The Effect of Temperament on Outcomes of Opioid and Non-Opioid Pediatric Dental Sedation.

Purpose: To assess oral sedation success using midazolam and hydroxyzine with and without meperidine, and to assess the relationship between child temperament and sedation outcomes. Methods: This study recruited children between the ages of 36 and 95 months who were randomly assigned to receive dental treatment with an oral sedation regimen of midazolam (0.5 mg/kg) and hydroxyzine (1.0 mg/kg) with or without meperidine (1.5 mg/kg). Data were collected from the treatment log and electronic health records. Parents completed the Child Behavior Questionnaire Short Form (CBQ-SF) to assess temperament. Results: The study included 37 participants. The overall treatment success rate was 54 percent. There were no significant differences in sedation outcome with age, sex, insurance status, sedation regimen, isolation method or duration of procedure. Children with high pre-operative Frankl behavioral ratings were more likely to have a successful sedation outcome (P <0.01). Children who displayed high soothability experienced higher rates of success (P =0.04), which was more pronounced in the non-opioid group (P <0.01). Conclusion: The study showed low rates of success for a relatively small sample size. There was no difference in sedation success between the opioid group and non-opioid group. However, pre-procedure behavior and temperament characteristic of sooth- ability may warrant more exploration as predictors of sedation success.

Clinical Comparison of Three Esthetic Full-Coverage Restorations in Primary Maxillary Incisors at 12 Months.

Purpose: The purpose of this study was to compare the 12-month clinical outcomes of primary maxillary incisors restored with composite strip crowns (CSCs), NuSmile preveneered stainless steel crowns (PVSSCs), and NuSmile zirconia crowns (ZCs). Methods: A total of 135 teeth in 49 two- to four-year-olds with early childhood caries were randomly assigned to crown groups. Demographic and tooth-related variables at baseline and 12 months were assessed by calibrated examiners. Fisher's exact or chi-square tests were used to test associations (P<0.05). Parental satisfaction of crown esthetics was evaluated by questionnaire. Results: Children were, on average, 3.4 years old, female (55 percent), and had a mean decayed, missing, and filled primary teeth (dmft) index score of 10.6. At 12 months, crown retention was significantly lower for CSCs versus PVSSCs or ZCs (79 percent, 100 percent, and 95 percent, respectively; P=0.002). Partial and complete loss of material was significantly higher in CSCs than PVSSCs or ZCs (29 percent, 11 percent, and zero percent, respectively; P<0.001). CSCs presented with increased marginal discrepancies and color change (P<0.001). Most parents were very satisfied (87 percent); those dissatisfied were concerned with the color of CSCs and PVSSCs (63 percent versus 37 percent; P=0.005). Conclusions: Composite strip crowns showed significantly reduced clinical success in retention, durability, marginal adaptation, and color compared to preveneered stainless steel crowns or zirconia crowns. Parental esthetic satisfaction was highest for NuSmile ZCs.

Survival of Zirconia Crowns in Primary Maxillary Incisors at 12-, 24- and 36-Month Follow-Up.

Purpose: The purpose of this study was to assess the survival probability of zirconia crowns (ZCs) on primary maxillary incisors placed in children diagnosed with severe early childhood caries at 12-, 24-, and 36-month follow-up visits in a university pediatric dental clinic. Methods: Ninety-four teeth in 30 healthy 24- to 60-month-olds who received ZCs under general anesthesia participated in this study (N equals 94). Data included children's demographics, dental-related variables, appointment dates, survival of crown, and type of failure (defined as replacement of lost ZCs or extraction of the treated tooth due to evidence of apical periodontitis prior to natural exfoliation). Descriptive statistics were performed to examine demographics, while Kaplan-Meier survival curves were used to estimate survival probabilities of ZCs over time. Unadjusted and adjusted hazard ratios (HR) from Cox proportional hazard regression with robust standard errors were used to compare risk of ZC failure by patient and tooth characteristics. Results: The overall survival probabilities for ZCs at 12, 24, and 36 months were 93 percent, 85 percent, and 76 percent, respectively. Conclusion: With esthetic characteristics and high survival probabilities, zirconia crowns present as a suitable alternative for reconstruction of primary maxillary incisors in young children. (Pediatr Dent 2019;41(5):385-90).

Uso de bevacizumab (avastin) sublesional en papilomatosis laríngea recurrente / Sublesional use of bevacizumab (avastin) in recurrent laryngeal papillomatosis

La papilomatosis laríngea recurrente es una enfermedad producida por el virus del papiloma humano, que produce lesiones epiteliales exofíticas. En la actualidad, no existe un tratamiento definitivo, existiendo una gran recurrencia de las lesiones. Una de las alternativas promisorias es el uso de láser KTP con bevacizumab. No obstante, en nuestro medio, los hospitales no cuentan con láser KTP, utilizándose únicamente técnica en frío. Se presenta un caso clínico de papilomatosis laríngea recurrente con el uso de bevacizumab (avastin) a 16,5 mg/mL como terapia adyuvante a cirugía con técnica en frío.

Recurrent laryngeal papillomatosis is a disease caused by the human papillomavirus that causes exophytic epithelial lesions. Currently, there is no definitive treatment, existing high recurrence of lesions. One of the promising alternatives is the use of KTP laser with bevacizumab. However, in our hospitals we do not have KTP, but only cold excision. We present a case of recurrent laryngeal papillomatosis treated with intralesional injections of bevacizumab (avastin) 16.5 mg/mL as adjuvant therapy to cold excision.