Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 69
Filtrar
1.
BMC Infect Dis ; 24(1): 1051, 2024 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-39333907

RESUMEN

The Hybrid NAR-RBFs Networks for COVID-19 fractional order model is examined in this scientific study. Hybrid NAR-RBFs Networks for COVID-19, that is more infectious which is appearing in numerous areas as people strive to stop the COVID-19 pandemic. It is crucial to figure out how to create strategies that would stop the spread of COVID-19 with a different age groups. We used the epidemic scenario in the Hybrid NAR-RBFs Networks as a case study in order to replicate the propagation of the modified COVID-19. In this research work, existence and stability are verified for COVID-19 as well as proved unique solutions by applying some results of fixed point theory. The developed approach to investigate the impact of Hybrid NAR-RBFs Networks due to COVID-19 at different age groups is relatively advanced. Also obtain solutions for a proposed model by utilizing Atanga Toufik technique and fractal fractional which are the advanced techniques for such type of infectious problems for continuous monitoring of spread of COVID-19 in different age groups. Comparisons has been made to check the efficiency of techniques as well as for finding the reliable solutions to understand the dynamical behavior of Hybrid NAR-RBFs Networks for non-linear COVID-19. Finally, the parameters are evaluated to see the impact of illness and present numerical simulations using Matlab to see actual behavior of this infectious disease for Hybrid NAR-RBFs Networks of COVID-19 for different age groups.


Asunto(s)
COVID-19 , SARS-CoV-2 , COVID-19/epidemiología , COVID-19/transmisión , Humanos , Dinámicas no Lineales , Pandemias
2.
J Pak Med Assoc ; 74(9): 1732-1734, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39279094

RESUMEN

Atrial Myxoma is the most common primary benign tumour of the heart, commonly found in the left atrium. It typically presents in young females with characteristic features such as, constitutional symptoms, chest pain, and cardiac murmurs. However, atypical presentations can occur; causing a diagnostic challenge. This case report describes a 75-year-old male who visited the cardiology outpatient department of Dow Institute of Cardiology, Karachi on 18th April, 2023 with a left-sided atrial myxoma in late adulthood without typical features including constitutional symptoms, chest pain, syncope, dizziness, digital clubbing or neurologic findings. Further discussed are the diagnostic techniques used to find the tumour and the treatment strategy. This case report highlights the need for cardiologists to consider Atrial Myxoma as a potential diagnosis, even in the absence of typical symptoms, in elderly male population.


Asunto(s)
Atrios Cardíacos , Neoplasias Cardíacas , Mixoma , Humanos , Mixoma/cirugía , Mixoma/diagnóstico , Masculino , Neoplasias Cardíacas/cirugía , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/diagnóstico por imagen , Anciano , Atrios Cardíacos/diagnóstico por imagen , Atrios Cardíacos/patología , Ecocardiografía
3.
Artículo en Inglés | MEDLINE | ID: mdl-39300871

RESUMEN

The global population has encountered significant challenges throughout history due to infectious diseases. To comprehensively study these dynamics, a novel deterministic mathematical model, TCD IL2 Z, is developed for the early detection and treatment of lung cancer. This model incorporates IL2 cytokine and anti-PD-L1 inhibitors, enhancing the immune system's anticancer response within five epidemiological compartments. The TCD IL2Z model is analyzed qualitatively and quantitatively, emphasizing local stability given the limited data-a critical component of epidemic modeling. The model is systematically validated by examining essential elements such as equilibrium points, the reproduction number (R0), stability, and sensitivity analysis. Next-generation techniques based on R0 that track disease transmission rates across the sub-compartments are fed into the system. At the same time, sensitivity analysis helps model how a particular parameter affects the dynamics of the system. The stability on the global level of such therapy agents retrogrades individuals with immunosuppression or treated with IL2 and anti-PD-L1 inhibitors admiring the Lyapunov functions' applications. NSFD scheme based on the implicit method is used to find the exact value and is compared with Euler's method and RK4, which guarantees accuracy. Thus, the simulations were conducted in the MATLAB environment. These simulations present the general symptomatic and asymptomatic consequences of lung cancer globally when detected in the middle and early stages, and measures of anticancer cells are implemented including boosting the immune system for low immune individuals. In addition, such a result provides knowledge about real-world control dynamics with IL2 and anti-PD-L1 inhibitors. The studies will contribute to the understanding of disease spread patterns and will provide the basis for evidence-based intervention development that will be geared toward actual outcomes.

