1.
Beilstein J Org Chem
; 17: 730-736, 2021.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33796160
RESUMEN
The first total synthesis of the pyrrolo[2,3-c]quinoline alkaloid trigonoine B (1) was accomplished via a six-step sequence involving the construction of an N-substituted 4-aminopyrrolo[2,3-c]quinoline framework via electrocyclization of 2-(pyrrol-3-yl)benzene containing a carbodiimide moiety as a 2-azahexatriene system. The employed six-step sequence afforded trigonoine B (1) in 9.2% overall yield. The described route could be employed for the preparation of various N-substituted 4-aminopyrroloquinolines with various biological activities.
2.
Ann Hematol
; 99(5): 1153-1155, 2020 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32270216