Polarization evolution on higher and hybrid-order Poincaré spheres with coaxial polarization holograms.

Based on the tensor polarization holography theory, we propose a simple and convenient method in the recording material, phenanthrenequinone-doped polymethylmethacrylate, to generate beams on higher and hybrid-order Poincaré spheres, and realize their polarization evolution on the spheres by combining the recorded phase with the Pancharatnam-Berry phase. By simultaneously adjusting the polarization azimuth angle and relative phase of the recorded waves, independent phase-shifts can be imparted onto two orthogonal circular polarization states in reconstruction process of polarization holography. The beams on basic Poincaré sphere are transformed into that on arbitrary higher or hybrid-order Poincaré spheres. We get the Poincaré spheres' type and polarization distribution of the reconstructed wave by interferometry and polarizer, and the results match well with the theoretical predictions.

Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.

Metabolic syndrome (MetS) is a clinical condition associated with multiple metabolic risk factors leading to type 2 diabetes mellitus and other metabolic diseases. Recent evidence suggests that modulating adipose tissue to adaptive thermogenesis may offer therapeutic potential for MetS. Xiasangju (XSJ) is a marketed drug and dietary supplement used for the treatment of metabolic disease with anti-inflammatory activity. This study investigated the therapeutic effects of XSJ and the underlying mechanisms affecting the activation of brown adipose tissue (BAT) in MetS. The results revealed that XSJ ameliorated MetS by enhancing glucose and lipid metabolism, leading to reduced body weight and abdominal circumference, decreased adipose tissue and liver index, and improved blood glucose tolerance. XSJ administration stimulated catecholamine biosynthesis, increasing noradrenaline (NA) levels and activating NA-mediated proteins in BAT. Thus, BAT enhanced thermogenesis and oxidative phosphorylation (OXPHOS). Moreover, XSJ induced changes in gut microbiota composition, with an increase in Oscillibacter abundance and a decrease in Bilophila, Candidatus Stoquefichus, Holdemania, Parasutterella and Rothia. XSJ upregulated the proteins associated with intestinal tight junctions corresponding with lower serum lipopolysaccharide (LPS), tumor necrosis factor α (TNF-α) monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) levels to maintain NA signaling transport. In summary, XSJ may alleviate MetS by promoting thermogenesis in BAT to ultimately boost energy metabolism through increasing NA biosynthesis, strengthening intestinal barrier integrity and reducing low-grade inflammation. These findings suggest XSJ has potential as a natural therapeutic agent for the treatment of MetS.

The oligosaccharides of Xiasangju alleviates dextran sulfate sodium-induced colitis in mice by inhibiting inflammation.

Xiasangju (XSJ) is a traditional Chinese herbal formula consisted of Prunella spica, Mulberry leaf and Chrysanthemi indici flos, which can be used to treat fever, headache and ulcer. To explore the effects of oligosaccharides from XSJ (OX) on colitis, we used dextran sulfate sodium (DSS) to establish colitis mouse models. After administration of OX with different doses on the control and colitis mice, we measured their body weights, disease activity indexes (DAI), lengths and histopathologic changes of colons, spleen indexes. The inflammatory cytokines and oxidative stress-related factors in serum, and the intestinal microbial community in feces were also detected. We found that colitis mice with oral administration of OX showed higher body weights and lower levels of DAI and spleen index. Tissue damages induced by DSS were also alleviated by OX treatment. The colitis mice with OX treatment exhibited lower levels of AST, ALT, BUN, CR, MDA and a down-regulated expression of IL-6 and IL-1ß, while the activity of SOD was up-regulated. Furthermore, OX improved the relative abundance of gut microbiota and restored the proportions of Bacteroidetes and Muribaculaceae. We found that oligosaccharides from XSJ alleviated the symptoms of colitis mice through its inhibitory effects on inflammation and oxidative stress, and also regulated the composition of intestinal flora, which indicates a beneficial role for patients with colitis.

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets.