4.
Comput Methods Programs Biomed ; 257: 108420, 2024 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-39303363

RESUMEN

BACKGROUND AND OBJECTIVES: In this paper, we developed a significant class of control issues regulated by nonlinear fractal order systems with input and output signals, our goal is to design a direct transcription method with impulsive instant order. Recent advances in the artificial pancreas system provide an emerging treatment option for type 1 diabetes. The performance of the blood glucose regulation directly relies on the accuracy of the glucose-insulin modeling. This work leads to the monitoring and assessment of comprehensive type-1 diabetes mellitus for controller design of artificial panaceas for the precision of the glucose-insulin glucagon in finite time with Caputo fractional approach for three primary subsystems. METHODS: For the proposed model, we admire the qualitative analysis with equilibrium points lying in the feasible region. Model satisfied the biological feasibility with the Lipschitz criteria and linear growth is examined, considering positive solutions, boundedness and uniqueness at equilibrium points with Leray-Schauder results under time scale ideas. Within each subsystem, the virtual control input laws are derived by the application of input to state theorems and Ulam Hyers Rassias. RESULTS: Chaotic Relation of Glucose insulin glucagon compartmental in the feasible region and stable in finite time interval monitoring is derived through simulations that are stable and bounded in the feasible regions. Additionally, as blood glucose is the only measurable state variable, the unscented power-law kernel estimator appropriately takes into account the significant problem of estimating inaccessible state variables that are bound to significant values for the glucose-insulin system. The comparative results on the simulated patients suggest that the suggested controller strategy performs remarkably better than the compared methods. CONCLUSION: In the model under investigation, parametric uncertainties are identified since the glucose, insulin, and glucagon system's parameters are accurately measured numerically at different fractional order values. In terms of algorithm resilience and Caputo tracking in the presence of glucagon and insulin intake disturbance to maintain the glucose level. A comprehensive analysis of numerous difficult test issues is conducted in order to offer a thorough justification of the planned strategy to control the type 1 diabetes mellitus with designed the artificial pancreas.

5.
PLoS One ; 19(8): e0307732, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39208269

RESUMEN

In this research, we developed an epidemic model with a combination of Atangana-Baleanu Caputo derivative and classical operators for the hybrid operator's memory effects, allowing us to observe the dynamics and treatment effects at different time phases of syphilis infection caused by sex. The developed model properties, which take into account linear growth and Lipschitz requirements relating the rate of effects within its many sub-compartments according to the equilibrium points, include positivity, unique solution, exitance, and boundedness in the feasible domain. After conducting sensitivity analysis with various parameters influencing the model for the piecewise fractional operator, the reproductive number R0 for the biological viability of the model is determined. Generalized Ulam-Hyers stability results are employed to preserve global stability. The investigated model thus has a unique solution in the specified subinterval in light of the Banach conclusion, and contraction as a consequence holds for the Atangana-Baleanu Caputo derivative with classical operators. The piecewise model that has been suggested has a maximum of one solution. For numerical solutions, piecewise fractional hybrid operators at various fractional order values are solved using the Newton polynomial interpolation method. A comparison is also made between Caputo operator and the piecewise derivative proposed operator. This work improves our knowledge of the dynamics of syphilis and offers a solid framework for assessing the effectiveness of interventions for planning and making decisions to manage the illness.


