Spatiotemporal atmospheric in-situ carbon dioxide data over the Indian sites-data perspective.

In the current study, atmospheric carbon dioxide (CO2) data covering multiple locations in the Indian subcontinent are reported. This data was collected using a dedicated ground-based in-situ network established as part of the Geosphere-Biosphere Programme (CAP-IGBP) of the Climate and Atmospheric Processes of the Indian Space Research Organisation (ISRO). Data are collected over Ponmudi, Ooty, Sriharikota, Gadanki, Shadnagar, Nagpur, and Dehradun during 2014-2015, 2017-2020, 2012, 2011-2015, 2014-2017, 2017 and 2008-2011, respectively. The atmospheric CO2 generated as part of the CAP-IGBP network would enhance the understanding of CO2 variability in different time scales ranging from diurnal, seasonal, and annual over the Indian region. Data available under this network may be interesting to other research communities for modeling studies and spatiotemporal variability of atmospheric CO2 across the study locations. The work also evaluated the CO2 observations against the Model for Interdisciplinary Research on Climate version 4 atmospheric chemistry-transport model (MIROC4-ACTM) concentrations.

A validated chiral CE method for Frovatriptan, using cyclodextrin as chiral selector.

A cyclodextrin modified capillary zone electrophoretic method has been developed for the evaluation of chiral purity of Frovatriptan using sulfobutyl ether beta cyclodextrin (SB-beta-CD) as the chiral selector. The method is highly specific, accurate and reproducible. The method was optimized with a systematic method development approach by optimizing the pH of electrolyte, attempting the separation in different classes of chiral selectors and modifying parameters such as cyclodextrin concentration and the organic modifier type and concentration. The optimized method was validated for specificity, precision, linearity, accuracy and stability in solution using Imidazole as the internal standard. The limit of detection (LOD) and limit of quantification (LOQ) were 1.0 microg/mL and 5.0 microg/mL respectively for each isomer. The method was applied for estimating the chiral purity of various batches of Frovatriptan.