Genetically determined type 1 diabetes mellitus and risk of osteoporosis.

BACKGROUND: Observational evidence suggests that type 1 diabetes mellitus (T1DM) is associated with the risk of osteoporosis (OP). Nevertheless, it is not apparent whether these correlations indicate a causal relationship. To elucidate the causal relationship, a two-sample Mendelian randomization (MR) analysis was performed. METHODS: T1DM data was obtained from the large genome-wide association study (GWAS), in which 6683 cases and 12,173 controls from 12 European cohorts were involved. Bone mineral density (BMD) samples at four sites were extracted from the GEnetic Factors for OSteoporosis (GEFOS) consortium, including forearm (FA) (n = 8,143), femoral neck (FN) (n = 32,735), lumbar spine (LS) (n = 28,498), and heel (eBMD) (n = 426,824). The former three samples were from mixed populations and the last one was from European. Inverse variance weighting, MR-Egger, and weighted median tests were used to test the causal relationship between T1DM and OP. A series of sensitivity analyses were then conducted to verify the robustness of the results. RESULTS: Twenty-three independent SNPs were associated with FN-BMD and LS-BMD, twenty-seven were associated with FA-BMD, and thirty-one were associated with eBMD. Inverse variance-weighted estimates indicated a causal effect of T1DM on FN-BMD (odds ratio (OR) =1.033, 95 % confidence interval (CI): 1.012-1.054, p = 0.002) and LS-BMD (OR = 1.032, 95 % CI: 1.005-1.060, p = 0.022) on OP risk. Other MR methods, including weighted median and MR-Egger, calculated consistent trends. While no significant causation was found between T1DM and the other sites (FA-BMD: OR = 1.008, 95 % CI: 0.975-1.043, p = 0.632; eBMD: OR = 0.993, 95 % CI: 0.985-1.001, p = 0.106). No significant heterogeneity (except for eBMD) or horizontal pleiotropy was found for instrumental variables, suggesting these results were reliable and robust. CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.

Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.

BACKGROUND: Growing evidence supports an association between physical activity (PA) and the risk of osteoarthritis (OA), but this may be influenced by confounding and reverse causality. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to reveal the causal relationship between PA and OA. METHODS: MR was performed to explore the causation of PA and OA with genetic variants as instrumental variables. The genetic variants were derived from the summary statistics of a large genome-wide association study meta-analysis based on the European population (n = 661,399), including self-reported leisure screen time (LST) and moderate-to-vigorous physical activity (MVPA), and Arthritis Research UK Osteoarthritis Genetics Consortium cohorts (417,596, 393,873 and 403,124 for overall, hip and knee OA, respectively). The major MR analysis used in this work was the inverse variance weighted (IVW) approach, and sensitivity, pleiotropy, and heterogeneity studies were performed to evaluate the validity of the findings. RESULTS: IVW estimates indicated that LST had a risk effect on overall OA (odds ratio (OR) = 1.309, 95% confidence interval (CI): 1.198-1.430, P = 2.330 × 10-9), hip OA (OR = 1.132, 95% CI: 1.009-1.269, P = 0.034) and knee OA (OR = 1.435. 95% CI: 1.286-1.602, P = 1.225 × 10-10). In contrast, no causal relationship was found between MVPA and OA (overall OA: OR = 0.895, 95% CI: 0.664-1.205, P = 0.465; hip OA: OR = 1.189, 95% CI: 0.792-1.786, P = 0.404; knee OA: OR = 0.707, 95% CI: 0.490 -1.021, P = 0.064). In addition, we observed significant heterogeneity in instrumental variables, but no horizontal pleiotropy was detected. CONCLUSIONS: Recent findings demonstrated a protective impact of reducing LST on OA, independent of MVPA. This provides valuable insights into the role of physical activity in OA and offers lifestyle recommendations, such as reducing recreational sedentary behaviors and promoting appropriate exercise, for individuals at risk of OA.

New species and notes on Chinese species of the genus Misolampidius (Coleoptera: Tenebrionidae: Cnodalonini).

A new species of the genus Misolampidius Solsky, 1875, Misolampidius qiaoweipengi sp. nov. from Henan, China, is described. In addition, supplementary descriptions for Misolampidius tentyrioides Solsky, 1876, M. qianshanensis Li, 1992 and M. satoi Masumoto, Akita Utsunomiya, 2003 are provided.

A new species of Hemacroneuria and additions to Chinoperla (Plecoptera: Perlidae) from China.

A new species of Hemacroneuria Enderlein, 1909, H. baotianmana sp. nov. is described and illustrated from Henan Province of central China and Shaanxi Province of northwestern China. Supplementary descriptions and new images are provided for Chinoperla mengmanensis Qian Du, 2012 based on new material from Yunnan Province of southwestern China. The female of C. mengmanensis is described for the first time.

[Variation patterns of soil wall temperature and heat flux in sunken solar greenhouse].

From December 2011 to March 2012, a consecutive test was conducted on the temperature and heat flux of different thickness of the soil backwall of sunken solar greenhouse in Shouguang of Shandong Province, East China, aimed to analyze the variation patterns of soil wall temperature and heat flux of the sunken solar greenhouse and to confirm the suitable wall thickness. In winter, the temperature and heat flux of the wall inner surface and outer surface varied over a wide range, which was in accordance with the variation trend of indoor and outdoor air temperature. Overall, the wall temperature decreased from the inner to the outer surface, and the layers of the inner wall with higher variation range of temperature and heat flux were more than those of the outer wall. The variation range of temperature and heat flux decreased gradually from the shallow layers to deep layers of the wall. In successive cloudy days, the temperature of each layer of inner wall decreased to different degrees, and the layers releasing heat to the indoor deepened constantly, whereas the heat in the layers of outer wall was mainly released to the outdoor. According to the variation patterns of temperature and heat flux in the wall, the wall from inside to outside could be divided into heat storage layer, transitional layer, and cold resistant layer, and their thickness was 0.8-1.0 m, 2.2-2.6 m, and 0.4-0.6 m, respectively, under the condition of the outer surface being covered. Without considering the transitional layer, the suitable thickness of the soil wall in Shouguang solar greenhouse would be 1.4-1.6 m.