RESUMEN
Ceruloplasmin (CP) is a copper containing oxidase of human plasma alpha 2-globulin fraction. The review summarizes literature data on biological role of CP under normal conditions and during development of malignant tumor. This protein may be involved both into antitumor deference and also into metastasizing process. Although CP has already been employed into intensive therapy of oncologic patients all mechanisms underlying its biological activity remain to be clarified.
Asunto(s)
Antineoplásicos/uso terapéutico , Ceruloplasmina/fisiología , Ceruloplasmina/uso terapéutico , Quelantes/uso terapéutico , Neoplasias/tratamiento farmacológico , Anticuerpos/sangre , Biomarcadores de Tumor/sangre , Ceruloplasmina/inmunología , Quelantes/química , Cobre/química , Humanos , Neoplasias/enzimologíaRESUMEN
Serum ceruloplasmih (CP) and anti-CP antibody levels were studied by the oxidase method in 18 healthy women and in 86 women with gynecological tumors. The results demonstrate that: 1) Serum CP concentrations increased in endometrial and ovarian cancer, in benign ovarian tumors and to a lesser extent in mioma of uterus. 2) Serum CP antibodies were found out in both benign tumors and cancer cases. 3) There was positive linear correlation between serum levels of CP and anti-CP-antibodies in endometrial and ovarian cancers, and in benign ovarian tumors.
