[Bronchioloalveolar carcinoma of the lung associated with a highly positive pANCA-titer and clinical signs of microscopic polyangiitis]. / Bronchioloalveoläres Karzinom der Lunge assoziiert mit einem hochpositiven pANCA-Titer und dem klinischen Bild einer mikroskopischen Polyangiitis.

Autoimmune paraneoplastic processes are investigated in detail concerning the Lambert-Eaton-Myasthenic-Syndrome for bronchial carcinomas. For the cutaneous leukocytoclastic vasculitis as a non-ANCA-associated vasculitis the paraneoplastic genesis is described. Litttle is known about ANCA-associated vasculitis as a paraneoplastic autoimmune phenomenon. We present the case of a 62 year old woman referred to our hospital presenting air-space shadows mainly in both upper lobes, skin rash with petechial bleeding and a highly positive pANCA-titer. A bronchioloalveolar carcinoma was diagnosed by surgical biopsy. The patient developed renal failure postsurgically and died a few weeks after the diagnosis was established. This is the 5 (th) case in literature of the temporal concurrence of a bronchial carcinoma and an ANCA-associated vasculitis. So far only 24 cases of a solid tumor occuring simultaneously with an ANCA-positive vasculitis are reported in literature.

[Pregnancy, labor and fetal outcome in females over 40 years of age]. / Schwangerschaft, Geburtsverlauf und Fetal Outcome bei Frauen über 40 Jahre.

In a retrospective Cohort-Study, pregnancy, mode of delivery and foetal outcome were reviewed in patients over forty years of age. These data were compared with the data of patients of 20 to 30 years of age in a statistically standardised manner. The ratio of gestosis was higher in the older group, as was also the ratio of Caesarian section. However, there was no difference in the mode of delivery and foetal outcome. Maternal and foetal morbidity were the same in both groups.