Numerical Analysis on Gas Production and Geomechanical Responses of Natural Gas Hydrate Reservoirs.

Natural gas hydrate (NGH) has attracted considerable global attention as a promising energy resource in recent years. To acquire valuable insights into regarding the interplay between mechanical properties and production outcomes during the production, in this study, a fully coupled thermo-hydro-mechanical-chemical (THMC) model based on the geological features of reservoirs in the Shenhu area of the South China Sea (SCS) was developed to analyze the response characteristics of various physical fields within the reservoir during the exploitation. Furthermore, the study examined the influence of mechanical behavior on hydrate exploitation and investigated the effects of varying initial hydrate saturation and seawater depth on production efficiency and reservoir deformation. The simulation results indicated that neglecting the impact of solid mechanics in the analysis of hydrate productivity can result in overestimated results, particularly during the initial production stage. Reservoirs with higher hydrate saturation experience lower initial production rates due to the influence of permeability and capillary force. Moreover, reservoirs with high hydrate saturation exhibit greater compression but lower wellhead subsidence during the long-term development. The impact of seawater depth on production capacity primarily arises from the pressure's influence on the gas-water ratio, where greater seawater depth corresponds to increased reservoir compression and wellhead subsidence.

Soil consolidation acoustic experiment and pore pressure prediction model establishment-taking the Yingqiong Basin as an example.

To establish a pore pressure prediction model suitable for the Yingqiong Basin in the South China Sea. A new laboratory test method was designed to simulate the core consolidation process, and an acoustic experiment for soil consolidation was carried out to analyze various parameters and establish an abnormal pore pressure prediction model suitable for the target block. First, the cause of abnormally high pressure in the Yingqiong Basin is analyzed and identified, and a simulation experiment of stratum loading and unloading is performed. The soil consolidation, experimental equipment and experimental plan are designed. Several sets of experiments were carried out, the changes in various parameters during the experiment were analyzed and summarized, the pore pressure prediction model suitable for this area was standardized and established, and application verification and evaluation were carried out in some wells in this area. The results show that the prediction model is accurate and applicable, and the pore pressure can be predicted by the soil consolidation experiment method that the prediction accuracy is slightly better than the traditional prediction model. In this study, a feasible soil consolidation acoustic experiment method can be used to establish a rock mechanics experiment and a pore pressure prediction model without strict core rock. The experiments have proved the feasibility of this method and obtained two prediction models, including loading mechanism and unloading mechanism prediction models.

Enhanced removal of scaling cations from oilfield produced water by carrier mineral floatation.

This work reports a novel carrier flotation protocol for removing scaling cations from an oilfield produced water source which significantly reduces the collector consumption by employing natural minerals such as quartz, montmorillonite and talcum as the scaling cations carriers. The scaling cations uptake onto all carrier minerals exhibited homogeneous and monolayer adsorption, which was mainly dominated by physisorption. After adding oleate collector, the scaling cations removal rate was further enhanced, which was attributed to its high affinity with the scaling cations. Notably, the talcum flotation process simultaneously offered a high scaling cations removal rate (76.1%) and mineral recovery rate (98.3%), which achieved a sediment yield reduction of 72.2%. By summarizing the characterization results, the scaling cations removal mechanisms were also proposed. Moreover, high regeneration efficiencies (86.1% and 84.8% for quartz and talcum regeneration within three cycles) were achieved by the proposed regeneration protocol. This carrier flotation protocol with its low collector consumption offered technical promise for scaling cations removal from oilfield produced water.

Targetable Conformationally Restricted Cyanines Enable Photon-Count-Limited Applications*.

