Seroepidemiologic Investigation of a COVID-19 Outbreak Aboard a U.S. Navy Ship.

The crew of USS Kidd experienced a COVID-19 outbreak identified in April 2020. This is the earliest documented COVID-19 study with RT-PCR, serology, and pre-exposure test data on the entirety of the exposed population (n=333). Case definitions included 121 confirmed (36.3% of crewmembers) and 18 probable (5.4% of crewmembers) based on laboratory diagnostic test results. At the time of testing positive, 62 (44.6%) cases reported no symptoms. Hispanic ethnicity (AOR: 2.71, CI: 1.40-5.25) and non-smoker status (AOR: 2.28, CI: 1.26-4.12) were identified as statistically significant risk factors. This study highlights the value of rapid, onboard diagnostic testing to quickly identify an outbreak and enumerate cases, as well as the serological testing to flag potential cases missed with standard viral case identification methodologies.

Smoking cessation and improvement in physical performance among young men.

Tobacco use among young adults is a major public health challenge. Near-term benefits of cessation may motivate active young people to quit or avoid smoking. Military basic training includes mandatory tobacco cessation, as well as uniform physical conditioning regimes, creating an opportunity to evaluate changes in physical performance metrics in direct relation to smoking cessation. These analyses included data from all men who completed Marine Corps recruit training in San Diego, California, between 2002 and 2006. Recruits reported tobacco use and other health metrics on a pretraining survey. Initial and final aerobic run-times were recorded over the 3-month training period. Multivariable linear regression analyses assessed changes in run-speed relative to pre-enlistment smoking history. Among 52,419 young men included in analyses, 13,248 (25.3%) reported smoking before enlistment. Average run-speeds improved among all groups of recruits; however, improvement was greater among prior smokers compared to recruits with no history of smoking (average increase of 0.31 vs. 0.21 miles per hour) and statistically significant in multivariate analyses. Smoking cessation in this cohort of young men resulted in improved physical aerobic performance, independent of other behavioral health characteristics. These data may be useful in promoting and motivating smoking cessation among young, active adults.

Does maternal hypoglycemia during screening glucose assessment identify a pregnancy at-risk for adverse perinatal outcome?

OBJECTIVE: To determine the perinatal outcome in pregnancies with maternal hypoglycemia following a second trimester oral glucose challenge test (GCT). STUDY DESIGN: Retrospective case-control study of pregnancies undergoing a second trimester 1-hour oral glucose challenge test (GCT). Hypoglycemic pregnancies (<88 mg/dl) were matched with pregnancies with 1-hour glucoses of >88 mg/dl. Antepartum, intrapartum, and neonatal outcomes were assessed. RESULTS: Over 29 months, 334 hypoglycemic singleton pregnancies were matched with 334 controls. A greater number of special/neonatal intensive care unit (SCN/NICU) admissions occurred in the hypoglycemic group (48/334 (14.4%) vs 29/334 (8.7%) in the control group) (p=0.02). The SCN/NICU admission rate remained after controlling for maternal hypertension, smoking, and preterm birth (p=0.037). The development of pregnancy-induced hypertension in women with hypoglycemia 24/334 (7.2%) compared with euglycemic women 13/334 (3.9%, p<0.06) was not significant. CONCLUSION: Admission to SCN/NICU is increased in pregnant women with hypoglycemia following a GCT.