RESUMEN
This document was produced with the support of the National Medical Association for the Study of Comorbidities (NASС). In 2021 the first multidisciplinary National Consensus on the pathophysiological and clinical aspects of Increased Epithelial Permeability Syndrome was published. The proposed guidelines are developed on the basis of this Consensus, by the same team of experts. Twenty-eight Practical Guidelines for Physicians statements were adopted by the Expert Council using the "delphic" method. Such main groups of epithelial protective drugs as proton pump inhibitors, bismuth drugs and probiotics are discussed in these Guidelines from the positions of evidence-based medicine. The clinical and pharmacological characteristics of such a universal epithelial protector as rebamipide, acting at the preepithelial, epithelial and subepithelial levels, throughout gastrointestinal tract, are presented in detail.
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Médicos , Inhibidores de la Bomba de Protones , Humanos , Inhibidores de la Bomba de Protones/uso terapéutico , Bismuto , Consenso , Medicina Basada en la EvidenciaRESUMEN
Aim To study the interrelationship between intensity of chronic systemic inflammation (CSI) with severity of the condition and intestinal microbiocenosis parameters in patients with chronic heart failure (CHF).Material and methods 47 hospitalized patients with symptomatic CHF were evaluated. The following parameters were determined: clinical condition; N-terminal pro-B-type natriuretic peptide (NT-proBNP). C-reactive protein (CRP); serum interleukins (IL) 6 and 10; and intestinal microbiocenosis composition by mass-spectrometry of microbial markers in whole blood. Microbiocenosis indexes were compared in the main group and in 38 outpatient patients with arterial hypertension and ischemic heart disease without CHF.Results Direct, medium-power correlations were found between CRP and IL-6 concentrations and severity of clinical condition (NT-proBNP, ХСРstage, and edema severity) in patients with CHF. Most patients with CHF had lower numbers of bifido-, lacto-, propionic-, and eubacteria, and Clostridium (С.) ramosum and higher numbers of aspergillus. Among CHF patients, the highest indexes of endotoxemia, gram (-) bacteria, cocci, actinomycetes, and microfungi were observed in the group with NT-proBNP from 400 to 2000âpg/ml. Direct correlations were observed for amounts of C. hystolyticum, Pseudonocardia spp., and Aspergillus spp. with IL-6 and IL-10 and unidirectional inverse correlation were observed for these cytokines with Propionibacterium acnes and jensenii, Streptomyces spp., and Nocardia asteroides. In addition, IL-6 concentration was negatively correlated with contents of Staphylococcus aureus, C. difficile, C. ramosum, Eggerthella lenta, and Corynebacterium spp. and was positively correlated with C. propionicum, Moraxella spp. and Flavobacterium spp. Concentration of IL-6 directly correlated with the number of Eubacterium spp. and inversely correlated with numbers of Ruminicoccus spp. and Streptomyces farmamarensis. The amount of Streptomyces farmamarensis negatively correlated with CRP concentrations.Conclusion The study results evidence the significance of intestinal microbial-tissue complex in the pathogenesis of CSI in CHF and allow suggesting this complex as a promising target for therapy.
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Microbioma Gastrointestinal , Insuficiencia Cardíaca , Biomarcadores , Enfermedad Crónica , Clostridioides difficile , Humanos , Inflamación , Péptido Natriurético Encefálico , Fragmentos de PéptidosRESUMEN
We studied the levels endotoxin and microbial markers in the blood of female rats with experimental heart failure and the effects of preliminary treatment with a prebiotic complex based on fermented wheat bran and inactivated Saccharomyces cerevisiae culture on these parameters. The concentrations of endotoxin, markers of lactobacilli, and opportunistic microorganisms were found to increase in rats with experimental heart failure and significantly decreased against the background of treatment with prebiotic complex. The dynamics of markers of bifidobacteria, eubacteria, and propionibacteria were reciprocal. The observed effect of the prebiotic complex effect on gut microbiota in rats with experimental heart failure suggests that this complex can be used for the correction of intestinal dysbiosis and endotoxemia in this clinical condition.