Cyanine dyes are exceptionally useful probes for a range of fluorescence-based applications, but their photon output can be limited by trans-to-cis photoisomerization. We recently demonstrated that appending a ring system to the pentamethine cyanine ring system improves the quantum yield and extends the fluorescence lifetime. Here, we report an optimized synthesis of persulfonated variants that enable efficient labeling of nucleic acids and proteins. We demonstrate that a bifunctional sulfonated tertiary amide significantly improves the optical properties of the resulting bioconjugates. These new conformationally restricted cyanines are compared to the parent cyanine derivatives in a range of contexts. These include their use in the plasmonic hotspot of a DNA-nanoantenna, in single-molecule Förster-resonance energy transfer (FRET) applications, far-red fluorescence-lifetime imaging microscopy (FLIM), and single-molecule localization microscopy (SMLM). These efforts define contexts in which eliminating cyanine isomerization provides meaningful benefits to imaging performance.

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis.

ABSTRACT: To evaluate the effect of astragaloside IV for hepatic fibrosis.The multiple databases like Pubmed, Embase, Cochrane databases, and China National Knowledge database were used to search for the relevant studies, and full-text articles involved in the evaluation on effect of astragaloside IV for hepatic fibrosis. Review Manager 5.2 was adopted to estimate the effects of the results among selected articles. Forest plots, sensitivity analysis and bias analysis for the articles included were also conducted.Finally, 7 eligible studies were eventually satisfied the included criteria. Alanine aminotransferase (ALT) in model was higher than astragaloside group (mean difference [MD] = -58.01, 95% confidential interval (CI) [-93.97, -22.05], P = .002; I2 = 99%). The meta-analysis suggested that aspartate aminotransferase (AST) in model group was more than that in astragaloside group (MD = -39.94, 95% CI [-129.38, 49.50], P = .38; I2 = 100%). Model group had higher α - smooth muscle actin (α-SMA) than astragaloside group (MD was -1.13, P of heterogeneity <.0001, I2 = 94%, Z = 5.18, P of over effect <.0001). Transforming growth factor ß (TGF-ß) in model group was higher than that in astragaloside group (MD was -0.55, P of heterogeneity <.00001, I2 = 97%, Z = 2.54, P of over effect = .01). Limited publication bias was observed in this study.Astragaloside IV is a potential clinical drug for the treatment of liver fibrosis considering liver function and hepatic fibrosis related protein factor in experimental rats are improved.

Author Correction: A lake data set for the Tibetan Plateau from the 1960s, 2005, and 2014.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Long noncoding RNAs, emerging and versatile regulators of tumor-induced angiogenesis.

Angiogenesis is an essential step in maintaining tumor growth and facilitating metastasis. The regulatory mechanisms of tumor-induced angiogenesis are extremely complicated, and include sophisticated crosstalk between tumors and surrounding microenvironment cells, oncogenic signaling pathway activation and aberrant expression of angiogenesis-related genes. Recently, emerging evidence demonstrated that long noncoding RNAs (lncRNAs) play crucial roles in angiogenesis. However, there are lack of reports to review the progression in this scientific field. Here, we focus on and summarize the latest findings of lncRNA in angiogenesis in various cancers. Firstly, we introduced how lncRNAs in tumor cells to modulate the cellular signaling axis, interact with proteins and serve as competitive endogenous RNAs (ceRNAs) to alter target gene expression, by which induce endothelial cell to form capillaries. Then, we recapitulated the essential functions of lncRNA in endothelial cells, and how lncRNAs in tumor-associated macrophages to mediate angiogenesis. Next, the angiogenesis mechanism of tumor-derived lncRNAs via exosomes were collectively described. At last, the effects of lncRNAs on vasculogenic mimicry were summarized, which showed that malignant tumor cells acquire dedifferentiated and endothelial properties to form vessel-like structures by themselves. This review provides new insights into the complexity of angiogenesis, and suggests that lncRNAs may become promising biomarkers and targets for enhancing the efficacy of anti-angiogenesis therapy in cancer.

Effect of Al⁻Zn Alloy Coating on Corrosion Fatigue Behavior of X80 Riser Steel.