Asunto(s)
Epidemias , Sífilis , Humanos , Sífilis/epidemiología , Sífilis/transmisión , Masculino , Modelos Epidemiológicos , Femenino , Número Básico de Reproducción
6.
Sci Rep ; 14(1): 18531, 2024 08 09.
Artículo en Inglés | MEDLINE | ID: mdl-39122819

RESUMEN

The number of Methicillin-resistant Staphylococcus aureus (MRSA) cases in communities and hospitals is on the rise worldwide. In this work, a nonlinear deterministic model for the dynamics of MRSA infection in society was developed to visualize the significance of awareness in interventions that could be applied in the prevention of transmission with and without optimal control. Positivity and uniqueness were verified for the proposed corruption model to identify the level of resolution of infection factors in society. Furthermore, how various parameters affect the reproductive number R 0 and sensitivity analysis of the proposed model was explored through mathematical techniques and figures. The global stability of model equilibria analysis was established by using Lyapunov functions with the first derivative test. A total of seven years of data gathered from a private hospital consisting of inpatients and outpatients of MRSA were used in this model for numerical simulations and for observing the dynamics of infection by using a non-standard finite difference (NSFD) scheme. When optimal control was applied as a second model, it was determined that increasing awareness of hand hygiene and wearing a mask were the key controlling measures to prevent the spread of community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA). Lastly, it was concluded that both CA-MRSA and HA-MRSA cases are on the rise in the community, and increasing awareness concerning transmission is extremely significant in preventing further spread.


Asunto(s)
Infección Hospitalaria , Staphylococcus aureus Resistente a Meticilina , Infecciones Estafilocócicas , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Humanos , Infecciones Estafilocócicas/epidemiología , Infecciones Estafilocócicas/prevención & control , Infecciones Estafilocócicas/microbiología , Prevalencia , Chipre/epidemiología , Infección Hospitalaria/prevención & control , Infección Hospitalaria/epidemiología , Infección Hospitalaria/microbiología , Infecciones Comunitarias Adquiridas/prevención & control , Infecciones Comunitarias Adquiridas/epidemiología , Infecciones Comunitarias Adquiridas/microbiología , Infecciones Comunitarias Adquiridas/transmisión , Concienciación , Modelos Teóricos , Higiene de las Manos
7.
PLoS One ; 19(7): e0307388, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39024307

RESUMEN

These days, fractional calculus is essential for studying the dynamic transmission of illnesses, developing control systems, and solving several other real-world issues. In this study, we develop a Hepatitis B (HBV) model to observe the dynamics of vaccination and treatment effects to control the disease by using novel fractional operator. Modified Atangana-Baleanu-Caputo (MABC) is a new definition of the used derivative that is based on a modification of the Atangana and Baleanu derivatives. By employing the MABC fractional derivative, which incorporates the concepts of non-locality and memory effects our model captures the complex dynamics of HBV transmission more accurately than traditional models. An objective of this study is to analyze the effect of immunization and treatment techniques on the course of the hepatitis B virus, with a particular focus on the changing order of differentiation. Thereby, our paper deals with the stability analysis, positiveness, existence and uniqueness of the solution and simulations. Analysis of reproductive number R0 with the impact of different parameters is also treated. The proposed model's existence and uniqueness findings are examined through the use of Banach's fixed point and Leray-Schauder nonlinear alternative theorems. The equilibria for the models are determined to be globally stable using Lyapunov functions. The simulations for certain parameters are achieved by applying the Lagrange interpolation for the numerical computations and also the results are compared with the ABC operator results. The model is validated using numerical simulations, which are also used to assess how well different intervention techniques work to lower the impact of HBV infection and prevent its spread throughout the community. The results of this research assist in developing public health policies intended to lower the incidence of HBV infection worldwide and offer insightful information about how well treatment and vaccination strategies work to prevent HBV disease.


