2, 95% CI: 1.2-3.4, P = 0.012). We compared the suicide attempts in patients with schizophrenia based on their T. gondii serologic status. There was a lower rate of suicide attempts in seropositive male patients than seronegative ones (OR = 0.3, 95% CI: 0.1-0.97, P = 0.04). Age of onset of schizophrenia did not differ between T. gondii-infected and non-infected patients. CONCLUSIONS: These findings may have implications for schizophrenia and suicide prevention programmes. However, clearly further studies are required to confirm them.

Psychological consequences of the Bam earthquake on professional and nonprofessional helpers.

This study compared the psychological status of rescue personnel who had formal training (Red Crescent workers, i.e., Red Cross workers, and firefighters) with university student volunteers who had no formal training in handling traumatic situations in the Bam earthquake. One hundred student volunteers, 18 Red Crescent workers, and 36 firefighters participated in this study. Participants completed the Civilian Mississippi Scale, the General Health Questionnaire (GHQ-28), and the Anxiety Sensitivity Index. Helpers without formal training showed higher scores on posttraumatic stress disorder (PTSD) and GHQ subscales compared to trained rescue personnel. In addition, a significant number of volunteers without formal training met criteria for a possible PTSD diagnosis by scoring above the cut-off point for the Mississippi scale. Those who had higher scores on the Anxiety Sensitivity Index showed greater adverse psychological effects.