1.
Chem Commun (Camb)
; 59(81): 12172-12175, 2023 Oct 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37747122
RESUMEN
We report a series of membrane-intercalating conjugated oligoelectrolytes (MICOEs) to probe how structural features impact bacterial membrane integrity and antibiotic activity. Minimum inhibitory concentrations (MICs) and outer membrane (OM) permeability correlated to different structural parameters suggesting that the antimicrobial mechanism is not related to OM permeabilization. However, lipid order parameters and MICs correlated to the same structural feature suggesting a possible link.