Weaning stress can induce diarrhea, intestinal damage and flora disorder of piglets, leading to slow growth and even death of piglets. Traditional Chinese medicine residue contains a variety of active ingredients and nutrients, and its resource utilization has always been a headache. Therefore, we aimed to investigate the effects of traditional Chinese medicine residues (Xiasangju, composed of prunellae spica, mulberry leaves, and chrysanthemum indici flos) on growth performance, diarrhea, immune function, and intestinal health in weaned piglets. Forty-eight healthy Duroc× Landrace × Yorkshire castrated males weaned aged 21 days with similar body conditions were randomly divided into 6 groups with eight replicates of one piglet. The control group was fed a basal diet, the antibiotic control group was supplemented with 75 mg/kg chlortetracycline, and the residue treatment groups were supplemented with 0.5%, 1.0%, 2.0% and 4.0% Xiasangju residues. The results showed that dietary Xiasangju residues significantly reduced the average daily feed intake, but reduced the diarrhea score (P < 0.05). The 1.0% and 2.0% Xiasangju residues significantly increased the serum IgM content of piglets, and the 0.5%, 1.0%, 2.0% and 4.0% Xiasangju residues significantly increased the serum IgG content, while the 1.0%, 2.0% and 4.0% Xiasangju residues significantly increased the sIgA content of ileal contents (P < 0.05). Dietary Xiasangju residues significantly increased the villus height and the number of villus goblet cells in the jejunum and ileum, and significantly decreased the crypt depth (P<0.05). The relative mRNA expression of IL-10 in the ileum was significantly increased in the 1% and 2% Xiasangju residues supplemented groups (P < 0.05), while IL-1ß in the ileum was downregulated (P < 0.05). Xiasangju residues improved the gut tight barrier, as evidenced by the enhanced expression of Occludin and ZO-1 in the jejunum and ileum. The diets with 1% Xiasangju residues significantly increased the relative abundance of Lactobacillus johnsonii, and 2% and 4% Xiasangju residues significantly increased the relative abundance of Weissella jogaeotgali (P < 0.05). Dietary supplementation with 0.5%, 1.0%, 2% and 4% with Xiasangju residues significantly decreased the relative abundance of Escherichia coli and Treponema porcinum (P < 0.05). In summary, dietary supplementation with Xiasangju residues improves intestinal health and gut microbiota in weaned piglets.

Scalar vortex beams produced by Pancharatnam-Berry phase optical elements that utilize polarization holography.

We discuss the appearance of the Pancharatnam-Berry phase in polarization holography, and confirm the possibility of generating scalar vortex beams by using the Pancharatnam-Berry phase. The polarization holograms used to generate scalar vortex beams are produced in phenanthrenequinone-doped polymethylmethacrylate (PQ/PMMA), where each radial direction consists of an equivalent half-wave plate hologram with gradually changing directions. The spin angular momentum carried by a circular polarization reading wave is converted into orbital angular momentum in a reconstruction process, resulting in the formation of scalar vortex beams with positive and negative topological charges controlled by the reading polarization.

Polarization splitters with designable separation angles based on polarization holography of tensor theory.

We propose a simple and inexpensive method for the fabrication of polarization splitters with designable separation angles and a controllable active area, based on polarization holography of tensor theory. First, we design two polarization holograms that reconstruct waves with only p- or s-polarization components, respectively. Then, after we recorded these two holograms on the same position of the recording material using the interference approach, as a result, a polarization splitter could readily be prepared. The separation angles of fabricated polarization splitters can be easily adjusted by changing the interference angle, and the active area can also be easily modified by changing the sizes of the interference beams and recording material during the recording process. The experimental results verify the reliability and accuracy of this method. We believe that this work may broaden the application field of polarization holography.

Generation of vector beams based on diffraction characteristics of a linear polarization hologram in coaxial recording.

Polarization holography is an effective tool for realizing light field manipulation and can be utilized to generate vector beams. Based on the diffraction characteristics of a linear polarization hologram in coaxial recording, an approach for generating arbitrary vector beams is proposed. Unlike the previous methods for generating vector beams, in this work, it is independent of faithful reconstruction effect and the arbitrary linear polarization waves can be used as reading waves. The desired generalized vector beam polarization patterns can be adjusted by changing the polarized direction angle of the reading wave. Therefore, it is more flexible than the previously reported methods in generating vector beams. The experimental results are consistent with the theoretical prediction.

