DDLA: a double deep latent autoencoder for diabetic retinopathy diagnose based on continuous glucose sensors.

The current diagnosis of diabetic retinopathy is based on fundus images and clinical experience. However, considering the ineffectiveness and non-portability of medical devices, we aimed to develop a diagnostic model for diabetic retinopathy based on glucose series data from the wearable continuous glucose monitoring system. Therefore, this study developed a novel method, i.e., double deep latent autoencoder, for exploring glycemic variability influence from multi-day glucose data for diabetic retinopathy. Specifically, the model proposed in this research could encode continuous glucose sensor data with non-continuous and variable length via the integration of a data reorganization module and a novel encoding module with fragmented-missing-wise objective function. Additionally, the model implements a double deep autoencoder, which integrated convolutional neural network, long short-term memory, to jointly capturing the inter-day and intra-day glucose latent features from glucose series. The effectiveness of the proposed model is evaluated through a cross-validation method to clinical datasets of 765 type 2 diabetes patients. The proposed method achieves the highest accuracy value (0.89), precision value (0.88), and F1 score (0.73). The results suggest that our model can be used to remotely diagnose and screen for diabetic retinopathy by learning potential features of glucose series data collected by wearable continuous glucose monitoring systems.

Heart sound classification based on equal scale frequency cepstral coefficients and deep learning.

Heart diseases represent a serious medical condition that can be fatal. Therefore, it is critical to investigate the measures of its early prevention. The Mel-scale frequency cepstral coefficients (MFCC) feature has been widely used in the early diagnosis of heart abnormity and achieved promising results. During feature extraction, the Mel-scale triangular overlapping filter set is applied, which makes the frequency response more in line with the human auditory property. However, the frequency of the heart sound signals has no specific relationship with the human auditory system, which may not be suitable for processing of heart sound signals. To overcome this issue and obtain a more objective feature that can better adapt to practical use, in this work, we propose an equal scale frequency cepstral coefficients (EFCC) feature based on replacing the Mel-scale filter set with a set of equally spaced triangular overlapping filters. We further designed classifiers combining convolutional neural network (CNN), recurrent neural network (RNN) and random forest (RF) layers, which can extract both the spatial and temporal information of the input features. We evaluated the proposed algorithm on our database and the PhysioNet Computational Cardiology (CinC) 2016 Challenge Database. Results from ten-fold cross-validation reveal that the EFCC-based features show considerably better performance and robustness than the MFCC-based features on the task of classifying heart sounds from novel patients. Our algorithm can be further used in wearable medical devices to monitor the heart status of patients in real time with high precision, which is of great clinical importance.

A multiview feature fusion model for heartbeat classification.

Objective.An electrocardiogram (ECG) is one of the most common means to diagnose arrhythmia according to different waveforms clinically. Although there are advanced classification methods such as deep learning, the single view feature cannot meet the demand of classification accuracy for new individuals. To this end, a classification model based on multiview fusion was proposed.Approach.First, handcrafted view features were extracted from heartbeats and then deep view features were obtained from the deep learning model. The features of two different perspectives were fused in the fully connected layer, and the random forest classifier was used instead of the Softmax classifier for classification. Notably, Bayesian optimization was utilized in the hyper-parameter tuning of the classifier. The proposed method employed the MIT-BIH database to classify five classes: normal heartbeat (N), left bundle branch block heartbeat (LB), right bundle branch block heartbeat (RB), atrial premature contraction (APC) and premature ventricular contraction (PVC).Main results.The experimental results achieved a higher average accuracy of 98.93%, average precision of 96.92%, average sensitivity of 96.46%, and average specificity of 99.33% in five types of heartbeat classification for inter-patient.Significance.The proposed framework improves the performance of ECG detection for new individuals. And it provides an feasible algorithmic model for single-lead wearable devices with multiview fusion.