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Nat Prod Bioprospect ; 14(1): 37, 2024 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-38861197

RESUMEN

Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural frameworks. The [2 + 2] cycloaddition is unequivocally the primary and most commonly used method for synthesizing cyclobutanes. In this review, we have summarized the application of the [2 + 2] cycloaddition with different reaction mechanisms in the chemical synthesis of selected cyclobutane-containing natural products over the past decade.

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