Asunto(s)
Vacunas contra Hepatitis B , Hepatitis B , Vacunación , Humanos , Hepatitis B/prevención & control , Vacunas contra Hepatitis B/administración & dosificación , Vacunas contra Hepatitis B/uso terapéutico , Virus de la Hepatitis B , Modelos Teóricos , Simulación por Computador
8.
Sci Rep ; 14(1): 16257, 2024 07 15.
Artículo en Inglés | MEDLINE | ID: mdl-39009619

RESUMEN

In order to comprehend the dynamics of disease propagation within a society, mathematical formulations are essential. The purpose of this work is to investigate the diagnosis and treatment of lung cancer in persons with weakened immune systems by introducing cytokines ( I L 2 & I L 12 ) and anti-PD-L1 inhibitors. To find the stable position of a recently built system TCD I L 2 I L 12 Z, a qualitative and quantitative analysis are taken under sensitive parameters. Reliable bounded findings are ensured by examining the generated system's boundedness, positivity, uniqueness, and local stability analysis, which are the crucial characteristics of epidemic models. The positive solutions with linear growth are shown to be verified by the global derivative, and the rate of impact across every sub-compartment is determined using Lipschitz criteria. Using Lyapunov functions with first derivative, the system's global stability is examined in order to evaluate the combined effects of cytokines and anti-PD-L1 inhibitors on people with weakened immune systems. Reliability is achieved by employing the Mittag-Leffler kernel in conjunction with a fractal-fractional operator because FFO provide continuous monitoring of lung cancer in multidimensional way. The symptomatic and asymptomatic effects of lung cancer sickness are investigated using simulations in order to validate the relationship between anti-PD-L1 inhibitors, cytokines, and the immune system. Also, identify the actual state of lung cancer control with early diagnosis and therapy by introducing cytokines and anti-PD-L1 inhibitors, which aid in the patients' production of anti-cancer cells. Investigating the transmission of illness and creating control methods based on our validated results will both benefit from this kind of research.


Asunto(s)
Antígeno B7-H1 , Linfocitos T CD8-positivos , Neoplasias Pulmonares , Humanos , Linfocitos T CD8-positivos/inmunología , Neoplasias Pulmonares/inmunología , Neoplasias Pulmonares/tratamiento farmacológico , Antígeno B7-H1/antagonistas & inhibidores , Antígeno B7-H1/inmunología , Antígeno B7-H1/metabolismo , Citocinas/metabolismo , Inhibidores de Puntos de Control Inmunológico/uso terapéutico , Inhibidores de Puntos de Control Inmunológico/farmacología , Simulación por Computador
9.
Sci Rep ; 14(1): 16489, 2024 07 17.
Artículo en Inglés | MEDLINE | ID: mdl-39019935

RESUMEN

COVID-19 is linked to diabetes, increasing the likelihood and severity of outcomes due to hyperglycemia, immune system impairment, vascular problems, and comorbidities like hypertension, obesity, and cardiovascular disease, which can lead to catastrophic outcomes. The study presents a novel COVID-19 management approach for diabetic patients using a fractal fractional operator and Mittag-Leffler kernel. It uses the Lipschitz criterion and linear growth to identify the solution singularity and analyzes the global derivative impact, confirming unique solutions and demonstrating the bounded nature of the proposed system. The study examines the impact of COVID-19 on individuals with diabetes, using global stability analysis and quantitative examination of equilibrium states. Sensitivity analysis is conducted using reproductive numbers to determine the disease's status in society and the impact of control strategies, highlighting the importance of understanding epidemic problems and their properties. This study uses two-step Lagrange polynomial to analyze the impact of the fractional operator on a proposed model. Numerical simulations using MATLAB validate the effects of COVID-19 on diabetic patients and allow predictions based on the established theoretical framework, supporting the theoretical findings. This study will help to observe and understand how COVID-19 affects people with diabetes. This will help with control plans in the future to lessen the effects of COVID-19.


