RESUMEN
Periprosthetic joint infection (PJI) is one of the most challenging complications a surgeon has to face after prosthetic replacement of a joint and one of the most devastating complications for the patient. During the 2018 International Consensus Meeting (ICM) in Philadelphia a numerical diagnostic tool was proposed. Contraindications to single stage revision include significant soft tissue injury with the inability to provide soft tissue cover, the presence of unknown or multi resistant organisms, lack of access to appropriate antibiotics or lack of appropriate expertise. Two stage revision surgery is indicated in these situations. Insall et al. described the surgical two-stage prosthetic revision technique in 1983: the in situ prosthesis is removed, a thorough debridement of bone and soft tissue is performed, an interval spacer is inserted, antibiotics administered. The 2nd stage of definitive reconstruction is performed once the infection is deemed to have resolved. The interval between stages can range from 6 weeks to several months. PJI are very challenging for every surgeon skilled in prosthetic surgery. It's necessary to make an exact preoperative diagnosis and to treat them with the proper technique. Further studies are needed to establish the perfect timing between the two stages, the duration of the antibiotic therapy and to standardize the diagnostic chart.
RESUMEN
Background: From 10 March up until 3 May 2020 in Northern Italy, the SARS-CoV-2 spread was not contained; disaster triage was adopted. The aim of the present study is to assess the impact of the COVID-19-pandemic on the Orthopedic and Trauma departments, focusing on: hospital reorganization (flexibility, workload, prevalence of COVID-19/SARS-CoV-2, standards of care); effects on staff; subjective orthopedic perception of the pandemic. Material and Methods: Data regarding 1390 patients and 323 surgeons were retrieved from a retrospective multicentric database, involving 14 major hospitals. The subjective directors' viewpoints regarding the economic consequences, communication with the government, hospital administration and other departments were collected. Results: Surgical procedures dropped by 73%, compared to 2019, elective surgery was interrupted. Forty percent of patients were screened for SARS-CoV-2: 7% with positive results. Seven percent of the patients received medical therapy for COVID-19, and only 48% of these treated patients had positive swab tests. Eleven percent of surgeons developed COVID-19 and 6% were contaminated. Fourteen percent of the staff were redirected daily to COVID units. Communication with the Government was perceived as adequate, whilst communication with medical Authorities was considered barely sufficient. Conclusions: Activity reduction was mandatory; the screening of carriers did not seem to be reliable and urgent activities were performed with a shortage of workers and a slower workflow. A trauma network and dedicated in-hospital paths for COVID-19-patients were created. This experience provided evidence for coordinated responses in order to avoid the propagation of errors.
Asunto(s)
COVID-19 , Procedimientos Ortopédicos , Cirujanos , Humanos , Italia/epidemiología , Pandemias , Estudios Retrospectivos , SARS-CoV-2RESUMEN
BACKGROUND: Periprosthetic fractures (PPFs) are a growing matter for orthopaedic surgeons, and patients with PPFs may represent a frail target in the case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of this study is to investigate whether hospital reorganisations during the most severe phase of the SARS-CoV-2 pandemic affected standards of care and early outcomes of patients treated for PPFs in Northern Italy. MATERIALS AND METHODS: Data were retrieved from a multicentre retrospective orthopaedics and traumatology database, including 14 hospitals. The following parameters were studied: demographics, results of nasopharyngeal swabs, prevalence of coronavirus disease 2019 (COVID-19), comorbidities, general health status (EQ-5D-5L Score), frailty (Clinical Frailty Scale, CFS), pain (visual analogue scale, VAS), anaesthesiologic risk (American Society of Anaesthesiology Score, ASA Score), classification (unified classification system, UCS), type of operation and anaesthesia, in-hospital and early complications (Clavien-Dindo Classification, CDC), and length of stay (LOS). Data were analysed by means of descriptive statistics. Out of 1390 patients treated for any reason, 38 PPFs were included. RESULTS: Median age was 81 years (range 70-96 years). Twenty-three patients (60.5%) were swabbed on admission, and two of them (5.3%) tested positive; in three patients (7.9%), the diagnosis of COVID-19 was established on a clinical and radiological basis. Two more patients tested positive post-operatively, and one of them died due to COVID-19. Thirty-three patients (86.8%) presented a proximal femoral PPF. Median ASA Score was 3 (range, 1-4), median VAS score on admission was 3 (range, 0-6), median CFS was 4 (range, 1-8), median EQ-5D-5L Score was 3 in each one of the categories (range, 1-5). Twenty-three patients (60.5%) developed post-operative complications, and median CDC grade was 3 (range, 1-5). The median LOS was 12.8 days (range 2-36 days), and 21 patients (55.3%) were discharged home. CONCLUSIONS: The incidence of PPFs did not seem to change during the lockdown. Patients were mainly elderly with comorbidities, and complications were frequently recorded post-operatively. Despite the difficult period for the healthcare system, hospitals were able to provide effective conventional surgical treatments for PPFs, which were not negatively influenced by the reorganisation. Continued efforts are required to optimise the treatment of these frail patients in the period of the pandemic, minimising the risk of contamination, and to limit the incidence of PPFs in the future. LEVEL OF EVIDENCE: IV.
