Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
Virol Sin ; 39(3): 390-402, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38521412

RESUMEN

The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after injury. To address this concern, comparative and systematic analyses of SARS-CoV-2 infection in COVID-19 patients and animals were conducted. In the lungs of nine patients who died of COVID-19 and one recovered from COVID-19 but died of unrelated disease in early 2020, damage-related transient progenitor (DATP) cells expressing CK8 marker proliferated significantly. These CK8+ DATP cells were derived from bronchial CK5+ basal cells. However, they showed different cell fate toward differentiation into type I alveolar cells in the deceased and convalescent patients, respectively. By using a self-limiting hamster infection model mimicking the dynamic process of lung injury remodeling in mild COVID-19 patients, the accumulation and regression of CK8+ cell marker were found to be closely associated with the disease course. Finally, we examined the autopsied lungs of two patients who died of infection by the recent Omicron variant and found that they only exhibited mild pathological injury with no CK8+ cell proliferation. These results indicate a clear pulmonary cell remodeling route and suggest that CK8+ DATP cells play a primary role in mediating alveolar remodeling, highlighting their potential applications as diagnostic markers and therapeutic targets.


Asunto(s)
COVID-19 , SARS-CoV-2 , COVID-19/inmunología , COVID-19/patología , COVID-19/virología , Humanos , Animales , Masculino , Persona de Mediana Edad , Femenino , Cricetinae , Pulmón/patología , Pulmón/virología , Pulmón/inmunología , Adulto , Alveolos Pulmonares/patología , Alveolos Pulmonares/virología , Alveolos Pulmonares/inmunología , Anciano , Modelos Animales de Enfermedad , Lesión Pulmonar/virología , Lesión Pulmonar/patología , Lesión Pulmonar/inmunología , Proliferación Celular , Diferenciación Celular
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...