Asunto(s)
COVID-19 , Coinfección , Diabetes Mellitus , Fractales , SARS-CoV-2 , COVID-19/epidemiología , COVID-19/complicaciones , COVID-19/virología , Humanos , Diabetes Mellitus/epidemiología , Diabetes Mellitus/virología , Coinfección/virología , Coinfección/epidemiología , SARS-CoV-2/aislamiento & purificación , Simulación por Computador
10.
Comput Biol Med ; 178: 108756, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38901190

RESUMEN

BACKGROUND: Tuberculosis, a global health concern, was anticipated to grow to 10.6 million new cases by 2021, with an increase in multidrug-resistant tuberculosis. Despite 1.6 million deaths in 2021, present treatments save millions of lives, and tuberculosis may overtake COVID-19 as the greatest cause of mortality. This study provides a six-compartmental deterministic model that employs a fractal-fractional operator with a power law kernel to investigate the impact of vaccination on tuberculosis dynamics in a population. METHODS: Some important characteristics, such as vaccination and infection rate, are considered. We first show that the suggested model has positive bounded solutions and a positive invariant area. We evaluate the equation for the most important threshold parameter, the basic reproduction number, and investigate the model's equilibria. We perform sensitivity analysis to determine the elements that influence tuberculosis dynamics. Fixed-point concepts show the presence and uniqueness of a solution to the suggested model. We use the two-step Newton polynomial technique to investigate the effect of the fractional operator on the generalized form of the power law kernel. RESULTS: The stability analysis of the fractal-fractional model has been confirmed for both Ulam-Hyers and generalized Ulam-Hyers types. Numerical simulations show the effects of different fractional order values on tuberculosis infection dynamics in society. According to numerical simulations, limiting contact with infected patients and enhancing vaccine efficacy can help reduce the tuberculosis burden. The fractal-fractional operator produces better results than the ordinary integer order in the sense of memory effect at diffract fractal and fractional order values. CONCLUSION: According to our findings, fractional modeling offers important insights into the dynamic behavior of tuberculosis disease, facilitating a more thorough comprehension of their epidemiology and possible means of control.


Asunto(s)
COVID-19 , Simulación por Computador , Fractales , Tuberculosis , Humanos , Tuberculosis/epidemiología , Tuberculosis/prevención & control , COVID-19/prevención & control , COVID-19/epidemiología , SARS-CoV-2 , Prevalencia , Modelos Biológicos
11.
Sci Rep ; 14(1): 10927, 2024 05 13.
Artículo en Inglés | MEDLINE | ID: mdl-38740856

RESUMEN

To study the dynamical system, it is necessary to formulate the mathematical model to understand the dynamics of various diseases which are spread in the world wide. The objective of the research study is to assess the early diagnosis and treatment of cholera virus by implementing remedial methods with and without the use of drugs. A mathematical model is built with the hypothesis of strengthening the immune system, and a ABC operator is employed to turn the model into a fractional-order model. A newly developed system SEIBR, which is examined both qualitatively and quantitatively to determine its stable position as well as the verification of flip bifurcation has been made for developed system. The local stability of this model has been explored concerning limited observations, a fundamental aspect of epidemic models. We have derived the reproductive number using next generation method, denoted as " R 0 ", to analyze its impact rate across various sub-compartments, which serves as a critical determinant of its community-wide transmission rate. The sensitivity analysis has been verified according to its each parameters to identify that how much rate of change of parameters are sensitive. Atangana-Toufik scheme is employed to find the solution for the developed system using different fractional values which is advanced tool for reliable bounded solution. Also the error analysis has been made for developed scheme. Simulations have been made to see the real behavior and effects of cholera disease with early detection and treatment by implementing remedial methods without the use of drugs in the community. Also identify the real situation the spread of cholera disease after implementing remedial methods with and without the use of drugs. Such type of investigation will be useful to investigate the spread of virus as well as helpful in developing control strategies from our justified outcomes.


