1.
Neurosci Behav Physiol
; 29(1): 7-10, 1999.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10088144
Asunto(s)
Encefalomielitis Autoinmune Experimental/patología , Esclerosis Múltiple/patología , Animales , Enfermedad Crónica , Ciclosporina/farmacología , Modelos Animales de Enfermedad , Cobayas , Inmunosupresores/farmacología , Vaina de Mielina/inmunología , Vaina de Mielina/patología , Ratas , Ratas Endogámicas Lew , Médula Espinal/inmunología , Médula Espinal/patología
2.
Morfologiia
; 112(6): 25-8, 1997.
Artículo
en Ruso
| MEDLINE
| ID: mdl-9606089
RESUMEN
Chronic relapsing experimental allergic encephalomyelitis (CR EAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's aduvant followed by treatment with low dose cyclosporin A. Histological, histochemical and electron microscopic studies of the lesions during the first and the second clinical episodes, as well as during the first and the second remissions, revealed inflammation, prominent demyelination, remyelination and gliosis in the central nervous system (CNS). This model of CR EAE in the Lewis rats may be a useful model for multiple sclerosis.