Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System.

Divided and subtracted MRI is a novel imaging processing technique, where the difference of two images is divided by their sum. When the sequence parameters are chosen properly, this results in images with a high T1 or T2 weighting over a small range of tissues with specific T1 and T2 values. In the T1 domain, we describe the implementation of the divided Subtracted Inversion Recovery Sequence (dSIR), which is used to image very small changes in T1 from normal in white matter. dSIR has shown widespread changes in otherwise normal-appearing white matter in patients suffering from mild traumatic brain injury (mTBI), substance abuse, and ischemic leukoencephalopathy. It can also be targeted to measure small changes in T1 from normal in other tissues. In the T2 domain, we describe the divided echo subtraction (dES) sequence that is used to image musculoskeletal tissues with a very short T2*. These tissues include fascia, tendons, and aponeuroses. In this manuscript, we explain how this contrast is generated, review how these techniques are used in our research, and discuss the current challenges and limitations of this technique.

Diagnosis of Delayed Post-Hypoxic Leukoencephalopathy (Grinker's Myelinopathy) with MRI Using Divided Subtracted Inversion Recovery (dSIR) Sequences: Time for Reappraisal of the Syndrome?

Background: Delayed Post-Hypoxic Leukoencephalopathy (DPHL), or Grinker's myelinopathy, is a syndrome in which extensive changes are seen in the white matter of the cerebral hemispheres with MRI weeks or months after a hypoxic episode. T2-weighted spin echo (T2-wSE) and/or T2-Fluid Attenuated Inversion Recovery (T2-FLAIR) images classically show diffuse hyperintensities in white matter which are thought to be near pathognomonic of the condition. The clinical features include Parkinsonism and akinetic mutism. DPHL is generally regarded as a rare condition. Methods and Results: Two cases of DPHL imaged with MRI nine months and two years after probable hypoxic episodes are described. No abnormalities were seen on the T2-FLAIR images with MRI, but very extensive changes were seen in the white matter of the cerebral and cerebellar hemisphere on divided Subtraction Inversion Recovery (dSIR) images. dSIR sequences may produce ten times the contrast of conventional inversion recovery (IR) sequences from small changes in T1. The clinical findings in both cases were of cognitive impairment without Parkinsonism or akinetic mutism. Conclusion: The classic features of DPHL may only represent the severe end of a spectrum of diseases in white matter following global hypoxic injury to the brain. The condition may be much more common than is generally thought but may not be recognized using conventional clinical and MRI criteria for diagnosis. Reappraisal of the syndrome of DPHL to include clinically less severe cases and to encompass recent advances in MRI is advocated.

A study of new labor market entrants' job satisfaction trajectories during a series of consecutive job changes.

Previous research on the psychological effect of job change has revealed a honeymoon-hangover pattern during the turnover process. However, there is a dearth of evidence on how individuals react and adapt to multiple job changes over their working lives. This study distinguishes adaptation to a single job change in the short term from adaptation to the process of job change in the long term. Drawing on two large-scale, long-running panel data sets from Britain and Australia, it examined how job satisfaction trajectory evolved as individuals made a series of consecutive job changes since they first entered the labor market. Our fixed effect analyses show that in both countries, individuals experienced a stronger honeymoon effect with each successive job change, before gradually reverting to their baseline job satisfaction. In short, the amplitude of the honeymoon-hangover effect increased across multiple job changes. By distinguishing "adaptation to change" from "change in adaptation," this study generates original insights into the role of job mobility in facilitating career development and extends set point theory from understanding the impact of single life events to recurring life events. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Job insecurity, employability, and mental health in the new era: A test of plausible influence mechanisms and temporal effects.

Although job insecurity and employability have drawn much research attention, the plausible relationships between them and how they jointly influence mental health remain unclear in the literature. We draw upon JD-R and COR theories to test and contrast three plausible relationships between job insecurity and employability, using a longitudinal sample of 1216 employees over 18 years. We further expand tests of these theoretical positions by considering temporal dynamics, using dynamic structural equation models (DSEMs) for stronger mediation evidence and latent growth models (LGMs) to compare the effects of job insecurity and employability trends in predicting the trend of mental health. In general, findings showed that job insecurity mediated the relationship between employability and mental health, supporting the mediation hypothesis. We also found that employability moderated the relationship between job insecurity and mental health, supporting the moderation hypothesis, although the effect was weak. Results further suggested that the effect magnitudes of job insecurity and employability predicting mental health were significantly different. Specifically, job insecurity was a stronger predictor of mental health than employability across all 18 years; the trend of job insecurity also predicted the trend of mental health more strongly than the trend of employability. Taken together, this study not only advances theory precision but also methodological soundness of research on job insecurity, employability, and mental health, supporting the value of considering temporal factors in examining mental health effects of job insecurity and employability.