An improved strategy for identification and annotation of easily in-sourced dissociation diterpene lactones from plant natural products: Taking Andrographis paniculata (Burm. f.) as an example.

RATIONALE: Diterpene lactones (DL) in Andrographis paniculata (AP) are known as "natural antibiotics" for their excellent antibacterial activity. During mass spectrometry (MS) analysis, the hydroxyl groups in the AP DL skeleton are prone to neutral loss of H2 O, producing high in-source fragment peaks and affecting the characterization of these components. METHODS: Mass tags were applied during the MS data acquisition step, and special adduct ion form was used to guide the data processing and characterization steps. Besides, the total number of characterized AP DLs significantly increased when combining the number of neutrally lost H2 O from AP DLs, incorporating information on the diagnostic ions, and adopting molecular networks generated with the Global Natural Products Social Molecular Networking database. RESULTS: Ninety-nine DLs, comprising 6 monohydroxyl groups, 20 dihydroxyl groups, 27 trihydroxy groups, and 46 DLs with more than 3 hydroxyl groups, were characterized from AP. In addition, based on the characteristic fragments in the product ions (C3 H4 , Δm/z = 40.03 Da), it could be assumed that 90 DLs had the C19-OH structure among the identified DLs. The current study provides a new approach for collecting, processing, and characterizing MS analysis of natural DLs prone to in-source fragmentation. CONCLUSIONS: MS characterization of AP DLs was significantly improved, and many potential new compounds were identified in AP. This characterization provides new methods for the purification and identification of AP DLs.

MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases.

Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy owing to their plasticity and accessibility. They possess several inherent characteristics advantageous for the transplantation-based treatment of neurological disorders, including neural differentiation, immunosuppression, neurotrophy, and safety. However, the therapeutic efficacy of MSCs alone remains unsatisfactory in most cases. To improve some of their abilities, many studies have employed genetic engineering to transfer key genes into MSCs. Both viral and nonviral methods can be used to overexpress therapeutic proteins that complement the inherent properties. However, to date, different modes of gene transfer have specific drawbacks and advantages. In addition, MSCs can be functionalized through targeted gene modification to facilitate neural repair by promoting neural differentiation, enhancing neurotrophic and neuroprotective functions, and increasing survival and homing abilities. The methods of gene transfer and selection of delivered genes still need to be optimized for improved therapeutic and targeting efficacies while minimizing the loss of MSC function. In this review, we focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery genes. Further, we describe the prospects and challenges of their application in animal models of different neurological lesions to broaden treatment alternatives for neurological diseases.

Simultaneously characterized Stokes parameters of a lightwave utilizing the tensor polarization holography theory.

Polarization is a natural property of a lightwave and makes a significant contribution to various scientific and technological applications, due to the different states of polarization (SoP) of a lightwave that may manifest distinct behaviors. Hence, it is important to determine the SoP of the lightwave. Generally, the SoP of a lightwave can be recognized by the Stokes parameters. In this paper, we proposed a novel method to simultaneously characterize the Stokes parameters of a lightwave, by employing the tensor polarization holography theory. This is done through merely a piece of polarization-sensitive material. Compared with the traditional method, this method requires only one measurement to obtain all the Stokes parameters, without using additional polarizing elements. The experimental result shows excellent agreement with the theoretical one, which confirmed the reliability and accuracy of the proposed method. We believe that this work may broaden the application field of polarization holography.

Simple method for generating special beams using polarization holography.

Vector vortex beams are a kind of special beam that simultaneously carry spin and orbital angular momentum. The generation of vector vortex beams usually requires a complex and expensive optical system, which becomes a bottleneck hindering its further application. Thus, a compact, low-cost and efficient special beam generation system is demanded. In this paper, a method that can produce vector vortex beams distributed anywhere in the equator of hybrid-order Poincaré Spheres based on polarization holography is proposed. Via changing some parameters of the device, this method can also produce the scalar vortex beams distributed at any position of the basic Poincaré Sphere and the vector beams distributed at the equator of the higher-order Poincaré Spheres. The work shows that polarization holography has the potential ability to regulate the spin and orbital angular momentum simultaneously, opening a new window for future research and applications of angular momentum space orientation.

