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The scale-up of laboratory procedures to industrial production is the main challenge standing between ideation and the successful introduction of novel materials into commercial products. Retaining quality while ensuring high per-batch production yields is the main challenge. Batch processing and other dynamic strategies that preserve product quality can be applied, but they typically involve a variety of experimental parameters and functions that are difficult to optimize because of interdependencies that are often antagonistic. Adaptive Bayesian optimization is demonstrated here as a valuable support tool in increasing both the per-batch yield and quality of short polymer fibers, produced by wet spinning and shear dispersion methods. Through this approach, it is shown that short fiber dispersions with high yield and a specified, targeted fiber length distribution can be obtained with minimal cost of optimization, starting from sub-optimal processing conditions and minimal prior knowledge. The Bayesian function optimization demonstrated here for batch processing could be applied to other dynamic scale-up methods as well as to cases presenting higher dimensional challenges such as shape and structure optimization. This work shows the great potential of synergies between industrial processing, material engineering, and machine learning perspectives.
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The discovery of processes for the synthesis of new materials involves many decisions about process design, operation, and material properties. Experimentation is crucial but as complexity increases, exploration of variables can become impractical using traditional combinatorial approaches. We describe an iterative method which uses machine learning to optimise process development, incorporating multiple qualitative and quantitative objectives. We demonstrate the method with a novel fluid processing platform for synthesis of short polymer fibers, and show how the synthesis process can be efficiently directed to achieve material and process objectives.
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Questions about how to regulate nanoenhanced products regularly arise as researchers determine possible nanoparticle transformation(s). Focusing concern on the incorporation and subsequent release of nano-Ag in fabrics often overshadows the fact that many "conventional silver" antimicrobials such as ionic silver, AgCl, metallic Ag, and other forms will also form different species of silver. In this study we used a laboratory washing machine to simulate the household laundering of a number of textiles prepared with known conventional Ag or nano-Ag treatments and a commercially available fabric incorporating yarns coated with bulk metallic Ag. Serial filtration allowed for quantification of total Ag released in various size fractions (>0.45 µm, < 0.45 µm, <0.1 µm, and <10 kDa), while characterization of particles with TEM/EDX provided insight on Ag transformation mechanisms. Most conventional Ag additives yielded more total Ag and more nanoparticulate-sized Ag in the washing liquid than fabrics that used nano-Ag treatments. Incorporating nano-silver into the fiber (as opposed to surface treatments) yielded less total Ag during fabric washing. A variety of metallic Ag, AgCl, and Ag/S particles were observed in washing solution by TEM/EDX to various extents depending on the initial Ag speciation in the fabrics. Very similar particles were also observed when dissolved ionic Ag was added directly into the washing liquid. On the basis of the present study, we can state that all silver-treated textiles, regardless of whether the treatment is "conventional" or "nano", can be a source of silver nanoparticles in washing solution when laundering fabrics. Indeed, in this study we observed that textiles treated with "conventional" silver have equal or greater propensity to form nano-silver particles during washing conditions than those treated with "nano"-silver. This fact needs to be strongly considered when addressing the risks of nano-silver and emphasizes that regulatory assessment of nano-silver warrants a similar approach to conventional silver.
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Contaminantes Ambientales/análisis , Nanopartículas del Metal/análisis , Plata/química , Textiles/análisis , Aguas Residuales/química , Contaminantes Ambientales/química , Nanopartículas del Metal/química , Tamaño de la PartículaRESUMEN
Many antimicrobial technologies are available for textiles. They may be used in many different textile applications to prevent the growth of microorganisms. Due to the biological activity of the antimicrobial compounds, the assessment of the safety of these substances is an ongoing subject of research and regulatory scrutiny. This review aims to give an overview on the main compounds used today for antimicrobial textile functionalization. Based on an evaluation of scientific publications, market data as well as regulatory documents, the potential effects of antimicrobials on the environment and on human health were considered and also life cycle perspectives were taken into account. The characteristics of each compound were summarized according to technical, environmental and human health criteria. Triclosan, silane quaternary ammonium compounds, zinc pyrithione and silver-based compounds are the main antimicrobials used in textiles. The synthetic organic compounds dominate the antimicrobials market on a weight basis. On the technical side the application rates of the antimicrobials used to functionalize a textile product are an important parameter with treatments requiring lower dosage rates offering clear benefits in terms of less active substance required to achieve the functionality. The durability of the antimicrobial treatment has a strong influence on the potential for release and subsequent environmental effects. In terms of environmental criteria, all compounds were rated similarly in effective removal in wastewater treatment processes. The extent of published information about environmental behavior for each compound varies, limiting the possibility for an in-depth comparison of all textile-relevant parameters across the antimicrobials. Nevertheless the comparative evaluation showed that each antimicrobial technology has specific risks and benefits that should be taken into account in evaluating the suitability of different antimicrobial products. The results also indicated that nanoscale silver and silver salts that achieve functionality with very low application rates offer clear potential benefits for textile use. The regular care of textiles consumes lots of resources (e.g. water, energy, chemicals) and antimicrobial treatments can play a role in reducing the frequency and/or intensity of laundering which can give potential for significant resource savings and associated impact on the environment.
