RESUMEN
Two 1,2,3,4-tetrahydoquinoline-based compounds were synthesized and evaluated for antinociceptive properties. Both compounds displayed no significant analgesic activity and at the higher dose showed no characterized CNS depressant activity.
Asunto(s)
Analgésicos/síntesis química , Analgésicos/farmacología , Quinolinas/síntesis química , Quinolinas/farmacología , Analgésicos/química , Animales , Espectroscopía de Resonancia Magnética , Antagonistas del Receptor de Neuroquinina-1 , Quinolinas/química , RatasRESUMEN
A series of 3-methoxypyrazole derivatives was synthesized and tested as antifungal agents. The substituents were chosen on the base of their lipophylicity and for their presence in well-known antifungal drugs. The compounds displayed no significant activity in vitro.
Asunto(s)
Antifúngicos/síntesis química , Hongos/efectos de los fármacos , Antifúngicos/química , Antifúngicos/farmacología , Fenómenos Químicos , Química Física , Cromatografía en Capa Delgada , Espectroscopía de Resonancia Magnética , Pruebas de Sensibilidad MicrobianaRESUMEN
Some quinoline-based mono- and dicarboxylic acids structurally related to kynurenic acid have been synthesized and screened as antagonists of neurotransmission of NMDA, AMPA and KA excitatory amino acid receptors. Higher affinity for NMDA receptor was pointed out in the short series, but all the compounds, even those with key structural features of glutamic acid showed no significant activity.
Asunto(s)
Ácidos Carboxílicos/síntesis química , Ácidos Dicarboxílicos/síntesis química , Quinolinas/síntesis química , Receptores de Aminoácidos/antagonistas & inhibidores , Ácidos Carboxílicos/farmacología , Ácidos Dicarboxílicos/farmacología , Espectroscopía de Resonancia Magnética , Quinolinas/farmacología , Receptores AMPA/antagonistas & inhibidores , Receptores de Ácido Kaínico/antagonistas & inhibidores , Receptores de N-Metil-D-Aspartato/antagonistas & inhibidores , Transmisión Sináptica/efectos de los fármacosRESUMEN
A short series of di-functionalized benzodifurans and phenanthrolines were synthesized for in vitro antimicrobial activity. Dicarboxaldehydes, chiefly those with a phenanthroline supporting moiety, proved to be most effective, showing significant fungal growth inhibition.
Asunto(s)
Antibacterianos/síntesis química , Benzofuranos/síntesis química , Fenantrolinas/síntesis química , Bacterias/efectos de los fármacos , Benzofuranos/farmacología , Fenómenos Químicos , Química , Pruebas de Sensibilidad Microbiana , Fenantrolinas/farmacologíaRESUMEN
A short series of N-monosubstituted (aryl, aminoacyl, dipeptidyl)-2-(2-aminothiazol-4-yl)-(Z) -2-methoxyiminoacetamides was synthesized and tested for antimicrobial activity. A few members showed a somewhat interesting inhibitory action against Cryptococcus neoformans (MIC = 150 micrograms/ml).
Asunto(s)
Acetamidas/síntesis química , Antiinfecciosos/síntesis química , Tiazoles/síntesis química , Acetamidas/farmacología , Antibacterianos , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Fenómenos Químicos , Química , Hongos/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Tiazoles/farmacologíaAsunto(s)
Antiinflamatorios no Esteroideos/síntesis química , Cobre/síntesis química , Tioglucósidos/síntesis química , Tioglicósidos/síntesis química , Animales , Antiinflamatorios no Esteroideos/efectos adversos , Antiinflamatorios no Esteroideos/farmacología , Fenómenos Químicos , Química , Cobre/efectos adversos , Cobre/farmacología , Masculino , Ratas , Ratas Endogámicas , Tioglucósidos/efectos adversos , Tioglucósidos/farmacologíaRESUMEN
Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
Asunto(s)
Antifúngicos/síntesis química , Bencimidazoles/síntesis química , Compuestos de Bencilo/síntesis química , Indoles/síntesis química , Bencimidazoles/farmacología , Compuestos de Bencilo/farmacología , Candida/efectos de los fármacos , Fenómenos Químicos , Química , Indoles/farmacología , Pruebas de Sensibilidad MicrobianaRESUMEN
A series of 1,2,3,4-tetrahydroquinolines and of 1,2,3,4-tetrahydroisoquinolines were synthesised and evaluated for analgesic activity by both hot-plate and acetic acid writhing methods in rats. Te most potent compound was 2-methyl-1,2,3,4-tetrahydro-5-quinolinol (IV i) which was shown to be 1/8 and 1/50 as active as morphine according to the employed assay. The analgesic activity was shown to be associated to a not selective action on the CNS.
Asunto(s)
Analgésicos/síntesis química , Isoquinolinas/síntesis química , Quinolinas/síntesis química , Analgésicos/farmacología , Analgésicos/toxicidad , Animales , Fenómenos Químicos , Química , Isoquinolinas/farmacología , Isoquinolinas/toxicidad , Masculino , Ratones , Quinolinas/farmacología , Quinolinas/toxicidad , RatasRESUMEN
1-(Naphtho[1,2-b]furan-2-yl)-2-(isopropylamino)ethanol (II) and 1-(naphtho[2,3-b]furan-2-yl)-2-(isopropylamino)ethanol (III) show low beta-adrenergic blocking activity and unlike the naphtho [2,1-b]furan derivatives (1,2) do not appear to give rise to metabolites with high beta-adrenoceptor inhibitory properties. The inclusion of the --OCH2-- moiety in an aromatic nucleus larger than the benzofuran system (bufuralol, Ro 3-3528) caused loss of the biological activity.
Asunto(s)
Antagonistas Adrenérgicos beta/síntesis química , Furanos/síntesis química , Animales , Presión Sanguínea/efectos de los fármacos , Fenómenos Químicos , Química , Furanos/farmacología , Cobayas , Técnicas In Vitro , Masculino , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Ratas , Ratas EndogámicasRESUMEN
Some derivatives of N'-(5-nitro-2-furoyl)-N2-(3-chloro-1H-indenyl-2-methylene)hydrazine (I) were synthesized and screened for in vitro antimicrobial activity. None was more active than the parent compound and the greater hydrophilic character was associated with loss of inhibitory activity against gram-negative bacteria.
Asunto(s)
Antibacterianos/síntesis química , Hidrazinas/síntesis química , Bacterias/efectos de los fármacos , Fenómenos Químicos , Química , Hidrazinas/farmacología , IndenosRESUMEN
Some formylthioester and formylester amidinohydrazones with aromatic N-heterocyclic moieties, were synthesized and screened in vitro against the MP mutant of herpes simplex virus type 1 [HSV-1 (MP)] and parainfluenza type 3 virus, HA-1/CR-8 strain. The amidinohydrazone of 1-phenyl-4-formyl-3-(ethylthio)carbonylpyrrole (I) was the most active compound.
Asunto(s)
Antivirales/síntesis química , Hidrazonas/síntesis química , Hidrazonas/farmacología , Indoles/síntesis química , Indoles/farmacología , Virus de la Parainfluenza 3 Humana/efectos de los fármacos , Pirroles/síntesis química , Pirroles/farmacología , Quinolinas/síntesis química , Quinolinas/farmacología , Simplexvirus/efectos de los fármacosRESUMEN
Some bis-amidinohydrazones of N-heterocyclic aromatic dialdehydes were synthesised and tested in vitro against the MP mutant of the herpes simplex virus type 1 [HSV - I (MP)]. Of the compounds tested, only those with and indole substrate showed some measure of biological activity.