Asunto(s)
Cólera , Modelos Teóricos , Cólera/epidemiología , Humanos , Epidemias/prevención & control , Simulación por Computador
12.
Comput Methods Programs Biomed ; 250: 108190, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38688140

RESUMEN

BACKGROUND AND OBJECTIVE: To study the dynamical system, it is necessary to formulate the mathematical model to understand the dynamics of various diseases that are spread worldwide. The main objective of our work is to examine neurological disorders by early detection and treatment by taking asymptomatic. The central nervous system (CNS) is impacted by the prevalent neurological condition known as multiple sclerosis (MS), which can result in lesions that spread across time and place. It is widely acknowledged that multiple sclerosis (MS) is an unpredictable disease that can cause lifelong damage to the brain, spinal cord, and optic nerves. The use of integral operators and fractional order (FO) derivatives in mathematical models has become popular in the field of epidemiology. METHOD: The model consists of segments of healthy or barian brain cells, infected brain cells, and damaged brain cells as a result of immunological or viral effectors with novel fractal fractional operator in sight Mittag Leffler function. The stability analysis, positivity, boundedness, existence, and uniqueness are treated for a proposed model with novel fractional operators. RESULTS: Model is verified the local and global with the Lyapunov function. Chaos Control will use the regulate for linear responses approach to bring the system to stabilize according to its points of equilibrium so that solutions are bounded in the feasible domain. To ensure the existence and uniqueness of the solutions to the suggested model, it makes use of Banach's fixed point and the Leray Schauder nonlinear alternative theorem. For numerical simulation and results the steps Lagrange interpolation method at different fractional order values and the outcomes are compared with those obtained using the well-known FFM method. CONCLUSION: Overall, by offering a mathematical model that can be used to replicate and examine the behavior of disease models, this research advances our understanding of the course and recurrence of disease. Such type of investigation will be useful to investigate the spread of disease as well as helpful in developing control strategies from our justified outcomes.


Asunto(s)
Esclerosis Múltiple , Dinámicas no Lineales , Humanos , Encéfalo/fisiopatología , Enfermedades del Sistema Nervioso , Simulación por Computador , Modelos Teóricos , Algoritmos , Modelos Neurológicos , Fractales
13.
Sci Rep ; 14(1): 8058, 2024 04 05.
Artículo en Inglés | MEDLINE | ID: mdl-38580678

RESUMEN

In this paper, we propose a fractional-order mathematical model to explain the role of glucagon in maintaining the glucose level in the human body by using a generalised form of a fractal fractional operator. The existence, boundedness, and positivity of the results are constructed by fixed point theory and the Lipschitz condition for the biological feasibility of the system. Also, global stability analysis with Lyapunov's first derivative functions is treated. Numerical simulations for fractional-order systems are derived with the help of Lagrange interpolation under the Mittage-Leffler kernel. Results are derived for normal and type 1 diabetes at different initial conditions, which support the theoretical observations. These results play an important role in the glucose-insulin-glucagon system in the sense of a closed-loop design, which is helpful for the development of artificial pancreas to control diabetes in society.


Asunto(s)
Diabetes Mellitus Tipo 1 , Insulinas , Humanos , Glucagón , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Modelos Teóricos , Glucosa
14.
PLoS One ; 19(4): e0298620, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38625847

RESUMEN

In this manuscript, we developed a nonlinear fractional order Ebola virus with a novel piecewise hybrid technique to observe the dynamical transmission having eight compartments. The existence and uniqueness of a solution of piecewise derivative is treated for a system with Arzel'a-Ascoli and Schauder conditions. We investigate the effects of classical and modified fractional calculus operators, specifically the classical Caputo piecewise operator, on the behavior of the model. A model shows that a completely continuous operator is uniformly continuous, and bounded according to the equilibrium points. The reproductive number R0 is derived for the biological feasibility of the model with sensitivity analysis with different parameters impact on the model. Sensitivity analysis is an essential tool for comprehending how various model parameters affect the spread of illness. Through a methodical manipulation of important parameters and an assessment of their impact on Ro, we are able to learn more about the resiliency and susceptibility of the model. Local stability is established with next Matignon method and global stability is conducted with the Lyapunov function for a feasible solution of the proposed model. In the end, a numerical solution is derived with Newton's polynomial technique for a piecewise Caputo operator through simulations of the compartments at various fractional orders by using real data. Our findings highlight the importance of fractional operators in enhancing the accuracy of the model in capturing the intricate dynamics of the disease. This research contributes to a deeper understanding of Ebola virus dynamics and provides valuable insights for improving disease modeling and public health strategies.