Safety behaviors and job satisfaction during the pandemic: The mediating roles of uncertainty and managerial commitment.

INTRODUCTION: As the Covid-19 pandemic affects the world, disruptions to work routines impose a psychological burden on people, and thus can affect their job performance and well-being. We conducted an empirical study to explore the links between the experience of Covid-19 and workers' safety behaviors and well-being outcome of job satisfaction. METHOD: Structural equation modelling (SEM) with a sample of 515 safety workers was conducted to simultaneously test the links among these constructs. RESULTS: Experience of Covid-19 was associated with lower employee job satisfaction, explained by higher psychological uncertainty and decreased perception of managerial commitment to safety. Notably, contrasting pathways from experience of Covid-19 to safety behaviors were found. On the one hand, higher psychological uncertainty caused by the pandemic was associated with lower perceptions of managerial safety commitment; and lower perceived managerial safety commitment was linked to reduced safety compliance and safety participation. On the other hand, experience of Covid-19 in this study showed unexpected positive direct links with safety behaviors, which might be explained by workers' enhanced safety knowledge, motivation, and status of mindfulness due to Covid-19 related safety instructions and communications. CONCLUSIONS: This exploratory study helps to deepen the understanding of workplace safety and well-being in the context of pandemic and in times of uncertainty. PRACTICAL APPLICATIONS: The practical insights are useful for applying appropriate strategies for managing the Covid-19 crisis, coping with uncertainties, and building a healthier and safer workplace in the long run.

Understanding and shaping the future of work with self-determination theory.

Self-determination theory has shaped our understanding of what optimizes worker motivation by providing insights into how work context influences basic psychological needs for competence, autonomy and relatedness. As technological innovations change the nature of work, self-determination theory can provide insight into how the resulting uncertainty and interdependence might influence worker motivation, performance and well-being. In this Review, we summarize what self-determination theory has brought to the domain of work and how it is helping researchers and practitioners to shape the future of work. We consider how the experiences of job candidates are influenced by the new technologies used to assess and select them, and how self-determination theory can help to improve candidate attitudes and performance during selection assessments. We also discuss how technology transforms the design of work and its impact on worker motivation. We then describe three cases where technology is affecting work design and examine how this might influence needs satisfaction and motivation: remote work, virtual teamwork and algorithmic management. An understanding of how future work is likely to influence the satisfaction of the psychological needs of workers and how future work can be designed to satisfy such needs is of the utmost importance to worker performance and well-being.

Understanding fatigue in a naval submarine: Applying biomathematical models and workload measurement in an intensive longitudinal design.

Fatigue is a critically important aspect of crew endurance in submarine operations, with continuously high fatigue being associated with increased risk of human error and long-term negative health ramifications. Submarines pose several unique challenges to fatigue mitigation, including requirements for continuous manning for long durations, a lack of access to critical environmental zeitgebers (stimuli pertinent to circadian physiology; e.g., natural sunlight), and work, rest and sleep occurring within an encapsulated environment. In this paper, we examine the factors that underlie fatigue in such a context with the aim of evaluating the predictive utility of a biomathematical model (BMM) of fatigue. Three experience sampling studies were conducted with submarine crews using a participant-led measurement protocol that included assessments of subjective sleepiness, workload (NASA-Task Load Index [TLX] and a bespoke underload-overload scale), and sleep. As expected, results indicated that predicting KSS with a BMM approach outperformed more conventional linear modelling approaches (e.g., time-of-day, sleep duration, time awake). Both the homeostatic and circadian components of the BMM were significantly associated with KSS and used as controls in the workload models. We found increased NASA-TLX workload was significantly associated with increased average KSS ratings at the between-person level. However, counter to expectations, the two workload measures were not found to have significant linear or quadratic relationship with fatigue at the within-person level. An important outcome of the research is that applied fatigue researchers should be extremely cautious applying conventional linear predictors when predicting fatigue. Practical implications for the submarine and related extreme work context are discussed. Important avenues for continued research are outlined, including directly estimating BMM parameters.

'I think they might just go to the doctor': qualitatively examining the (un)acceptability of newer HIV testing approaches among Vietnamese-born migrants in greater-Brisbane, Queensland, Australia.

