Design and synthesis of novel ß-carboline-bisindole hybrids as potential anticancer agents.

We are reporting a short and convenient pathway for the synthesis of novel ß-carboline-bisindole hybrid compounds from relatively cheap and commercially available chemicals such as tryptamine, dialdehydes and indoles. These newly designed compounds can also be prepared in high yields with the tolerance of many functional groups under mild conditions. Notably, these ß-carboline-bisindole hybrid compounds exhibited some promising applications as anticancer agents against the three common cancer cell lines MCF-7 (breast cancer), SK-LU-1 (lung cancer), and HepG2 (liver cancer). The two best compounds 5b and 5g inhibited the aforementioned cell lines with the same range of the reference Ellipticine at less than 2 µM. A molecular docking study to gain more information about the interactions between the synthesized molecules and the kinase domain of the EGFR was performed. Therefore, this finding can have significant impacts on the development of future research in medicinal chemistry and drug discovery.

Perceptions and experiences of primary healthcare providers toward interprofessional collaboration in chronic disease management in Hue, Vietnam.

In Vietnam, each primary care community health center (CHC) consists of a multi-professional team with six disciplines, including a physician, assistant physician, nurse, pharmacist, midwife, and Vietnamese traditional physician, who are able to meet the majority of patient's needs at the primary care level. How they collaborate, especially in chronic disease management (CDM), is still limited described in the literature. This study aims to gain insight into the perceptions and the experiences of primary health care providers (PHCPs) toward interprofessional collaboration (IPC) in CDM in CHCs in (Hue) Vietnam. A qualitative study of descriptive phenomenology was performed using two focus groups and 15 semi-structured interviews with PHCPs from six professions relevant to CDM in CHCs. The data were analyzed using NVivo 12.0 with a thematic analysis method by a multiprofessional research team. From the analysis, the data were classified into three main themes: "lack of collaborative practice," "knowledge," and "facilitators and barriers to IPC." This study provided evidence of the awareness that actual collaboration in daily care is fragmentarily organized and that PHCPs try to finish their tasks within their profession. PHCPs work multiprofessionally and lack shared decision-making in patient-centered care. There is a need to develop an interprofessional education program and training to address these deficiencies in the Vietnamese context to improve interprofessional collaboration in health care.

Comparison of students' readiness from six health education programs for interprofessional learning in Vietnam: a cross-sectional study.

BACKGROUND: Interprofessional education (IPE) is expected to help prepare undergraduate health profession students to collaborate with other healthcare professionals in realising quality of care. Studies stress the necessity of students' readiness for interprofessional learning (IPL) in view of designing IPE programs. The present study aims to determine students' IPL-readiness and looks at related differences in students enrolled in different programs and at different phases in their educational program. METHODS: A cross-sectional survey study was set up among 1139 students from six health programs at HueUMP, using the Readiness for Interprofessional Learning Scale (RIPLS). Statistical analysis was performed using Kruskal-Wallis H and Mann-Whitney U tests. RESULTS: The overall mean RIPLS score was 68.89. RIPLS scores significantly differed between programs and between phases in the educational programs. Medical students presented a lower readiness level for IPL than students from other programs. In contrast to a significant increase in RIPLS scores of students in the clinical phase in Vietnamese traditional medicine, medicine, and pharmacy, a decrease in RIPLS scores was observed in students in the clinical phase in odonto-stomatology. CONCLUSIONS: The differences could be related to differences in educational programs and the study phases in a particular program. These results offer insights to direct the design and implementation of IPE in health education curricula and especially underscore the need to provide IPE throughout the curriculum.

Metal salt-modified biochars derived from agro-waste for effective congo red dye removal.