Asunto(s)
Ebolavirus , Epidemias , Fiebre Hemorrágica Ebola , Humanos , Fiebre Hemorrágica Ebola/epidemiología , Aprendizaje , Salud Pública
15.
AIMS Public Health ; 11(1): 19-35, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38617407

RESUMEN

Among women of reproductive age, PCOS (polycystic ovarian syndrome) is one of the most prevalent endocrine illnesses. In addition to decreasing female fertility, this condition raises the risk of cardiovascular disease, diabetes, dyslipidemia, obesity, psychiatric disorders and other illnesses. In this paper, we constructed a fractional order model for polycystic ovarian syndrome by using a novel approach with the memory effect of a fractional operator. The study population was divided into four groups for this reason: Women who are at risk for infertility, PCOS sufferers, infertile women receiving therapy (gonadotropin and clomiphene citrate), and improved infertile women. We derived the basic reproductive number, and by utilizing the Jacobian matrix and the Routh-Hurwitz stability criterion, it can be shown that the free and endemic equilibrium points are both locally stable. Using a two-step Lagrange polynomial, solutions were generated in the generalized form of the power law kernel in order to explore the influence of the fractional operator with numerical simulations, which shows the impact of the sickness on women due to the effect of different parameters involved.

16.
PLoS One ; 19(3): e0299560, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38483931

RESUMEN

Mathematical formulations are crucial in understanding the dynamics of disease spread within a community. The aim of this work is to examine that the Lung Cancer detection and treatment by introducing IL2 and anti-PD-L1 inhibitor for low immune individuals. Mathematical model is developed with the created hypothesis to increase immune system by antibody cell's and Fractal-Fractional operator (FFO) is used to turn the model into a fractional order model. A newly developed system TCDIL2Z is examined both qualitatively and quantitatively in order to determine its stable position. The boundedness, positivity and uniqueness of the developed system are examined to ensure reliable bounded findings, which are essential properties of epidemic models. The global derivative is demonstrated to verify the positivity with linear growth and Lipschitz conditions are employed to identify the rate of effects in each sub-compartment. The system is investigated for global stability using Lyapunov first derivative functions to assess the overall impact of IL2 and anti-PD-L1 inhibitor for low immune individuals. Fractal fractional operator is used to derive reliable solution using Mittag-Leffler kernel. In fractal-fractional operators, fractal represents the dimensions of the spread of the disease and fractional represents the fractional ordered derivative operator. We use combine operators to see real behavior of spread as well as control of lung cancer with different dimensions and continuous monitoring. Simulations are conducted to observe the symptomatic and asymptomatic effects of Lung Cancer disease to verify the relationship of IL2, anti-PD-L1 inhibitor and immune system. Also identify the real situation of the control for lung cancer disease after detection and treatment by introducing IL2 cytokine and anti-PD-L1 inhibitor which helps to generate anti-cancer cells of the patients. Such type of investigation will be useful to investigate the spread of disease as well as helpful in developing control strategies from our justified outcomes.


Asunto(s)
Interleucina-2 , Neoplasias Pulmonares , Humanos , Neoplasias Pulmonares/tratamiento farmacológico , Citocinas , Modelos Teóricos , Fractales
17.
Comput Biol Med ; 173: 108367, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38555706

