High-Efficiency Microwave Wireless Power Transmission via Reflective Phase Gradient Metasurfaces and Surface Wave Aggregation.

Microwave Wireless Power Transfer (MWPT) technology is crucial for emergency power supply during natural disasters and powering off-grid equipment. Traditional antenna arrays, however, suffer from low energy capture efficiency, difficult impedance matching, complex synthetic networks, and intricate manufacturing processes. This paper introduces a microwave energy receiver design utilizing Reflective Phase Gradient Metasurfaces (R-PGMs) and surface wave energy convergence technology. The design leverages the effective plane wave-to-surface wave conversion capability of R-PGMs to transform incident microwave energy into a surface wave mode, which is then efficiently harvested using a circular energy convergence array before being output to a coupling port. By optimizing R-PGM parameters, an ideal 60° phase gradient distribution is achieved, facilitating the focus of surface wave energy via dispersion characteristics. These components are integrated into a hybrid antenna array, complemented by a matched energy output port structure. Numerical simulations show that this array can efficiently convert microwave energy from plane waves to surface waves, achieving a conversion efficiency of 85.32% and a collection efficiency of 68.26%. Experimental results corroborate these findings, with peak energy collection efficiency reaching 64.68% at 5.8 GHz and an RF-DC conversion efficiency of 42%, confirming the design's efficacy. Compared to conventional methods, this design simplifies the system by avoiding complex combining networks and significantly enhances the efficiency of microwave MWPT.

TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception.

Efforts on developing transient receptor potential vanilloid 1 (TRPV1) drugs for pain management have been hampered by deleterious hypo- or hyperthermia caused by TRPV1 agonists/antagonists. Here, we compared the effects of four antagonists on TRPV1 polymodal gating and core body temperature (CBT) in Trpv1+/+, Trpv1-/-, and Trpv1T634A/T634A. Neither the effect on proton gating nor drug administration route, hair coverage, CBT rhythmic fluctuations, or inflammation had any influence on the differential actions of TRPV1 drugs on CBT. We identified the S4-S5 linker region exposed to the vanilloid pocket of TRPV1 to be critical for hyperthermia associated with certain TRPV1 antagonists. PSFL2874, a TRPV1 antagonist we discovered, is effective against inflammatory pain but devoid of binding to the S4-S5 linker and inducing CBT changes. These findings implicate that biased allosteric mechanisms exist for TRPV1 coupling to nociception and CBT regulation, opening avenues for the development of non-opioid analgesics without affecting CBT.

Research on the Weighting Values of Community Aging-Friendly Construction Indexes With Different Expert Groups.

The construction of weight values for the indicators of community aging-friendly construction is helpful to guide the formulation of strategies for allocating elderly resources in community aging-friendly constructions, and to reflect the shortcomings of community aging-friendly constructions and propose improvement strategies when evaluating the effectiveness of the existing community aging-friendly constructions. The paper uses the Fuzzy Analytic Hierarchy Process (FAHP) to calculate the weighting values of each indicator, consulting the government, industry, and academic experts. The research results show that the weighting-value order is "public environment (W = 0.364)," "health care (W = 0.342)," "humanistic care (W = 0.204)" and "social economy (W = 0.090)." Accordingly, the article proposes specific suggestions to improve the effectiveness of community aging-friendly constructions, including the need to find consensus among all parties involved in the aging industry, the need to focus on improving the public environment of the community, and the need to improve the socio-economic policies as soon as possible.

Research on the establishment of evaluation index system of the aging construction of the community.

Introduction: Constructing the evaluation index system for the community's aging-friendly construction can provide a decision-making basis for the overall investment and priority satisfaction strategy for the community's aging-friendly construction. Methods: Through questionnaire survey and statistical analysis, this paper evaluates and analyzes the satisfaction level of various indicators of the community's aging-friendly construction. Results: The results show that the community's humanistic care, public environment, and socio-economic criteria are significantly linearly linked to the overall construction satisfaction level. There are significant differences in the general satisfaction level of older adults in the variables of "age, educational background, residence duration, residence personnel, number of children, and marital status". Discussion: To this end, the article concludes with specific recommendations that improving older-adult care services for older adults with low age and high education, helping older adults in the community to familiarize themselves with the community environment as soon as possible, cultivating the professional abilities of community service personnel, reflecting the warmth of the community for older-adult care and improving social security capabilities are the core content of the future community building for aging.

Autophagic regulation of cell growth by altered expression of Beclin 1 in triple-negative breast cancer.

Beclin 1 is a promoter gene for autophagy as well as a key factor for regulating tumor cell growth and death. Allelic deletion of Beclin 1 has been observed in certain triple-negative breat cancer (TNBC) cells, and it might be associated with increased proliferation and invasion in TNBC cells. In this study we investigated the relationship between Beclin 1 expression and prognosis for TNBC patients, as well as the influence on cell growth by Beclin 1 overexpression in different cultural conditions. Beclin 1 expression in TNBC tissues was measured by immunohistochemical staining and correlated with clinicopathologic parameters for TNBC patients. The plasmid of pDS-RED-C1-Beclin 1 was transfected to BT-549 and MDA-MB-231 cells and autophagy, proliferation, apoptosis, cell cycle and Epithelial-mesenchymal transition (EMT) process were measured. Results indicated that high level of Beclin 1 expression was correlated with more lymph nodes and distant metastasis but unrelated to survival rates in 5 years for TNBC patients. In vitro, overexpression of Beclin 1 improved cellular autophagy in both BT-549 and MDA-MB-231 cells, inhibited cell proliferation at normal cultural condition and increased cell survival in starvation, hypoxia or with doxorubicin stimulation. Besides, Beclin 1 overexpression decreased cell apoptosis, induced cells to be in G0/G1 phase and promoted EMT process through Wnt/ß-catenin pathway in starvation. Thus, Beclin 1 overexpression plays a double role in BT-549 and MDA-MB-231 cell growth by elevating the capability of autophagy. These findings might be useful for searching a proper method for clinical therapy of TNBC from the aspect of autophagy in future.

[Establishment of BGC-823/WTX-EGFP gastric cancer cell line stably expressing Wilms tumor gene on X chromosome].

OBJECTIVE: To establish the BGC-823/WTX-EGFP gastric cancer cell line with stable expression of Wilms tumor gene on the X chromosome (MTX) for functional analysis of WTX gene. METHODS: The full-length WTX cDNA was amplified from human embryonic kidney 293FT cells and cloned into the pEGFP-N1 vector containing the reporter gene of green fluorescence protein. The recombinant pEGFP-WTX expression vector, after digestion by restriction enzyme to identify the size of target gene fragment, was transfected into 293FT cells and the expression of fluorescent reporter gene was observed under fluorescence microscope. pEGFP-WTX vector was transfected into human gastric cancer BGC-823 cell line to establish BGC-823/WTX-EGFP cell line stably expressing WTX. Quantitative RT-PCR and immunocytochemical staining were used to detect the expression of WTX in both BGC-823/WTX-EGFP and control BGC-823 cells. RESULTS: The recombinant pEGFP-WTX plasmid was successfully constructed and verified by PCR and sequencing. The mRNA and protein expressions of MTX were significantly increased in BGC-823/WTX-EGFP cells as compared with those in the control cells. CONCLUSION: The full-length WTX expression vector (pEGFP-WTX) and BGC-823/WTX-EGFP gastric cancer cell line have been successfully established to facilitate further functional study of WTX gene.