Therapeutic indications, chemical composition and biological activity of native Brazilian species from Psidium genus (Myrtaceae): A review.

ETHNOPHARMACOLOGICAL IMPORTANCE: Brazilian medicinal species of the Psidium genus are rich in secondary metabolites such as terpenes and phenolic compounds and present biological activities for several human diseases. For the native Psidium species, there are no specific research reports for any member of the genus about ethnobotanical research, hindering the joint analysis of its therapeutic indications together with the scientific evidence already investigated. STUDY OBJECTIVE: Analyze the therapeutic indications, the main chemical constituents, and the biological activities of native species of the Psidium to Brazil. MATERIALS AND METHODS: Systematic research was carried out in the Scopus, ScienceDirect, PubMed, and Web of Science databases over a period of ten years. Articles in English, Portuguese and Spanish were used. The research was divided into three phases, seeking information on ethnobotany, chemical composition and biological activities. The words were combined to structure the descriptors used in the search. RESULTS: A total of 13 native species belonging to the Psidium genus were identified in this analysis, Psidium acutangulum DC., Psidium brownianum Mart. ex DC., Psidium cattleyanum Sabine, Psidium densicomum Mart. ex DC., Psidium grandifolium Mart. ex DC., Psidium guineense Sw., Psidium laruotteanum Cambess., Psidium myrsinites DC, Psidium myrtoides O. Berg, Psidium salutare (Kunth) O. Berg, Psidium schenckianum Kiaersk., Psidium sobralianum Proença & Landrum, Psidium striatulum Mart. ex DC. Of these, six were indicated in folk medicine, digestive system disorders being their main therapeutic indication. Most species presented an investigation of chemical composition and biological activity. They are rich in phenolic compounds, flavonoids, and terpenes and have antimicrobial, antioxidant, antiproliferative, and repellent activities. CONCLUSIONS: Native species of the Psidium genus are important sources of active ingredients in combating adversities that affect the human health, especially regarding the digestive system. They have a rich chemical composition, responsible for the biological activities demonstrated for the species.

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study.

ETHNOPHARMACOLOGICAL RELEVANCE: This study aims to evaluate the versatility of these species and their agreement of use and/or the informants' knowledge and verify the variability of the information on the indicated medicinal species in comparison to other species from northeastern Brazilian areas. MATERIALS AND METHODS: Ethnobotanical information was acquired through interviews with 23 residents of the Quincuncá community, northeastern Brazil. From the obtained data, a comparative analysis of the therapeutic indications with other 40 areas in different biomes was conducted. For that, the relative importance index and informant consensus factor were calculated and compared to other indices evaluated in the literature. RESULTS: A total of 39 medicinal species were cited and twenty-six species showed similarities among their therapeutic indications; however, species as Geoffroea spinosa, Lantana camara, and others can be highlighted, present in community disease indications that were not verified for other areas. Myracrodruon urundeuva, Mimosa tenuiflora, Stryphnodendron rotundifolium, and Amburana cearensis had the greatest versatility. In the Quincuncá community, medicinal species were indicated for 49 diseases, which were grouped into 15 categories of body systems. CONCLUSION: This study shows the presented divergence in relation to their therapeutic use; in this point, these divergences reinforce the importance of pharmacological research.