RESUMEN
We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2. None of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral RNA was detected in several animals. Further, neutralizing antibody titres were low or non-existent one month following infection. These results suggest that domestic livestock are unlikely to contribute to SARS-CoV-2 epidemiology.
Asunto(s)
COVID-19/veterinaria , Especificidad del Huésped , Ganado/virología , SARS-CoV-2/patogenicidad , Animales , Anticuerpos Neutralizantes/sangre , Anticuerpos Neutralizantes/inmunología , Anticuerpos Antivirales/sangre , Anticuerpos Antivirales/inmunología , COVID-19/inmunología , COVID-19/virología , Camélidos del Nuevo Mundo/virología , Bovinos/virología , Chlorocebus aethiops , Reservorios de Enfermedades/virología , Cabras/virología , Caballos/virología , Especificidad del Huésped/inmunología , Humanos , Cavidad Nasal/virología , ARN Viral/análisis , Conejos/virología , Recto/virología , Sistema Respiratorio/virología , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación , Ovinos/virología , Especificidad de la Especie , Células Vero , Esparcimiento de Virus , Vísceras/virologíaRESUMEN
Wild animals have been implicated as the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but it is largely unknown how the virus affects most wildlife species and if wildlife could ultimately serve as a reservoir for maintaining the virus outside the human population. We show that several common peridomestic species, including deer mice, bushy-tailed woodrats, and striped skunks, are susceptible to infection and can shed the virus in respiratory secretions. In contrast, we demonstrate that cottontail rabbits, fox squirrels, Wyoming ground squirrels, black-tailed prairie dogs, house mice, and racoons are not susceptible to SARS-CoV-2 infection. Our results expand the knowledge base of susceptible species and provide evidence that human-wildlife interactions could result in continued transmission of SARS-CoV-2.