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Bioorg Med Chem Lett
; 15(8): 2103-6, 2005 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15808477
RESUMEN
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharmacokinetic and acute efficacy studies on this compound are also presented.