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COVID-19 , Reestructuración Hospitalaria , Control de Infecciones , Pandemias , Fracturas Periprotésicas , Nivel de Atención , Anciano , Anciano de 80 o más Años , COVID-19/diagnóstico , COVID-19/epidemiología , COVID-19/prevención & control , Control de Enfermedades Transmisibles/métodos , Control de Enfermedades Transmisibles/normas , Control de Enfermedades Transmisibles/estadística & datos numéricos , Comorbilidad , Femenino , Fragilidad/epidemiología , Reestructuración Hospitalaria/organización & administración , Reestructuración Hospitalaria/normas , Reestructuración Hospitalaria/estadística & datos numéricos , Humanos , Incidencia , Control de Infecciones/métodos , Control de Infecciones/normas , Control de Infecciones/estadística & datos numéricos , Italia/epidemiología , Masculino , Procedimientos Ortopédicos/métodos , Procedimientos Ortopédicos/normas , Procedimientos Ortopédicos/estadística & datos numéricos , Pandemias/estadística & datos numéricos , Fracturas Periprotésicas/complicaciones , Fracturas Periprotésicas/epidemiología , Fracturas Periprotésicas/cirugía , Fracturas Periprotésicas/terapia , Estudios Retrospectivos , SARS-CoV-2 , Nivel de Atención/normas , Nivel de Atención/estadística & datos numéricosRESUMEN
BACKGROUND: Treatment of hip fractures during the coronavirus disease 2019 (COVID-19) pandemic has posed unique challenges for the management of COVID-19-infected patients and the maintenance of standards of care. The primary endpoint of this study is to compare the mortality rate at 1 month after surgery in symptomatic COVID-positive patients with that of asymptomatic patients. A secondary endpoint of the study is to evaluate, in the two groups of patients, mortality at 1 month on the basis of type of fracture and type of surgical treatment. MATERIALS AND METHODS: For this retrospective multicentre study, we reviewed the medical records of patients hospitalised for proximal femur fracture at 14 hospitals in Northern Italy. Two groups were formed: COVID-19-positive patients (C+ group) presented symptoms, had a positive swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and received treatment for COVID-19; COVID-19-negative patients (C- group) were asymptomatic and tested negative for SARS-CoV-2. The two groups were compared for differences in time to surgery, survival rate and complications rate. The follow-up period was 1 month. RESULTS: Of the 1390 patients admitted for acute care for any reason, 477 had a proximal femur fracture; 53 were C+ but only 12/53 were diagnosed as such at admission. The mean age was > 80 years, and the mean American Society of Anesthesiologists (ASA) score was 3 in both groups. There was no substantial difference in time to surgery (on average, 2.3 days for the C+ group and 2.8 for the C- group). As expected, a higher mortality rate was recorded for the C+ group but not associated with the type of hip fracture or treatment. No correlation was found between early treatment (< 48 h to surgery) and better outcome in the C+ group. CONCLUSIONS: Hip fracture in COVID-19-positive patients accounted for 11% of the total. On average, the time to surgery was > 48 h, which reflects the difficulty of maintaining normal workflow during a medical emergency such as the present pandemic and notwithstanding the suspension of non-urgent procedures. Hip fracture was associated with a higher 30-day mortality rate in COVID-19-positive patients than in COVID-19-negative patients. This fact should be considered when communicating with patients and/or their family. Our data suggest no substantial difference in hip fracture management between patients with or without COVID-19 infection. In this sample, the COVID-19-positive patients were generally asymptomatic at admission; therefore, routine screening is recommended. LEVEL OF EVIDENCE: Therapeutic study, level 4.
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COVID-19/epidemiología , Fracturas de Cadera/mortalidad , Pandemias , Anciano de 80 o más Años , Comorbilidad , Femenino , Hospitalización/tendencias , Humanos , Italia/epidemiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , SARS-CoV-2 , Tasa de Supervivencia/tendencias , Factores de TiempoRESUMEN
INTRODUCTION: The aim of this study was to investigate the mechanisms of periprosthetic fractures occurring as a result of a sideways fall in total hip arthroplasty patients, and to compare the predictions of numerical models in terms of load distribution on the implanted femur with clinical data. MATERIALS AND METHODS: 3 numerical models were built: 1 for intact femur and 2 for implanted femur with a straight stem (resembling PBF, Permedica) and with an anatomical stem (resembling ABG II, Stryker). 4 loading configurations were simulated; 1 simulates a vertical load, and 3 simulate a fall with impact on the greater trochanter in different directions. Stress state calculated in the implanted femur was compared for the 2 models with reference to the intact case. These were compared with clinical data collected at a single centre (Istituto Ortopedico Gaetano Pini, Milan, Italy) where 41 patients were investigated after periprosthetic fracture: 26 patients had a straight uncemented stem and 15 an anatomical uncemented stem. RESULTS: The maximum calculated strain in compression in the case of ABG II implanted femur was 2 times higher than in the presence of PBF stem in the vertical loading configuration. For configurations of sideways fall, in both models, there was a progressive increase of stress state in the bone with increasing angle. Simulations of sideways fall elicited results in accordance with clinical observations: due to the peculiar stem design and consequent state of stress in the bone, anatomical stems seem to induce trochanteric fractures more frequently, while for straight stems type B fractures are more likely to occur. CONCLUSIONS: Clinical findings confirmed numerical model predictions: stem design seems to highly influence distribution of stress in the bone and consequent localisation of the fracture site.