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Disbiosis/dietoterapia , Endotoxemia/dietoterapia , Insuficiencia Cardíaca/dietoterapia , Prebióticos/administración & dosificación , Animales , Animales no Consanguíneos , Bacterias/crecimiento & desarrollo , Bifidobacterium/crecimiento & desarrollo , Modelos Animales de Enfermedad , Disbiosis/microbiología , Disbiosis/fisiopatología , Endotoxemia/microbiología , Endotoxemia/fisiopatología , Endotoxinas/biosíntesis , Femenino , Microbioma Gastrointestinal/efectos de los fármacos , Insuficiencia Cardíaca/microbiología , Insuficiencia Cardíaca/fisiopatología , Fenilefrina/administración & dosificación , Esfuerzo Físico , Propionibacterium/crecimiento & desarrollo , RatasRESUMEN
The Russian consensus on exo- and endocrine pancreatic insufficiency after surgical treatment was prepared on the initiative of the Russian "Pancreatic Club" on the Delphi method. His goal was to clarify and consolidate the opinions of specialists on the most relevant issues of diagnosis and treatment of exo- and endocrine insufficiency after surgical interventions on the pancreas. An interdisciplinary approach is provided by the participation of leading gastroenterologists and surgeons.
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Consenso , Insuficiencia Pancreática Exocrina , Páncreas/cirugía , Glucemia/análisis , Insuficiencia Pancreática Exocrina/diagnóstico , Insuficiencia Pancreática Exocrina/etiología , Insuficiencia Pancreática Exocrina/terapia , Heces/química , Hemoglobina Glucada/análisis , Terapia de Reemplazo de Hormonas/métodos , Lipasa/uso terapéutico , Estado Nutricional , Páncreas/enzimología , Páncreas/fisiopatología , Pancreatectomía , Elastasa Pancreática/análisis , Federación de RusiaRESUMEN
Pancreatology Club Professional Medical Community, 1A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 3Kazan State Medical University, Ministry of Health of Russia, Kazan; 4Kazan (Volga) Federal University, Kazan; 5Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk; 6Morozov City Children's Clinical Hospital, Moscow Healthcare Department, Moscow; 7I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg; 8Siberian State Medical University, Ministry of Health of Russia, Tomsk; 9M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow; 10Maimonides State Classical Academy, Moscow; 11V.I. Razumovsky State Medical University, Ministry of Health of Russia, Saratov; 12I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow; 13S.M. Kirov Military Medical Academy, Ministry of Defense of Russia, Saint Petersburg; 14Surgut State Medical University, Ministry of Health of Russia, Surgut; 15City Clinical Hospital Five, Moscow Healthcare Department, Moscow; 16Nizhny Novgorod Medical Academy, Ministry of Health of Russia, Nizhny Novgorod; 17Territorial Clinical Hospital Two, Ministry of Health of the Krasnodar Territory, Krasnodar; 18Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg; 19Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don; 20Omsk Medical University, Ministry of Health of Russia, Omsk; 21Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow; 22Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk; 23Stavropol State Medical University, Ministry of Health of Russia, Stavropol; 24Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo; 25N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 26A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Russian Ministry for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters, Saint Petersburg; 27Research Institute for Medical Problems of the North, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk; 28S.P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow; 29Tver State Medical University, Ministry of Health of Russia, Tver The Russian consensus on the diagnosis and treatment of chronic pancreatitis has been prepared on the initiative of the Russian Pancreatology Club to clarify and consolidate the opinions of Russian specialists (gastroenterologists, surgeons, and pediatricians) on the most significant problems of diagnosis and treatment of chronic pancreatitis. This article continues a series of publications explaining the most significant interdisciplinary consensus statements and deals with enzyme replacement therapy.
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Terapia de Reemplazo Enzimático/métodos , Pancreatitis Crónica , Manejo de la Enfermedad , Humanos , Moscú , Pancreatitis Crónica/diagnóstico , Pancreatitis Crónica/terapiaRESUMEN
BACKGROUND: Ulcerative colitis (UC) is characterised by impaired fatty-acid oxidation; l-carnitine has a key role in fatty-acid metabolism and short-chain fatty acids such as butyrate and propionate are important energy source for intestinal epithelial cells. AIM: To evaluate efficacy and safety of colon-release propionyl-L-carnitine (PLC) in patients with mild-to-moderate UC receiving stable oral aminosalicylate or thiopurine therapy. METHODS: In a multicentre, phase II, double-blind, parallel-group trial, patients were randomised to receive PLC 1 g/day, PLC 2 g/day or placebo. Main inclusion criteria were as follows: age 18-75; disease activity index (DAI) score 3-10 inclusive, be under oral stable treatment with aminosalicylate or thiopurine. The primary endpoint was clinical/endoscopic response, defined as a decrease in DAI score ≥ 3 points or remission, defined as a DAI score ≤ 2 with no individual sub-score > 1. RESULTS: Of 121 patients who were randomised, 57 of 79 (72%) patients receiving PLC (combined 1 g and 2 g cohort) had a clinical/endoscopic response vs. 20 of 40 (50%) receiving placebo (P = 0.02). Specifically, in PLC 1 g/day group, 30 of 40 (75%) patients had clinical/endoscopic response (P = 0.02 vs. placebo) and 27 of 39 (69%) in the PLC 2 g/day group (P = 0.08 vs. placebo). Rates of remission were 22/40 (55%), 19/39 (49%), 14/40 (35%) in the PLC 1 g, PLC 2 g, and placebo groups, respectively. PLC had a similar safety profile to placebo; the most common adverse events were gastrointestinal. CONCLUSION: Propionyl-L-carnitine 1 g/day should be investigated further as a co-treatment for mild-to-moderate ulcerative colitis (NCT-01026857).
