RESUMEN
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. AIM: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. METHODS: The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (Mg BP) (0.69±0.15 mmol/L) and estimates of daily Mg consumption according to dietary diaries (Mg D) (185±90 mg/day). RESULTS: Mg supply was adequate (Mg BP >0.80 mmol/L, Mg D >300 mg/day) in not more than 6 % of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, Ñ=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95 % confidence interval [CI] 10-25, Ñ=0.0006). Mg deficit (Mg BP.
Asunto(s)
Deficiencia de Magnesio , Adolescente , Adulto , Estudios Transversales , Humanos , Magnesio , Persona de Mediana Edad , Federación de Rusia , Adulto JovenRESUMEN
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. AIM: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. METHODS: The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (MgBP) (0.69±0.15 mmol/L) and estimates of daily Mg consumption according to dietary diaries (MgD) (185±90 mg/day). RESULTS: Mg supply was adequate (MgBP >0.80 mmol/L, MgD >300 mg/day) in not more than 6% of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, Ñ=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95% confidence interval [CI] 10-25, Ñ=0.0006). Mg deficit (MgBP.
Asunto(s)
Dieta , Deficiencia de Magnesio , Adolescente , Adulto , Estudios Transversales , Humanos , Magnesio , Persona de Mediana Edad , Oportunidad Relativa , Federación de Rusia , Adulto JovenRESUMEN
Hopantenic acid is a well-known nootropic drug similar in its chemical structure to pantothenic acid (vitamin B5). Neurotropic effects of hopantenic acid act through binding with delta- and kappa opioid receptors, modulation of acetylcholine secretion and relationship with dopamine receptors. Besides neurotropic effects, hopantenic acid may modulate the metabolism of prostaglandins, steroids and have antitumor effects.
RESUMEN
Magnesium deficiency is associated with impaired vascular tone bidirectionally and can lead to both an abnormal increase and abnormal lowering of blood pressure. This article analyzes studies on the relationship between blood pressure parameters and the level of magnesium in the blood. Evidence base for the use of magnesium for correction of vascular tone is presented.
Asunto(s)
Presión Sanguínea , Deficiencia de Magnesio , Magnesio , Contracción Muscular , Músculo Liso Vascular , Presión Sanguínea/efectos de los fármacos , Presión Sanguínea/fisiología , Cardiotónicos/uso terapéutico , Humanos , Magnesio/sangre , Magnesio/uso terapéutico , Deficiencia de Magnesio/complicaciones , Deficiencia de Magnesio/metabolismo , Deficiencia de Magnesio/fisiopatología , Deficiencia de Magnesio/terapia , Contracción Muscular/efectos de los fármacos , Contracción Muscular/fisiología , Músculo Liso Vascular/metabolismo , Músculo Liso Vascular/fisiopatología , Ensayos Clínicos Controlados Aleatorios como AsuntoRESUMEN
Magnesium is principally important for maintenance of function of cardiomyocytes. Magnesium deficit provokes asthenia of cardiomyocytes accompanying cardiovascularpathology. In this paper we present results of conducted for the first time bioinformatic analysis of magnesium dependent mitochondrial proteins. The results have principal significance for understanding pharmacodynamics effects of action of magnesium on function of mitochondria.
Asunto(s)
Magnesio , Mitocondrias , Proteínas Mitocondriales/metabolismo , Miocitos Cardíacos , Biología Computacional/métodos , Humanos , Magnesio/metabolismo , Magnesio/farmacocinética , Mitocondrias/efectos de los fármacos , Mitocondrias/fisiología , Miocitos Cardíacos/efectos de los fármacos , Miocitos Cardíacos/fisiologíaAsunto(s)
Pulpa Dental/fisiología , Potenciales Evocados Somatosensoriales/efectos de los fármacos , Antagonistas de la Serotonina/farmacología , Serotonina/farmacología , Corteza Somatosensorial/fisiología , Animales , Indoles/farmacología , Dietilamida del Ácido Lisérgico/farmacología , Morfina/farmacología , ConejosRESUMEN
The primary responses of the dental areas of the brain cortex in anesthetized rabbits were recorded to demonstrate that application of the alpha-adrenomimetic noradrenaline and beta-adrenolytic propranolol to the cortex suppressed, while application of the beta-adrenomimetic isadrin and alpha-adrenolytic phentolamine potentiated the electrical responses to nociceptive stimulation of the dental pulp. It was found that phentolamine exerted dissimilar effects.