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Artroplastia de Reemplazo de Cadera , Fracturas del Fémur , Fracturas Periprotésicas , Artroplastia de Reemplazo de Cadera/efectos adversos , Fracturas del Fémur/etiología , Fracturas del Fémur/cirugía , Fémur/diagnóstico por imagen , Fémur/cirugía , Humanos , Italia , Fracturas Periprotésicas/diagnóstico por imagen , Fracturas Periprotésicas/etiología , Fracturas Periprotésicas/cirugíaRESUMEN
BACKGROUND: Infections remains the most feared complication in total hip arthroplasty (THA). New strategies of PJI prevention includes coating of conventional implants. Defensive Antibacterial Coating (DAC), an antibacterial hydrogel coating made of hyaluronan, poly-D and L-lactide can protect biomaterials as an effective barrier at the time of implantation. In addition, it can be used with topical antibiotics to prevent early colonisation of the implant. SCOPE: This manuscript describes the detailed function of the DAC in general as well as an analysis of its use in revision THA in a series of 28 patients in a short-term follow-up.Its use in patients undergoing cementless re-implantation after 2-staged procedures in THA is described in detail within the manuscript. CONCLUSION: DAC found to be effective in terms of infection control and safety in our patient cohort and has been expanded for cementless 1-staged revisions in PJI of the hip in our institution.
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Antibacterianos/farmacología , Artroplastia de Reemplazo de Cadera/métodos , Materiales Biocompatibles Revestidos , Prótesis de Cadera , Infecciones Relacionadas con Prótesis/prevención & control , Humanos , Hidrogeles , Diseño de Prótesis , Reoperación , Estudios RetrospectivosRESUMEN
We describe a modified surgical technique developed to enhance the classical irrigation and debridement procedure to improve the possibilities of retaining an infected total knee arthroplasty. This technique, debridement antibiotic pearls and retention of the implant (DAPRI), aims to remove the intra-articular biofilm allowing a higher and prolonged local antibiotic concentration using calcium sulfate beads. The combination of three different surgical techniques (methylene blue staining, argon beam electrical stimulation, and chlorhexidine gluconate brushing) might enhance the identification, disruption, and finally removal of the bacterial biofilm, which is the main responsible of antibiotics and antibodies resistance. The DAPRI technique might represent a safe and more conservative treatment for acute and early hematogenous periprosthetic joint infection.
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Antibacterianos/uso terapéutico , Artritis Infecciosa/terapia , Artroplastia de Reemplazo de Rodilla/efectos adversos , Desbridamiento/métodos , Prótesis e Implantes/efectos adversos , Infecciones Relacionadas con Prótesis/terapia , Anciano , Anciano de 80 o más Años , Humanos , Masculino , Persona de Mediana Edad , Reoperación , Estudios Retrospectivos , Resultado del TratamientoAsunto(s)
Artritis Infecciosa/prevención & control , Artroplastia de Reemplazo , Infecciones Relacionadas con Prótesis/prevención & control , Animales , Profilaxis Antibiótica , Anticoagulantes/efectos adversos , Artritis Infecciosa/diagnóstico , Artritis Infecciosa/etiología , Traslocación Bacteriana , Suplementos Dietéticos , Endoscopía/efectos adversos , Fiebre , Humanos , Staphylococcus aureus Resistente a Meticilina , Infecciones Relacionadas con Prótesis/diagnóstico , Infecciones Relacionadas con Prótesis/etiologíaAsunto(s)
Artroplastia de Reemplazo/efectos adversos , Infecciones Relacionadas con Prótesis/prevención & control , Antibacterianos/administración & dosificación , Anticoagulantes/administración & dosificación , Prótesis de Cadera , Humanos , Infecciones Relacionadas con Prótesis/diagnóstico , Infecciones Relacionadas con Prótesis/etiología , Infección de la Herida Quirúrgica/diagnóstico , Infección de la Herida Quirúrgica/etiología , Infección de la Herida Quirúrgica/prevención & controlRESUMEN
Persistent osteomyelitis is a severe and challenging problem in bone surgery. We describe a surgical intervention in a young adult which combines a bone debridement process, a plastic muscle flap sealing and the administration of a novel bone substitution material with anti-infective properties. After 1 year, the patient showed no signs or symptoms of a reoccurrence of infection with full load capacity of the treated leg.