Background In high-income countries (HICs), migrants often have higher rates of late diagnosis of HIV than the host population. Timely HIV testing has significant implications for HIV prevention and management. Newer HIV testing approaches, namely provider-initiated testing and counselling (PITC), HIV rapid testing (HIV RT) and HIV self-testing (HIV ST), aim to reach those populations most at risk and, particularly, those who have not previously tested for HIV. METHODS: This study used semi-structured interviews to examine the (un)acceptability, barriers and facilitators to newer HIV testing approaches (i.e. PITC, HIV RT and HIV ST) among Vietnamese-born migrants (n = 10) in greater-Brisbane, Queensland, Australia. RESULTS: Vietnamese-born migrants had mixed perspectives on the (un)acceptability of newer HIV testing approaches. PITC was largely viewed by participants as a facilitator to HIV testing for Vietnamese-born migrants. Likewise, HIV RT (undertaken by a doctor in a medical setting, as opposed to a trained community member in a community setting) was generally considered to facilitate HIV testing. HIV ST was largely not considered acceptable to Vietnamese-born migrants and they would prefer to go to a doctor for HIV testing. Several factors were identified that either facilitate or act as barriers to newer HIV testing approaches, including privacy; cost of (accessing) HIV testing; comfort and convenience; healthcare provider relationship; risk perception; symptoms; and technical and emotional support. CONCLUSIONS: There is a need to understand migrants' HIV testing preferences if poorer HIV-related outcomes are to be overcome. The findings from this study show a preference for doctor-centred HIV testing, due to enhanced privacy, accuracy and support.

Antecedents of safety behavior in construction: A literature review and an integrated conceptual framework.

There has been no scarcity in the literature of suggested antecedents of employee safety behavior, and this paper brings together the disaggregated antecedents of safety behavior in the construction field. In total, 101 eligible empirical articles are obtained. Bibliometric and context analyses are combined to identify the influential journals, scholars, keywords, use of theory, research methods, and countries or regions of the empirical samples. The 83 factors that are identified are divided into five groups, namely (a) individual characteristics, (b) workgroup interactions, (c) work and workplace design, (d) project management and organization, and (e) family, industry, and society. This indicates that the causes of safety behavior are manifold. Various factors from different systems likely work in concert to create situations in which an individual chooses to comply with safety rules and participate voluntarily in safety activities. Given this, we propose that safety behavior is only an ostensible symptom of more complex "The Self-Work-Home-Industry/Society" systems and establish a safety behavior antecedent analysis and classification model. Based on this model, we develop a resource flow model, illustrating why, how, and when the flow of resources between the five systems-namely the self system, work system, home system, work-home interface system, and industry/society system-either promotes or inhibits safety behavior. The safety behavior antecedent analysis and classification model and resource flow model are based mainly on bioecological system theory and resources theories. Avenues for future theoretical development and method designs are suggested based on the reviewed findings and the two conceptual models. The intention with this systematic review together with the two integrated conceptual models is to advance theoretical thinking on how safety behavior can be promoted, or instead, inhibited.

Human and organizational factors within the public sectors for the prevention and control of epidemic.

Pervasive human and organizational factors (HOFs) within the public sectors play a vital role in the prevention and control of epidemic (PCE). Insufficient analysis of HOFs has helped continue the use of flawed precautions. In this study, we attempted to establish a quantitative model to (a) clarify HOFs within the public sectors with regard to PCE, (b) predict the probability of relevant risk factors and an epidemic, and (c) diagnose the critical factors. First, we systematically identified 47 HOFs based on the Human Factors Analysis and Classification System (HFACS). We then converted the HFACS framework into a Bayesian Network (BN) after determining the causalities among these factors. Finally, we applied the hybrid HFACS-BN model to analyze the COVID-19 outbreak in China by virtue of its efficacy in probability prediction and diagnosis of key risk factors, and thus to test the feasibility of the model itself. This study contributes to a holistic analysis of HOFs within the public sectors with regard to PCE by providing a risk assessment model for epidemics or pandemics, and developing risk analysis methods for the public health field.

Safety stressors, safety-specific trust, and safety citizenship behavior: A contingency perspective.