RESUMEN

Bacterial infections in the health-care sector and social environments have been linked to the Methicillin-Resistant Staphylococcus aureus (MRSA) infection, a type of bacteria that has remained an international health risk since the 1960s. From mild colonization to a deadly invasive disease with an elevated mortality rate, the illness can present in many different forms. A fractional-order dynamic model of MRSA infection developed using real data for computational and modeling analysis on the north side of Cyprus is presented in this paper. Initially, we tested that the suggested model had a positively invariant region, bounded solutions, and uniqueness for the biological feasibility of the model. We study the equilibria of the model and assess the expression for the most significant threshold parameter, called the basic reproduction number (ℛ0). The reproductive number's parameters are also subjected to sensitivity analysis through mathematical methods and simulations. Additionally, utilizing the power law kernel and the fixed-point approach, the existence, uniqueness, and generalized Ulam-Hyers-Rassias stability are presented. Chaos Control was used to regulate the linear responses approach to bring the system to stabilize according to its points of equilibrium, taking into account a fractional-order system with a managed design where solutions are bound in the feasible domain. Finally, numerical simulations demonstrating the effects of different parameters on MRSA infection are used to investigate the impact of the fractional operator on the generalized form of the power law kernel through a two-step Newton polynomial method. The impact of fractional orders is emphasized in the study so that the numerical solutions support the importance of these orders on MRSA infection. With the application of fractional order, the significance of cognizant antibiotic usage for MRSA infection is verified.


Asunto(s)
Staphylococcus aureus Resistente a Meticilina , Bacterias , Antibacterianos
19.
Sci Rep ; 14(1): 2175, 2024 01 25.
Artículo en Inglés | MEDLINE | ID: mdl-38272984

RESUMEN

Respiratory syncytial virus (RSV) is the cause of lung infection, nose, throat, and breathing issues in a population of constant humans with super-spreading infected dynamics transmission in society. This research emphasizes on examining a sustainable fractional derivative-based approach to the dynamics of this infectious disease. We proposed a fractional order to establish a set of fractional differential equations (FDEs) for the time-fractional order RSV model. The equilibrium analysis confirmed the existence and uniqueness of our proposed model solution. Both sensitivity and qualitative analysis were employed to study the fractional order. We explored the Ulam-Hyres stability of the model through functional analysis theory. To study the influence of the fractional operator and illustrate the societal implications of RSV, we employed a two-step Lagrange polynomial represented in the generalized form of the Power-Law kernel. Also, the fractional order RSV model is demonstrated with chaotic behaviors which shows the trajectory path in a stable region of the compartments. Such a study will aid in the understanding of RSV behavior and the development of prevention strategies for those who are affected. Our numerical simulations show that fractional order dynamic modeling is an excellent and suitable mathematical modeling technique for creating and researching infectious disease models.


Asunto(s)
Enfermedades Transmisibles , Infecciones por Virus Sincitial Respiratorio , Virus Sincitial Respiratorio Humano , Humanos , Cuello , Nariz
20.
Sci Rep ; 13(1): 22441, 2023 12 17.
Artículo en Inglés | MEDLINE | ID: mdl-38105260

RESUMEN

Marine structure changes as a result of climate change, with potential biological implications for human societies and marine ecosystems. These changes include changes in temperatures, flow, discrimination, nutritional inputs, oxygen availability, and acidification of the ocean. In this study, a fractional-order model is constructed using the Caputo fractional operator, which singular and nol-local kernel. A model examines the effects of accelerating global warming on aquatic ecosystems while taking into account variables that change over time, such as the environment and organisms. The positively invariant area also demonstrates positive, bounded solutions of the model treated. The equilibrium states for the occurrence and extinction of fish populations are derived for a feasible solution of the system. We also used fixed-point theorems to analyze the existence and uniqueness of the model. The generalized Ulam-Hyers-Rassias function is used to analyze the stability of the system. To study the impact of the fractional operator through computational simulations, results are generated employing a two-step Lagrange polynomial in the generalized version for the power law kernel and also compared the results with an exponential law and Mittag Leffler kernel. We also produce graphs of the model at various fractional derivative orders to illustrate the important influence that the fractional order has on the different classes of the model with the memory effects of the fractional operator. To help with the oversight of fisheries, this research builds mathematical connections between the natural world and aquatic ecosystems.


Asunto(s)
Ecosistema , Calentamiento Global , Animales , Humanos , Cambio Climático , Explotaciones Pesqueras , Oxígeno
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...