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Antiinflamatorios no Esteroideos/administración & dosificación , Carnitina/análogos & derivados , Colitis Ulcerosa/tratamiento farmacológico , Administración Oral , Adulto , Antiinflamatorios no Esteroideos/efectos adversos , Carnitina/administración & dosificación , Carnitina/efectos adversos , Estudios de Cohortes , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Femenino , Humanos , Masculino , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto JovenRESUMEN
Today in Russian Federation, we observe significant growth of the chronic pancreatitis incidence with the depression of its therapy efficiency (more than 20% of the patients) and complications rate growth. In many respects given tendency is associated with the inefficiency of traditional medications combination in the context of inflammation process reduction, gut dysbiosis correction and chronic inflammation reaction depression. Present-day studies indicates, that the grade and character of inflammation in the pancreas depends on the pro- and anti-inflammatory cytokines balance, which is associated with the elevation of the pathogenic microbiota concentration and permeability of the gut. We estimate clinical efficacy of complex treatment regimen (PPI, spasmolytic, multienzyme and prebiotic therapy) in the patients with chronic pancreatitis and its effect on chronic system inflammation. We established that efficacy of modern complex treatment regimen depends on its influence on chronic system inflammation and that prebiotics addition potentiates correction of dysbiotic changes in the gut microbial-tissular complex and reduces grade of system inflammation.
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Colon/microbiología , Fármacos Gastrointestinales/uso terapéutico , Pancreatitis Crónica/tratamiento farmacológico , Parasimpatolíticos/uso terapéutico , Prebióticos , Síndrome de Respuesta Inflamatoria Sistémica/prevención & control , Adulto , Proteína C-Reactiva/análisis , Citocinas/sangre , Interpretación Estadística de Datos , Quimioterapia Combinada , Femenino , Fármacos Gastrointestinales/administración & dosificación , Humanos , Masculino , Omeprazol/administración & dosificación , Omeprazol/uso terapéutico , Páncreas/diagnóstico por imagen , Pancreatina/administración & dosificación , Pancreatina/uso terapéutico , Pancreatitis Crónica/complicaciones , Pancreatitis Crónica/diagnóstico por imagen , Pancreatitis Crónica/inmunología , Pancreatitis Crónica/microbiología , Parasimpatolíticos/administración & dosificación , Fenetilaminas/administración & dosificación , Fenetilaminas/uso terapéutico , Síndrome de Respuesta Inflamatoria Sistémica/sangre , Síndrome de Respuesta Inflamatoria Sistémica/etiología , Síndrome de Respuesta Inflamatoria Sistémica/microbiología , Resultado del Tratamiento , UltrasonografíaAsunto(s)
Ácido Gástrico/metabolismo , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori/efectos de los fármacos , Gastropatías/diagnóstico , Gastropatías/tratamiento farmacológico , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Antiulcerosos/administración & dosificación , Antiulcerosos/uso terapéutico , Quimioterapia Combinada , Infecciones por Helicobacter/etiología , Infecciones por Helicobacter/metabolismo , Humanos , Moscú , Inhibidores de la Bomba de Protones/administración & dosificación , Inhibidores de la Bomba de Protones/uso terapéutico , Federación de Rusia , Gastropatías/etiología , Gastropatías/metabolismoAsunto(s)
Infecciones Comunitarias Adquiridas/tratamiento farmacológico , Intestinos/microbiología , Personal Militar , Neumonía Bacteriana/tratamiento farmacológico , Probióticos/uso terapéutico , Adolescente , Adulto , Antibacterianos/administración & dosificación , Antibacterianos/economía , Antibacterianos/uso terapéutico , Infecciones Comunitarias Adquiridas/economía , Infecciones Comunitarias Adquiridas/microbiología , Análisis Costo-Beneficio , Quimioterapia Combinada , Humanos , Masculino , Neumonía Bacteriana/economía , Neumonía Bacteriana/microbiología , Probióticos/administración & dosificación , Probióticos/economía , Resultado del TratamientoAsunto(s)
Flatulencia/tratamiento farmacológico , Pancreatitis Crónica/tratamiento farmacológico , Silicatos/uso terapéutico , Adulto , Amilasas/metabolismo , Glucemia/metabolismo , Quimioterapia Combinada , Femenino , Flatulencia/etiología , Humanos , Insulina/metabolismo , Lipasa/metabolismo , Lipoproteínas/sangre , Masculino , Pancreatitis Crónica/sangre , Pancreatitis Crónica/complicaciones , Pancreatitis Crónica/enzimología , Calidad de Vida , Silicatos/administración & dosificación , Tripsina/metabolismoAsunto(s)
