RESUMEN
The herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of natural antivirals. Flavonoids have demonstrated promise in combating various viruses, including those within the herpesvirus family. This review, delving into recent studies, reveals the intricate mechanisms by which flavonoids decode their antiviral capabilities against HSV. By disrupting key stages of the viral life cycle, such as attachment to host cells, entry, DNA replication, latency, and reactivation, flavonoids emerge as formidable contenders in the ongoing battle against HSV infections.
Asunto(s)
Herpes Simple , Herpesvirus Humano 1 , Humanos , Animales , Antivirales/farmacología , Antivirales/uso terapéutico , Flavonoides/farmacología , Flavonoides/uso terapéutico , Herpes Simple/tratamiento farmacológico , Herpesvirus Humano 1/fisiología , Estadios del Ciclo de VidaRESUMEN
Herpesviruses, a family of enveloped DNA viruses, pose significant threats to both humans and animals [...].