Reconstruction characters of conventional holography using polarization-sensitive material.

Polarization holography, recording the amplitude, phase, and polarization of signal wave, may be regarded as the superposition of conventional holography and orthogonal holography. The former implies the signal and reference waves have the identical polarization state in the recording stage, while the latter means that they have the orthogonal polarization state. It is a common sense that in conventional holography, the polarization state of a reconstructed wave is always identical to that of the reading wave. However, predicted by the tensor polarization holography theory, which has been confirmed by many experiments, the polarization state of a reconstructed wave may be different from that of a reading wave. Hence, a question that may arise is which one is correct and why. In this work, we derive the electrical field of a reconstructed wave generated from the hologram that was recorded by the identical elliptically polarized wave at a large angle. The theoretical result shows that there are three kinds of reconstruction characters, and they are confirmed by the designed experiments well. Through the analysis, we find the key to observing that the recording material should be polarization-sensitive; recorded by a nonpolarization sensitive material, the polarization state of the reconstructed wave is always identical to that of the reading wave. The work not only verifies the tensor polarization holography theory, it also enlarges our understanding about conventional holography.

Circular polarization detector based on polarization holography.

We propose and experimentally demonstrate the generation of a circular polarization detector based on planar polarization holography. The detector is designed by constructing the interference field according to the null reconstruction effect. We create multiplexed holograms, which feature the combination of two sets of hologram patterns and operate with opposite circular polarization beams. In a few seconds, the exposure operation allows the polarization multiplexed hologram element to be generated, with functionality equivalent to a chiral hologram. We have theoretically analyzed the feasibility of our scheme and experimentally demonstrated that the right- and left-handed circularly polarized beam can be distinguished directly depending on the different output signals. This work provides a time-saving and cost-effective alternative approach for generating a circular polarization detector and opens avenues for future applications in polarization detection.

Exposure response coefficient of polarization-sensitive media using tensor theory of polarization holography.

We report a method for measuring the exposure response coefficient of polarization-sensitive media using the tensor theory of polarization holography. According to the theory of polarization holography based on the tensor method, the exposure response coefficient of polarization-sensitive media is not only determined by the materials but also affected by the exposure energy. The exposure response coefficient changing with the exposure energy is the key factor in polarization holography for controlling the polarization state of the reconstructed wave. We summarize the change of the polarization state of the reconstructed wave with the exposure energy under different recording conditions and obtain the initial value (about 8.4) of the exposure response coefficient of the polarization-sensitive media. Finally, the null reconstruction of linear polarization wave is realized by using this initial value.

Generation of a vector light field based on polarization holography.

We propose a simple and effective method for generating a vector light field based on the faithful reconstruction (FR) effect of polarization holography, where the arbitrary linear polarization waves can be faithfully reconstructed by the polarization-sensitive recording media. The scheme incorporates the tunable and switchable dynamics exposure system to manufacture vector beams. By regulating the velocity and the initial polarization through the angle-aperture and the half-wave plate in the dynamics exposure system, the generated optical element can convert a linear polarization wave into a vector beam. We have analyzed the feasibility in theory and demonstrated the generation of the vector beams experimentally which shows good agreement with the theoretical simulations.

Significant Enhancement of the Polarization Holographic Performance of Photopolymeric Materials by Introducing Graphene Oxide.

