Asunto(s)
Acné Vulgar , Medicamentos sin Prescripción , Humanos , Acné Vulgar/tratamiento farmacológico , Acné Vulgar/inmunología , Medicamentos sin Prescripción/uso terapéutico , Medicamentos sin Prescripción/efectos adversos , Mercadotecnía , Fármacos Dermatológicos/uso terapéutico , Alérgenos/inmunología , Alérgenos/efectos adversos , Hipersensibilidad a las Drogas/inmunología , Hipersensibilidad a las Drogas/diagnósticoAsunto(s)
Toxinas Botulínicas Tipo A/uso terapéutico , Carcinoma de Células Escamosas/cirugía , Mejilla/cirugía , Fístula/tratamiento farmacológico , Enfermedades de las Parótidas/tratamiento farmacológico , Complicaciones Posoperatorias/tratamiento farmacológico , Neoplasias Cutáneas/cirugía , Anciano de 80 o más Años , Carcinoma de Células Escamosas/patología , Humanos , Masculino , Cirugía de Mohs , Estadificación de Neoplasias , Fármacos Neuromusculares/uso terapéutico , Neoplasias Cutáneas/patologíaRESUMEN
The tethering together of sister chromatids by the cohesin complex ensures their accurate alignment and segregation during cell division. In vertebrates, sister chromatid cohesion requires the activity of the ESCO2 acetyltransferase, which modifies the Smc3 subunit of cohesin. It was shown recently that ESCO2 promotes cohesion through interaction with the MCM replicative helicase. However, ESCO2 does not significantly colocalize with the MCM complex, suggesting there are additional interactions important for ESCO2 function. Here we show that ESCO2 is recruited to replication factories, sites of DNA replication, through interaction with PCNA. We show that ESCO2 contains multiple PCNA-interaction motifs in its N terminus, each of which is essential to its ability to establish cohesion. We propose that multiple PCNA-interaction motifs embedded in a largely flexible and disordered region of the protein underlie the unique ability of ESCO2 to establish cohesion between sister chromatids precisely as they are born during DNA replication.