Antibacterianos/economía , Antibacterianos/uso terapéutico , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori , Compuestos Organometálicos/economía , Compuestos Organometálicos/uso terapéutico , Úlcera Péptica/tratamiento farmacológico , Adulto , Antibacterianos/efectos adversos , Claritromicina/economía , Claritromicina/uso terapéutico , Quimioterapia Combinada , Inhibidores Enzimáticos/uso terapéutico , Femenino , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/economía , Humanos , Masculino , Persona de Mediana Edad , Compuestos Organometálicos/efectos adversos , Úlcera Péptica/economía , Úlcera Péptica/microbiología , Inhibidores de la Bomba de Protones , Resultado del TratamientoAsunto(s)
Úlcera Duodenal/economía , Úlcera Duodenal/terapia , Infecciones por Helicobacter/complicaciones , Helicobacter pylori , Adulto , Úlcera Duodenal/microbiología , Femenino , Costos de la Atención en Salud , Infecciones por Helicobacter/economía , Infecciones por Helicobacter/terapia , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The absence of clinical, biochemical, and instrumental signs that characterize the morphological pattern of the liver presents an urgent problem in the diagnosis of alcoholic hepatitis (AH). Sixty-one patients (mean age 41.7 +/- 8.7 years) were examined to study relationships between the histomorphological parameters and laboratory and instrumental findings in patients with AH on combined treatment including alpha-lipoic acid (Berlition). Indirect assessment of the histological activity of the disease may use the parameters of the serum activity of aspartate aminotransferase and gamma-glutamine aminotransferase, the stages of hepatic fibrosis-ultrasound symptoms: the splenic index at the early stages of the disease, the diameter of the splenic vein in moderate and severe fibrosis. The supplementation of Berlition in the combined therapy for AH decreases the severity of fatty hepatocytic dystrophy, hepatic inflammatory and necrotic changes, no increase or a decrease in the stage of fibrotic changes in the liver tissue.
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Hepatitis Alcohólica/diagnóstico , Hepatitis Alcohólica/patología , Ácido Tióctico/uso terapéutico , Adipocitos/efectos de los fármacos , Adulto , Autopsia , Biopsia , Quimioterapia Combinada , Femenino , Humanos , Masculino , Ácido Tióctico/farmacologíaAsunto(s)
Desnutrición/dietoterapia , Personal Militar , Estado Nutricional/fisiología , Adolescente , Adulto , Índice de Masa Corporal , Humanos , Intestinos/microbiología , Desnutrición/microbiología , Desnutrición/fisiopatología , Evaluación Nutricional , Federación de Rusia , Evaluación de Capacidad de TrabajoRESUMEN
The argument about advantages of certain herniotomy methods has not been settled up to now. Some authors believe that it is reasonable to perform a Shouldice's operation for all inguinal hernias, while others think that it is optimum to use synthetic materials. Certain surgeons prefer endoscopic techniques for recurrent inguinal hernias, etc. In all fairness, it should be acknowledged that none of the currently available hernioplasty methods can ultimately secure against a recurrence of hernia one hundred per cent. Only a differentiated approach to the selection of surgery methods, sufficient surgeon's experience in this field, thorough analysis of remote results of his own operations as well as the use of up-to-date plastic materials, all taken in the aggregate, can considerable improve the results of herniotomy.
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Pancreatitis/tratamiento farmacológico , Adulto , Enfermedad Crónica , Economía Farmacéutica , Femenino , Fármacos Gastrointestinales/economía , Fármacos Gastrointestinales/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Pancreatitis/economíaRESUMEN
There was an analysis of the results of the study of intragastric acidity and acid-base balance (ABB) of the blood in 25 patients with duodenal ulcer. The patients were examined before and against the background of the 14-day monotherapy with one of the following preparations: Losec, 40 mg (omeprazole), famotidine, 80 mg (Quamatel), Phosphalugel, or placebo.