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Antiinfecciosos , Textiles , Contaminantes Ambientales , Humanos , Ropa de Protección , Medición de Riesgo , PlataRESUMEN
Nanosilver is one nanomaterial that is currently under a lot of scrutiny. Much of the discussion is based on the assumption that nanosilver is something new that has not been seen until recently and that the advances in nanotechnology opened completely new application areas for silver. However, we show in this analysis that nanosilver in the form of colloidal silver has been used for more than 100 years and has been registered as a biocidal material in the United States since 1954. Fifty-three percent of the EPA-registered biocidal silver products likely contain nanosilver. Most of these nanosilver applications are silver-impregnated water filters, algicides, and antimicrobial additives that do not claim to contain nanoparticles. Many human health standards for silver are based on an analysis of argyria occurrence (discoloration of the skin, a cosmetic condition) from the 1930s and include studies that considered nanosilver materials. The environmental standards on the other hand are based on ionic silver and may need to be re-evaluated based on recent findings that most silver in the environment, regardless of the original silver form, is present in the form of small clusters or nanoparticles. The implications of this analysis for policy of nanosilver is that it would be a mistake for regulators to ignore the accumulated knowledge of our scientific and regulatory heritage in a bid to declare nanosilver materials as new chemicals, with unknown properties and automatically harmful simply on the basis of a change in nomenclature to the term "nano".
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Nanoestructuras/historia , Política Pública , Plata/química , Plata/normas , Contaminación Ambiental , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Hidrogeles , Iones , Nanopartículas , Nanoestructuras/normas , Nanotecnología/historia , Plata/efectos adversos , Compuestos de Plata/efectos adversos , Compuestos de Plata/química , Compuestos de Plata/normas , Estados UnidosRESUMEN
Nanotechnology enables development and production of novel silver-based composite materials. We used in vitro tests to demonstrate the antimicrobial activity of a silver-silica nanocomposite compared to the activities of conventional materials, such as silver nitrate and silver zeolite. A silver-silica-containing polystyrene material was manufactured and shown to possess strong antimicrobial properties.
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Antiinfecciosos/farmacología , Antifúngicos/farmacología , Nanocompuestos , Dióxido de Silicio/farmacología , Plata/farmacología , Antiinfecciosos/química , Antifúngicos/química , Bacterias/efectos de los fármacos , Hongos/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Dióxido de Silicio/química , Plata/químicaRESUMEN
Carbon nanotubes are observed to form under a wide range of temperatures, pressures, reactive agents, and catalyst metals. In this paper we attempt to rationalize this body of observations reported in the literature in terms of fundamental processes driving nanotube formation. Many of the observed effects can be attributed to the interaction of three key processes: surface catalysis and deposition of carbon, diffusive transport of carbon, and precipitation effects. A new nanotube formation mechanism is proposed that describes the nanotube structures observed experimentally in a premixed flame and can account for certain shortcomings of the prevailing mechanism that has been repeatedly applied to explain nanotube formation in nonflame environments. The interacting particle model (IPM) attributes the initiation of nanotube growth to the physical interaction between catalyst particles. Coalescence of two (or more) catalyst particles leads to partial blocking of the particle surface, causing a disparity in carbon deposition over the particle surface. The resulting concentration gradient generates a net diffusive flux toward the interparticle contact point. Dimers that separate in this condition can support continuous nanotube growth between the particles. The model can also be extended to multiple particles to account for more complex morphologies. The IPM is consistent with many of the structures observed in the flame-produced material. The validity of the model is evaluated through analysis of diffusion dynamics and a force analysis of particle binding and separation. The IPM is also discussed in relation to identifying the requirements and best conditions to support nanotube growth in the premixed flame. The formation of nanotubes between particles as described by the IPM indicates that a single mechanism cannot completely describe nanotube synthesis; more likely, multiple pathways exist with varying rates that depend on specific process conditions.