Relying on various defects and functional oxygen-containing groups on the basal planes, graphene oxide (GO) is commonly unitized for intimate mixing with a polymer matrix to fabricate high-performance nanocomposite polymeric materials with the characteristics of graphene. Herein, by introducing GO nanosheets in a phenanthraquinone-doped polymethyl methacrylate (PQ/PMMA) photopolymer, we demonstrate that the polarization holographic diffraction efficiency of nanocomposite materials can be dramatically enhanced up to nearly 10 times and the photosensitivity can also be enhanced by more than 3 times. Experimental observations reveal that the incorporation of GO nanosheets serves as a polymerization initiator not only to promote the polymerization of MMA monomers and induce the drafting behavior of the PMMA polymer on its surface but also to effectively modulate the molecular weight of the PQ/PMMA photopolymer by adjusting the doping concentration of GO nanosheets. The current study, for the first time, demonstrates that the modulation of molecular weight for PQ/PMMA photopolymers here exerts a significant impact on their holography performance. In addition, due to the strong physisorption of PQ photosensitizers onto GO nanosheets, the aggregation of PQ around GO-graft-PMMA also facilitates the formation of GO-graft-PMMA/PQ and is beneficial to the enhancement of holographic performance. The emergence of GO-graft-PMMA/PQ nanocomposite materials here is expected to fulfill the requirement of high-performance polarization-sensitive materials in the field of polarization holographic data storage and provide a facile but effective nanocomposite doping strategy to modulate the holographic performance of photopolymers from micro- and mesoscopic levels.

Faithful reconstruction of linear polarization wave without dielectric tensor constraint.

Faithful reconstruction is a key and crucial point of polarization holography research, and has significant research interests in the field of holographic storage and image display. In order to realize faithful reconstruction of the reconstructed wave, the interference angle and dielectric tensor should be controlled. In contrast, we used the polarization holography theory described by tensor, and obtained the faithful reconstruction condition of linear polarization wave under arbitrary interference angle without any dielectric tensor constraint, which is further verified by experimental analysis.

Generation of circular polarization with an arbitrarily polarized reading wave.

Polarization holography has attracted considerable attention in recent years, due to its capability of recording the polarization information in polarization-sensitive material. Particularly, the faithful reconstruction (FR) can retrieve the polarization information of the recorded signal. To date, studies referring to these topics mainly concentrate on the interference between the same type of polarization such as linearly, circularly, and elliptically polarized light. In addition, most of the reading wave is strictly limited to some specified polarization state to achieve the FR. Here, we apply the linearly polarized light as the reference wave to record the circularly polarized light, and then the circular polarization state would be faithfully reconstructed by the arbitrarily polarized reading wave. We theoretically analyze its polarization characteristic based on the tensor theory and experimentally verified the analytical results. This result further extending the FR in polarization holography, and provides a practicable way to generate circular polarization which is easily fabricated. Moreover, the work would lay a favorable theoretical foundation for the future preparation of circular polarization generator and discloses a new insight in polarization manipulation for tailoring the optical field.

Faithful reconstruction in polarization holography suitable for high-speed recording and reconstructing.

We report on faithful reconstruction in polarization holography independent of the exposure time and the reading wave that is suitable for high-speed recording and reconstructing. Faithful reconstruction, the reconstructed wave being identical to the signal wave, is the basis of the application of polarization holography, which may be applied in many fields. Unfortunately, in many cases, faithful reconstruction depends on the exposure time and the reading wave when phenanthrenequinone-doped polymethyl methacrylate is used as the recording material, and then it is not easy to obtain faithful reconstruction. This limits its application in the field of high-speed recording and reconstructing. Directed by the newly developed tensor polarization holography theory, we report on faithful reconstruction breaking through these limitations. In the recording stage, the signal and reference waves are s- and p- polarized, respectively. In the reconstructing stage, the reading wave is arbitrarily polarized. More importantly, the obtained faithful reconstruction has nothing to do with exposure time and it is time saving. The reported faithful reconstruction would bring great convenience and is suitable for high-speed recording and reconstructing.

Collinear non-interferometric phase retrieval for holographic data storage.

A collinear non-interferometric phase retrieval method for holographic data storage is proposed. The code rate of the collinear system can be increased by 2 times due to transferring the 50% embedded data from a signal beam to a reference beam. Because the reference beam should be always known both in the recording process and reading process, there is no extra material cost for saving the embedded data. Therefore, the storage density of collinear system is increased by about 2 times compared with previous off-axis non-interferometric phase retrieval systems. Besides, we can enhance the algorithm constraint to shorten iteration numbers by increasing the amplitude weight of the reference beam. In the experiment, we shortened the iteration number and the BER by about 3 times. We also find that the reference number can be reduced by using the collinear way and increasing the amplitude weight of reference. This law allows us to give more code positions to signal so that the data amount in one data page can be increased.