RESUMEN
Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an advanced ovarian mixed germ cell tumour who underwent fertility-saving surgery followed by a chemotherapy regimen of cisplatin, vinblastine and peplomycin. The patient was disease-free 8 years after initial presentation. She conceived and gestated dichorionic twins after IVF-embryo transfer. To the best of our knowledge, the patient is the first to be treated successfully with the combination chemotherapy regimen and then conceive safely using assisted reproductive technology (ART).
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Fertilización In Vitro , Neoplasias de Células Germinales y Embrionarias/terapia , Neoplasias Ováricas/terapia , Embarazo Múltiple , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Cisplatino/administración & dosificación , Cisplatino/uso terapéutico , Terapia Combinada , Femenino , Humanos , Recién Nacido , Infertilidad Femenina/etiología , Masculino , Neoplasias de Células Germinales y Embrionarias/cirugía , Neoplasias Ováricas/cirugía , Peplomicina/administración & dosificación , Peplomicina/uso terapéutico , Enfermedades Peritoneales/complicaciones , Enfermedades Peritoneales/patología , Embarazo , Resultado del Embarazo , Adherencias Tisulares , Gemelos , Vinblastina/administración & dosificación , Vinblastina/uso terapéuticoRESUMEN
Intrauterine growth restriction (IUGR) has a multifactorial pathogenesis and is an important cause of perinatal mortality. The relationship between fetal weight and placental blood flow in an animal model of IUGR has been investigated, showing that fetal growth is regulated by placental blood flow. The aim of the present study was to determine whether ischemia-reperfusion (I/R) injury stimulates the prostaglandin E2 (PGE2) system or the vascular endothelial growth factor (VEGF) system in the placenta of a rat IUGR model. COX-2 is reported to be involved in ischemic damage in many organs. There are 4 types of PGE2 receptor (EP1, EP2, EP3 and EP4). It is well known that EP1 and EP3 is associated with vasoconstriction. In the present study, vessels were occluded in the right uterine horn on day 17 of pregnancy in rats, and the clamps were removed after 30 min of ischemia. At 24h, 48 h, and 5 days after I/R injury, the live fetuses and placentas were obtained by cesarean section. This study revealed that I/R injury caused IUGR 5 days after the treatment. COX-2 expression and EP3 receptor expression were significantly elevated at 24h after I/R injury, but VEGF mRNA expression was not altered in the placenta from the ischemic horn compared with the non-ischemic horn. These results suggested that induction of the COX-2-EP3 system in the placenta may be one of the causes of IUGR induced by uterine ischemia, because the EP3 receptor and PGE2 are well known to mediate vasoconstriction in many organs.
Asunto(s)
Ciclooxigenasa 2/metabolismo , Retardo del Crecimiento Fetal/metabolismo , Receptores de Prostaglandina E/metabolismo , Animales , Modelos Animales de Enfermedad , Femenino , Peso Fetal , Inmunohistoquímica , Placenta/metabolismo , Embarazo , ARN Mensajero/metabolismo , Ratas , Ratas Sprague-Dawley , Subtipo EP3 de Receptores de Prostaglandina E , Daño por Reperfusión/metabolismo , Factores de Tiempo , Útero/irrigación sanguínea , Factor A de Crecimiento Endotelial Vascular/metabolismoRESUMEN
Bovine colostrum whey and immunoglobulins were prepared. Their characteristics and anti-viral activities were studied:IgG, IgA and IgM were found in bovine colostrum. Most IgG was polymerized. Although neutralization activities against bovine, simian and human rotaviruses existed, anti-human adenovirus antibody was not found. Effects on prophylaxis and treatment for rotavirus gastroenteritis were expected.
