1.
Chem Pharm Bull (Tokyo)
; 57(12): 1431-3, 2009 Dec.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19952459
RESUMEN
We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D(3) (1alpha,25(OH)(2)D(3), 1) and its C14-epimer with the previtamin D(3) form of 14-epi-1alpha,25(OH)(2)preD(3) (14-epi-pre1). Their vitamin D receptor (VDR) binding affinity and osteocalcin promoter transactivation activity in HOS cells were evaluated, and had lower activity than the natural hormone (1) and 14-epi-pre1, respectively.