Evaluation of the masticatory biomechanical function in Down syndrome and its Influence on sleep disorders, body adiposity and salivary parameters.

OBJECTIVE: To evaluate the phenotypic features of the masticatory biomechanics in atypical subjects with Down syndrome (DS). Its influence was analysed on sleep disorders, body adiposity and its risks, and some physicochemical properties of saliva. METHODS: Seventy subjects were enrolled to assess masticatory biomechanical function and divided into two groups: DS and control groups. Electrical activities of the masseter and temporal muscles (at rest and in maximum voluntary clench-MVC), maximum bite force-MBF and maximum mouth opening-MMO were investigated. Among the atypical subjects, just 24 participants underwent the anthropometry, the polysomnography II and the saliva testing (salivary flow rate-SFR, buffer capacity-BC and salivary cortisol levels, morning/SC-AM and night/SC-PM). RESULTS: MVC and MBF values showed high statistical significance in the control group (P < .001) than in the DS group of 35. MMO values were slightly increased in the DS group in relation to the control group. Overweight and obesity were found in both genders. Atypical women showed higher risk to develop cardiovascular-metabolic diseases than in atypical men. OSA severe was 20% for atypical women and 42.8% for atypical men, whereas snoring index was present in all genders. SFR was reduced in 100% of atypical subjects (hyposalivation in 10% women and 28.5% men). Furthermore, 100% BC, 66.6% SC-AM and 91.6% SC-PM showed normal patterns. CONCLUSION: Masseter and temporal muscle hypotonia was found in all atypical subjects with DS. This muscle dysfunction strongly was related to overweight/obesity, risks for development of cardiovascular/metabolic diseases, OSA severity, successive snoring episodes and salivary flow reduction in DS.

Interdisciplinary approach to trating patients with epithelioid angiosarcoma: a case report / Conduta interdisciplinar para tratar paciente com angiossarcoma epitelióide: relato de um caso-clínico

Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. The present study aims to describe the radiological, clinicopathological, and immunohistochemical findings of a case of epithelioid angiosarcoma located in the posterior mediastinum of a 65-year-old male patient who underwent surgery and clinical treatment (Doxorubicin-based chemoterapy). It could be observed that the patient presented poor oral hygiene, severe cervical erosions in his teeth, chronic caries, periodontal disease, and periapical abscess. For this reason, the participation of a dentist in an interdisciplinary team is of utmost importance. Oral support treatment also becomes essential in an attempt to eliminate all foci of oral infections, as well as minimize morbidity and improve the general condition of the patient before, during, and after oncological treatment. In addition, the dentist will work toward the education and motivation of the patient to take on an appropriate oral hygiene so as to minimize the oral complications of chemotherapy, in turn providing better conditions for the patient to eat, speak, socialize, and maintain a high quality of life.

Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits.

This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (D-PTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.

Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes.

This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.

Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits

This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (D-PTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.

Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes

This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10 percent formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.

Regeneração óssea cranioplastia e complicações em clínicas coelhos com diabetes induzida por aloxana

ESTA pesquisa avaliou o Processo de Reparação óssea Defeitos cirúrgicos criados em hum dos Ossos parietal de coelhos diabéticos Utilizando a técnica de Regeneração óssea Guiada Parágrafo se observar OS Efeitos do nd aloxano Indução do diabetes mellitus. Vinte e quatro coelhos Adultos Foram divididos em Três Grupos de estudo: Controle (C), diabético (D ) e diabético Associada à politetrafluoretileno expandido (PTFE) de membrana (D- PTFE). Para Indução do diabetes , OS Uma animais receberam dose de aloxano monohidratado (90 mg / kg ) por via intravenosa OU NA auricular veia femoral. No grupo D , a membrana de PTFE coberto Ambos , Assoalho e nd Superfície do Defeito ósseo. Nos Grupos C e D, o Defeito ósseo preenchido com coágulo sangüíneo foi. Os espécimes fixados em formol Foram 10 Por Cento e Preparados Para análise histomorfométrica . Os resultados Mostraram Que hum 90 mg / kg dose de aloxano monohidratado promover Foi Suficiente Para de diabetes mellitus , Quando administrado na Veia auricular. Regeneração óssea Foi menor Não grupo diabético comparado com QUANDO OS Grupos controle e diabético PTFE, Mas não houve Diferença estatisticamente significante Entre os Dois Grupos experimentais (D e D- PTFE). Como complicações oral e clínica geral Entre os diabéticos Foram Perda de peso , poliúria , polifagia e gengivite crônica da sepultura do IPT (AU)

Homogenous demineralized dentin matrix for application in cranioplasty of rabbits with alloxan-induced diabetes: histomorphometric analysis.

PURPOSE: The aim of this work was to evaluate the bone-repair process after implantation of homogenous demineralized dentin matrix (HDDM) slices in surgical defects created in the parietal bones of rabbits with alloxan-induced diabetes. MATERIALS AND METHODS: Forty-eight rabbits were selected and divided into 4 groups of 12 rabbits: the control group, diabetic rabbits (D), diabetic rabbits with a PTFE barrier (D-PTFE), and diabetic rabbits with a PTFE barrier and with slices of homogenous demineralized dentin matrix (D-PTFE+HDDM). The diabetic animals received a single dose of alloxan monohydrate (90 mg/kg) intravenously on the marginal ear vein, and their blood glucose was verified daily. The rabbits were sacrificed after 15, 30, 60, and 90 days. The histologic findings show both better bone structure and significantly greater bone density, as determined by histomorphometric analysis, for the D-PTFE + HDDM group than for the other 3 groups (P < .01). It was also observed that the mean bone density increased gradually from 15 to 90 days (except in the D-PTFE group). CONCLUSION: It was concluded that the HDDM was biocompatible with the bone repair of diabetic rabbits and that HDDM slices stimulated bone tissue formation. Facilitation of bone repair with HDDM could be useful in diabetic patients.

