RESUMEN
In this study, effects of alcalase on physical properties, pepsin digestibility, and antioxidative activity in the heat-induced surimi gel were investigated to develop a novel gel product for people with dysphagia. The heat-induced gelation profile of surimi showed that alcalase activity was maximized at approximately 37 °C. The surimi gel attained an appropriate texture for people with dysphagia, when a combination of 0.3-0.5% alcalase and two-step heating at 37 °C and 90 °C was used. Adding alcalase effectively promoted proteolysis, resulting in softening of the gel. Furthermore, the gel with 0.5% alcalase showed improved pepsin digestibility, when heated at 37 °C and 90 °C. Its antioxidative activity was enhanced by adding 0.5% alcalase. Therefore, a combination of 0.5% alcalase and the two-step heating at 37 °C and 90 °C was useful in improving the physical and functional properties of the surimi gel for people with dysphagia.
Asunto(s)
Productos Pesqueros , Proteínas de Peces en la Dieta/química , Geles/química , Subtilisinas/química , Animales , Antioxidantes/química , Trastornos de Deglución/dietoterapia , Electroforesis en Gel de Poliacrilamida , Gadiformes , Calor , Humanos , Pepsina A/metabolismo , TemperaturaAsunto(s)
Dermatitis Atópica/complicaciones , Dermatitis Atópica/tratamiento farmacológico , Glucocorticoides/uso terapéutico , Penfigoide Ampolloso/complicaciones , Penfigoide Ampolloso/tratamiento farmacológico , Prednisolona/uso terapéutico , Administración Oral , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Autoantígenos/inmunología , Quimiocina CCL17/sangre , Complemento C3/metabolismo , Dermatitis Atópica/inmunología , Dermatitis Atópica/patología , Ensayo de Inmunoadsorción Enzimática , Femenino , Técnica del Anticuerpo Fluorescente Directa , Glucocorticoides/administración & dosificación , Humanos , Inmunoglobulina E/sangre , Inmunoglobulina E/metabolismo , Inmunoglobulina G/sangre , Inmunoglobulina G/metabolismo , Persona de Mediana Edad , Minociclina/administración & dosificación , Minociclina/uso terapéutico , Colágenos no Fibrilares/inmunología , Penfigoide Ampolloso/inmunología , Penfigoide Ampolloso/patología , Prednisolona/administración & dosificación , Índice de Severidad de la Enfermedad , Piel/patología , Colágeno Tipo XVIIAsunto(s)
Angioqueratoma/diagnóstico , Hemangioma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Piel/citología , Actinas/metabolismo , Anciano , Antígenos CD34/metabolismo , Dermoscopía , Diagnóstico Diferencial , Células Endoteliales/metabolismo , Femenino , Pie , Hemangioma/patología , Hemangioma/cirugía , Hemangioma Cavernoso/diagnóstico , Hemangioma Cavernoso/patología , Humanos , Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo , Piel/patología , UltrasonografíaAsunto(s)
Dermatosis Facial/virología , Rubéola (Sarampión Alemán)/complicaciones , Encefalopatías/virología , Dermatosis Facial/patología , Antebrazo , Hepatitis Viral Humana/virología , Humanos , Linfadenopatía/virología , Masculino , Persona de Mediana Edad , Pancitopenia/virología , Rubéola (Sarampión Alemán)/patología , TóraxRESUMEN
Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies against type XVII collagen/BP180 (BP180). Although the mechanisms of autoantibody production remain to be elucidated, herpes virus infections have been identified as a possible triggering factor for pemphigus. We report a case of herpes zoster (HZ) having anti-BP180 serum antibodies. The patient developed sudden-onset, tense blisters and edematous erythema on the right anterior chest, shoulder and upper back. Histopathology showed remarkable degeneration of keratinocytes, acantholysis and blister formation with ballooning cells, indicating herpes virus infection. A polymerase chain reaction analysis of varicella zoster virus (VZV) was positive in crusts and effusions from the skin lesions, confirming the definitive diagnosis of HZ. Notably, we found that the patient had anti-BP180 serum antibodies in association with the occurrence of HZ. After successful treatment with valacyclovir hydrochloride for 7 days, the serum levels of anti-BP180 antibodies decreased in accordance with the improvement of skin lesions. These findings suggest that the production of anti-BP180 antibodies could be triggered by the reactivation of VZV.
