[Lynch syndrome (case report)].

The authors have analyzed the ethology, pathogenesis, treatment of Lynch Syndrome and described a case history of a 65-year-old woman with right breast cancer who was admitted into a hospital with intestines impassability and operation was performed. During the operation tumour, which caused the acute intestine impassability was identified. Apart from this, after the inner organ examination metastasis on stomach and tumour in upper and middle rectum were found. Histology and colonoscopy revealed the rectum adenocarcinoma (morphologic code 8140/3) with mild differentiation. Examination revealed adenocarcinoma with high and middle area differentiation (morphologic code 8480/3). Post-operational period was satisfactory. On the 10-th day the stitches were removed, chemical therapy was carried out according to the scheme set. Patient was examined after a year and two months. General health was satisfactory; she conducts an active life.

[Value of thrombolytic therapy in acute myocardial ischemia after administration of kinin system inhibitors]. / Znachenie tromboliticheskoi terapii pri ostroi ishemii miokarda na fone predvaritel'nogo vozdeistviia ingibitorov kininovoi sistemy.

An experimental study in dogs showed that thrombolytic revascularization after 4 to 6 hours of coronary arterial occlusion resulted in further deterioration of ischemia and an impairment of cardiac contractility and hemodynamics. Micromorphologically, multiple extravasations were demonstrated in the ischemized region in combination with insignificant glycogen content. The administration of thrombolytics was accompanied by enhanced fibrinolytic activity, yet the activation of the first three phases of blood coagulation showed no decline. In a series with thrombolytic therapy preceded by contrykal and heparin infusions, micromorphology revealed no intramyocardial hemorrhages in the ischemized region. Active functional cells showed micro- and macrogranular glycogen that accumulated into clusters in myocardial fibres. The significant postrevascularization decline in ischemia was accompanied by improved myocardial contractility and cardiac hemodynamics in the presence of hypocoagulation and increased fibrinolytic activity.