Employee safety citizenship behavior (SCB) is critical for workplace safety in a high-risk work environment, but few studies have addressed how safety stressors affect SCB. This study investigates the different relationships between safety stressors (safety role ambiguity, safety role conflict, and interpersonal safety conflict) and two forms of SCB (proactive and prosocial). It also examines the moderating effect of safety-specific trust (cognition- and affect-based) within these relationships. An analysis of 332 multisource data from frontline workers and their safety supervisors in China reveals that safety role ambiguity and safety role conflict negatively affect proactive safety behaviors, while interpersonal safety conflict impedes prosocial safety behaviors. Additionally, cognition-based safety trust alleviates the effects of safety role ambiguity and safety role conflict on proactive safety behaviors, whereas affect-based safety trust effectively restricts the influence of interpersonal safety conflict on prosocial safety behaviors. These results suggest that managers need to instill SCB in their subordinates and combat stressful conditions through interventions that enhance safety-specific trust.

Evaluating the Outcomes for Bereaved People Supported by a Community-Based Suicide Bereavement Service.

Background: Postvention services aim to support people bereaved by suicide and reduce the adverse impacts associated with suicide bereavement. StandBy Support After Suicide is a community-based suicide bereavement service that provides support and a coordinated response for people bereaved by suicide. Aims: We aimed to evaluate the effectiveness of the StandBy service in reducing suicidality, grief reactions associated with suicide bereavement, and social isolation among clients. Method: A retrospective cross-sectional design using an online survey was used to compare StandBy clients with people bereaved by suicide who did not access the StandBy service. Results: Among people whose most recent loss to suicide was within the past 12 months, people supported by StandBy were significantly less likely to be at risk of suicidality, experience a loss of social support, and experience social loneliness compared with people bereaved by suicide who had not accessed the StandBy service. Limitations: Owing to the use of a cross-sectional design, it was not possible to determine changes over time. Conclusion: Postvention in the form of a community-based crisis intervention, at the time of or close to a suicide, is effective in reducing adverse outcomes associated with suicide bereavement, and an important aspect of suicide prevention.

Effects of chronic job insecurity on Big Five personality change.

Drawing on Cybernetic Big Five Theory, we propose that chronic job insecurity is associated with an increase in neuroticism and decreases in agreeableness and conscientiousness (the 3 traits that reflect stability). Data collected from 1,046 employees participating in the Household, Income and Labor Dynamics in Australia survey over a 9-year period were analyzed. Job insecurity and the other job-related variables (i.e., job control, time demand, and job stress) were measured in all years, and personality was measured at the first, fifth, and ninth years. We applied latent trait-state-occasion modeling and specified models using variables across two timeframes (from Time 1 to Time 4 and from Time 5 to Time 9). Results showed that chronic job insecurity over four or five preceding years predicted a small increase in neuroticism and a small decrease in agreeableness in both timeframes, and a small decrease in conscientiousness in the first timeframe. We also found that chronic job stress explained the association between chronic job insecurity and the increase in neuroticism, but not changes in other personality traits, in the first timeframe. Similar results were obtained when the entire 9-year timeframe was examined. The results generally showed null effects of chronic job insecurity with regard to extraversion and openness (the traits that reflect plasticity). This study suggests that job insecurity has important implications for one's personality when experienced over a long-term period. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Effectiveness of a locally produced ready-to-use supplementary food in preventing growth faltering for children under 2 years in Cambodia: a cluster randomised controlled trial.

This cluster randomised controlled trial tested the effectiveness of a locally produced, fish-based, ready-to-use supplementary food (RUSF) to prevent growth faltering (decline in z-scores). Cambodian infants (n= 485), aged 6 to 11 months, were randomised by site to receive the RUSF, Corn-Soy Blend++ (CSB++), micronutrient powders (MNP), or no supplement (control). The intervention was for 6 months. In unadjusted analysis, the control group had statistically significantly decreased weight-for-age z-scores (WAZ; -0.02, 95%CI = -0.03 - -0.01, P= 0.001) and height-for-age z-scores (HAZ; -0.07, 95%CI = -0.09 - -0.05, P < 0.001), and increased mid-upper arm-circumference (MUAC; 0.02cm, 95%CI = 0.01 - 0.04, P = 0.010), but no statistically significant change in weight-for-height z-scores (WHZ). The RUSF group did not differ significantly from the control for WAZ, HAZ or WHZ (in other words, WAZ and HAZ decreased and WHZ did not change), but had increased MUAC in comparison to the control (0.04cm, 95%CI = 0.01 - 0.06, P = 0.008). There were no statistically significant differences between the RUSF group and the CSB++ or MNP groups with respect to WAZ, HAZ, WHZ or MUAC. Interestingly, in adjusted analysis, low consumers of RUSF had increased WAZ, WHZ and MUAC (0.03, 95%CI = 0.01-0.06, P = 0.006; 0.04, 95%CI = 0.01-0.08, P = 0.026; and 0.05cm, 95%CI = 0.02-0.09, P = 0.004, respectively) compared with the control. The novel RUSF, particularly in small quantities, protected against ponderal growth faltering, but the improvements were of limited clinical significance.