This paper presents a corrosion fatigue cyclic failure test for X80 steel, which has arc sprayed with an Al-Zn coating in natural seawater under different stress levels. We found that the Al-Zn coating can significantly improve the corrosion fatigue resistance and slow the crack initiation of X80 steel. The effect of the Al-Zn coating on the corrosion fatigue crack initiation is mainly attributed to its physical isolation, cathodic protection and residual prestress while the effect on crack propagation is due to its inhibition of the formation and evolution of secondary cracks. Moreover, according to the test results, a new life prediction model for corrosion fatigue based on the damage evolution law is proposed and the effect of corrosion-fatigue coupling damage in the proposed model is also considered.

A comprehensive data set of lake surface water temperature over the Tibetan Plateau derived from MODIS LST products 2001-2015.

Lake surface water temperature (LSWT) is sensitive to long-term changes in thermal structure of lakes and regional air temperature. In the context of global climate change, recent studies showed a significant warming trend of LSWT based on investigating 291 lakes (71% are large lakes, ≥50 km2 each) globally. However, further efforts are needed to examine variation in LSWT at finer regional spatial and temporal scales. The Tibetan Plateau (TP), known as 'the Roof of the World' and 'Asia's water towers', exerts large influences on and is sensitive to regional and even global climates. Aiming to examine detailed changing patterns and potential driven mechanisms for temperature variations of lakes across the TP region, this paper presents the first comprehensive data set of 15-year (2001-2015) nighttime and daytime LSWT for 374 lakes (≥10 km2 each), using MODIS (Moderate Resolution Imaging Spectroradiometer) Land Surface Temperature (LST) products as well as four lake boundary shapefiles (i.e., 2002, 2005, 2009, and 2014) derived from Landsat/CBERS/GaoFen-1 satellite images. The data set itself reveals significant information on LSWT and its changes over the TP and is an indispensable variable for numerous applications related to climate change, water budget analysis (particularly lake evaporation), water storage changes, glacier melting and permafrost degradation, etc.

A lake data set for the Tibetan Plateau from the 1960s, 2005, and 2014.

Long-term datasets of number and size of lakes over the Tibetan Plateau (TP) are among the most critical components for better understanding the interactions among the cryosphere, hydrosphere, and atmosphere at regional and global scales. Due to the harsh environment and the scarcity of data over the TP, data accumulation and sharing become more valuable for scientists worldwide to make new discoveries in this region. This paper, for the first time, presents a comprehensive and freely available data set of lakes' status (name, location, shape, area, perimeter, etc.) over the TP region dating back to the 1960s, including three time series, i.e., the 1960s, 2005, and 2014, derived from ground survey (the 1960s) or high-spatial-resolution satellite images from the China-Brazil Earth Resources Satellite (CBERS) (2005) and China's newly launched GaoFen-1 (GF-1, which means high-resolution images in Chinese) satellite (2014). The data set could provide scientists with useful information for revealing environmental changes and mechanisms over the TP region.

Have GRACE satellites overestimated groundwater depletion in the Northwest India Aquifer?

The Northwest India Aquifer (NWIA) has been shown to have the highest groundwater depletion (GWD) rate globally, threatening crop production and sustainability of groundwater resources. Gravity Recovery and Climate Experiment (GRACE) satellites have been emerging as a powerful tool to evaluate GWD with ancillary data. Accurate GWD estimation is, however, challenging because of uncertainties in GRACE data processing. We evaluated GWD rates over the NWIA using a variety of approaches, including newly developed constrained forward modeling resulting in a GWD rate of 3.1 ± 0.1 cm/a (or 14 ± 0.4 km(3)/a) for Jan 2005-Dec 2010, consistent with the GWD rate (2.8 cm/a or 12.3 km(3)/a) from groundwater-level monitoring data. Published studies (e.g., 4 ± 1 cm/a or 18 ± 4.4 km(3)/a) may overestimate GWD over this region. This study highlights uncertainties in GWD estimates and the importance of incorporating a priori information to refine spatial patterns of GRACE signals that could be more useful in groundwater resource management and need to be paid more attention in future studies.