Densitometric analysis of the autogenous demineralized dentin matrix on the dental socket wound healing process in humans

The aim of this study was to evaluate the effects of the autogenous demineralized dentin matrix (ADDM) on the third molar socket wound healing process in humans, using the guided bone regeneration technique and a polytetrafluoroethylene barrier (PTFE). Twenty-seven dental sockets were divided into three groups: dental socket (Control), dental socket with PTFE barrier (PTFE), and dental socket with ADDM slices associated to PTFE barrier (ADDM + PTFE). The dental sockets were submitted to radiographic bone densitometry analysis and statistical analysis on the 15th, 30th, 60th and 90th days using analysis of variance (ANOVA) and Tukey's test (p £ 0.05). The radiographic analysis of the ADDM + PTFE group showed greater homogeneity of bone radiopacity than the Control group and the PTFE group, during all the observation times. The dentin matrix gradually disappeared from the dental socket during the course of the repair process, suggesting its resorption during the bone remodeling process. It was concluded that the radiographic bone density of the dental sockets treated with ADDM was similar to that of the surrounding normal bone on the 90th day. The ADDM was biocompatible with the bone tissue of the surgical wounds of human dental sockets. The radiographic analysis revealed that the repair process was discreetly faster in the ADDM + PTFE group than in the Control and PTFE groups, although the difference was not statistically significant. In addition, the radiographic image of the ADDM + PTFE group suggested that its bone architecture was better than that of the Control and PFTE groups.

O objetivo desta pesquisa foi avaliar a reparação óssea em alvéolos dentários após exodontia dos terceiros molares inferiores em humanos, com implantação de matriz dentinária desmineralizada autógena (MDDA) na cavidade e cobertura desta com barreira de politetrafluoretileno (PTFE). Foram selecionados 27 dentes, os quais foram divididos em três grupos: alvéolo dentário (Controle), alvéolo dentário com barreira de PTFE (PTFE) e alvéolo dentário com fatias de MDDA associada à barreira de PTFE (MDDA + PTFE). O alvéolo dentário foi submetido à análise de densitometria radiográfica e à análise estatística no 15°, 30°, 60° e 90° dias, utilizando-se a análise de variância (ANOVA) e teste de Tukey (p < 0,05). A análise radiográfica do grupo MDDA + PTFE mostrou maior homogeneidade na radiopacidade do trabeculado ósseo do que no grupo controle e grupo PTFE, durante todos os períodos de observação. A matriz dentinária foi desaparecendo do alvéolo dentário durante a evolução do processo de reparo, sugerindo sua reabsorção durante o processo de remodelação óssea. Concluiu-se que a densidade óssea radiográfica do alvéolo dentário tratado com MDDA foi similar à do osso normal circunjacente no 90° dia. A MDDA foi biocompatível com o tecido ósseo, quando implantada nos alvéolos dentários cruentos de humanos. Na análise radiográfica, pode-se verificar que o processo de reparo foi discretamente mais rápido no grupo MDDA + PTFE do que no grupo Controle e no grupo PTFE, porém não houve diferença estatística significante. Além disso, a imagem radiográfica sugeriu que a arquitetura óssea do grupo MDDA + PTFE foi melhor do que a arquitetura óssea do grupo controle e grupo PTFE.

Familial malignant osteopetrosis in children: a case report.

The clinical, radiological, pathological and laboratory findings of two brothers with autosomal recessive malignant osteopetrosis are presented. Our findings are similar to characteristics previously reported in the literature about patients with osteopetrosis. The 6-year-old male patient was pale and had petechiae on his arms and legs. He also had macrocephalia, splenomegaly, severe pancytopenia, genu valgus, hypocalcemia, amaurosis, cessation of physical development, generalized bone sclerosis and recurrent infections with a history of multiple incidences of acute otitis media. Generalized bone sclerosis and irregular sclerosis of the maxilla and mandible were seen on radiographs. The oral mucosa was apparently normal but permanent tooth eruption was delayed although there was early loss of deciduous teeth. The recommended treatment was blood transfusion and therapy with antibiotics when necessary; a bone marrow transplant was not possible due to lack of a compatible donor.

Densitometric analysis of the autogenous demineralized dentin matrix on the dental socket wound healing process in humans.

The aim of this study was to evaluate the effects of the autogenous demineralized dentin matrix (ADDM) on the third molar socket wound healing process in humans, using the guided bone regeneration technique and a polytetrafluoroethylene barrier (PTFE). Twenty-seven dental sockets were divided into three groups: dental socket (Control), dental socket with PTFE barrier (PTFE), and dental socket with ADDM slices associated to PTFE barrier (ADDM + PTFE). The dental sockets were submitted to radiographic bone densitometry analysis and statistical analysis on the 15th, 30th, 60th and 90th days using analysis of variance (ANOVA) and Tukey's test (p < or = 0.05). The radiographic analysis of the ADDM + PTFE group showed greater homogeneity of bone radiopacity than the Control group and the PTFE group, during all the observation times. The dentin matrix gradually disappeared from the dental socket during the course of the repair process, suggesting its resorption during the bone remodeling process. It was concluded that the radiographic bone density of the dental sockets treated with ADDM was similar to that of the surrounding normal bone on the 90th day. The ADDM was biocompatible with the bone tissue of the surgical wounds of human dental sockets. The radiographic analysis revealed that the repair process was discreetly faster in the ADDM + PTFE group than in the Control and PTFE groups, although the difference was not statistically significant. In addition, the radiographic image of the ADDM + PTFE group suggested that its bone architecture was better than that of the Control and PFTE groups.