WITHDRAWN: What does safety commitment mean to leaders? A multi-method investigation.

The Publisher regrets that this article is an accidental duplication of an article that has already been published in Journal of Safety Research, 68 (2019) 203-214, https://doi.org/10.1016/j.jsr.2018.12.011. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

Development and testing of locally-produced ready-to-use therapeutic and supplementary foods (RUTFs and RUSFs) in Cambodia: lessons learned.

BACKGROUND: Rates of childhood undernutrition are persistently high in Cambodia. Existing ready-to-use supplementary and therapeutic foods (RUSFs and RUTFs) have had limited acceptance and effectiveness. Therefore, our project developed and trialled a locally-produced, multiple micronutrient fortified lipid-based nutrient supplement (LNS) with therapeutic and supplementary versions. This ready-to-use food (RUF) is innovative in that, unlike many RUFs, it contains fish instead of milk. Development began in 2013 and the RUF was finalised in 2015. From 2015 until the present, both the RUTF and the RUSF versions were trialled for acceptability and effectiveness. METHODS: This paper draws on project implementation records and semi-structured interviews to describe the partnership between the Cambodian Ministries of Health and Agriculture, Forestry and Fisheries, UNICEF, the French National Research Institute for Sustainable Development (IRD), universities, and Vissot factory. It discusses the project implementation and lessons learned from the development and trialling process, and insights into positioning nutrition on the health agenda in low and middle-income countries. RESULTS: The lessons learned relate to the importance of project planning, management, and documentation in order to seize opportunities in the research, policy, advocacy, and programming environment while ensuring adequate day-to-day project administration and resourcing. CONCLUSIONS: We conclude that projects such as ours, that collaborate to develop and test novel, locally-produced RUTFs and RUSFs, offer an exciting opportunity to respond to both local programmatic and broader research needs.

Safety citizenship behavior (SCB) in the workplace: A stable construct? Analysis of psychometric invariance across four European countries.

Safety citizenship behaviors (SCBs) are important participative organizational behaviors that emerge in work-groups. SCBs create a work environment that supports individual and team safety, encourages a proactive management of workplace safety, and ultimately, prevents accidents. In spite of the importance of SCBs, little consensus exists on research issues like the dimensionality of safety citizenship, and if any superordinate factor level of safety citizenship should be conceptualized, and thus measured. The present study addressed this issue by examining the dimensionality of SCBs, as they relate to behaviors of helping, stewardship, civic virtue, whistleblowing, voice, and initiating change in current practices. Data on SCBs were collected from four industrial plants (N = 1065) in four European countries (Italy, Russia, Switzerland, United Kingdom). The results show that SCBs structure around two superordinate second-order factors that reflect affiliation and challenge. Multi-group analyses supported the structure and metric invariance of the two-factor model across the four national subsamples.

What does safety commitment mean to leaders? A multi-method investigation.

INTRODUCTION: Perceived management safety commitment as an aspect of safety climate or culture is a key influence on safety outcomes in organizations. What is unclear is how perceptions of management commitment are created by leaders. METHOD: To address this gap in the literature, we position safety commitment as a leadership construct viewed from the perspectives of the leaders who experience and demonstrate it. In this paper, an established multidimensional commitment framework is applied to leaders' safety commitment (consisting of affective, normative, and calculative commitment). Via an exploratory sequential mixed methods design combining interviews (n = 40) and surveys (n = 89), we investigate the applicability of this theoretical conceptualization to safety commitment. RESULTS: The results indicate the multiple dimensions captured leaders' safety commitment well, safety commitment can be demonstrated via a range of behaviors, and the dimensions' association with behavioral demonstrations aligned with those of other types of commitment reported in the literature. Only affective safety commitment was consistently associated with demonstrations of safety commitment. The link between high levels of affective and normative safety commitment and demonstrations was more pronounced when participants perceived their company's safety climate more positively. CONCLUSIONS: Adopting a focus on leaders' experience of safety commitment offers opportunities for new research into the way in which safety commitment perceptions are shaped by leaders. Practical application: The findings can support leaders' reflection about their personal mindset around safety and support them in fostering strong safety climates and cultures. It further encourages organizations in creating work environments that in particular foster affective and normative safety commitments in leaders.