1.
Bioorg Med Chem Lett
; 20(17): 5027-30, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20675137
RESUMEN
Pyrrolidine, pyrrolidinone, carbocyclic, and acyclic groups were used as isosteric proline replacements in a series of insulin-like growth factor I receptor kinase/insulin receptor kinase inhibitors. Examples that were similar in potency to proline-containing reference compounds were shown to project a key fluoropyridine amide into a common space, while less potent compounds were not able to do so for reasons of stereochemistry or structural rigidity.