Anionic Congo red dye (CR) is not effectively removed by conventional adsorbents. Three novel biochars derived from agro-waste (Acacia auriculiformis), modified with metal salts of FeCl3, AlCl3, and CaCl2 at 500 °C pyrolysis have been developed to enhance CR treatment. These biochars revealed significant differences in effluents compared to BC, which satisfied initial research expectations (P < 0.05). The salt concentration of 2 M realized optimal biochars with the highest CR removal of 96.8%, for AlCl3-biochar and FeCl3-biochar and 70.8% for CaCl2-biochar. The modified biochars were low in the specific surface area (137.25-380.78 m2 g-1) compared normal biochar (393.15 m2 g-1), had more heterogeneous particles and successfully integrated metal oxides on the surface. The CR removal increased with a decrease in pH and increase in biochar dosage, which established an optimal point at an initial loading of 25 mg g-1. Maximum adsorption capacity achieved 130.0, 44.86, and 30.80 mg g-1 for BFe, BCa, and BAl, respectively. As magnetic biochar, which is easily separated from the solution and achieves a high adsorption capacity, FeCl3-biochar is the preferred biochar for CR treatment application.

Vertical flow constructed wetlands using expanded clay and biochar for wastewater remediation: A comparative study and prediction of effluents using machine learning.

This study evaluated and compared the performance of two vertical flow constructed wetlands (VF) using expanded clay (VF1) and biochar (VF2), of which both are low-cost, eco-friendly, and exhibit potentially high adsorption as compared to conventional filter layers. Both VFs achieved relatively high removal for organic matters (i.e. Biological oxygen demand during 5 days, BOD5) and nitrogen, accounting for 9.5 - 10.5 g.BOD5.m-2.d-1 and 3.5 - 3.6 g.NH4-N.m-2.d-1, respectively. The different filter materials did not exert any significant discrepancy to effluent quality in terms of suspended solids, organic matters and NO3-N (P > 0.05), but they did influence NH4-N effluent as evidenced by the removal rate of that by VF1 and VF2 being of 82.4 ± 5.7 and 84.6 ± 6.4%, respectively (P < 0.05). The results obtained from the designed systems were further subject to machine learning to clarify the effecting factors and predict the effluents. The optimal algorithms were random forest, generalized linear model, and support vector machine. The values of the coefficient of determination (R2) and the root mean square error (RMSE) of whole fitting data achieved 74.0% and 5.0 mg.L-1, 80.0% and 0.3 mg.L-1, 90.1% and 2.9 mg.L-1, and 48.5% and 0.5 mg.L-1 for BOD5_VF1, NH4-N_VF1, BOD5_VF2, and NH4-N_VF2, respectively.

Detection of sildenafil adulterated in herbal products using thin layer chromatography combined with surface enhanced Raman spectroscopy: "Double coffee-ring effect" based enhancement.

Sildenafil is an inhibitor of the phosphodiesterase type 5 which is commonly adulterated in herbal health products. In this study, a rapid, sensitive and selective method using thin layer chromatography (TLC) combined with surface-enhanced Raman spectroscopy (SERS) was developed for identification of sildenafil adulteration in herbal drugs and dietary supplements. TLC separation method was developed and different SERS factors were investigated: nanosilver colloid preparation, concentration and volume, and coffee-ring effect (CRE) enhancement for SERS measurement. "Double CRE" - a newly observed effect that resulted in the redistribution of both silver nanoparticles and sildenafil molecules - was reported for the first time in TLC-SERS applications. This method presented an efficient TLC-SERS performance enhanced by the "hot spots" obtained under double CRE. The method was validated in terms of selectivity on three blank matrixes (capsule, granule, and herbal extract) and sensitivity with a limitation of detection (LOD) of 2 ng/spot for sildenafil. The validated method was implemented on 9 herbal products sold on the market as erectile dysfunction therapy. Two products were detected with sildenafil adulteration by the TLC-SERS method and confirmed by parallel LC-MS/MS analysis. These results exhibited the reliability and feasibility of the developed method in adulteration screening for sildenafil. On the other hand, the novel findings on double CRE provided extra information for CRE optimization in TLC-SERS applications.

Real-time 2D parallel windowed Fourier transform for fringe pattern analysis using Graphics Processing Unit.

In optical interferometers, fringe projection systems, and synthetic aperture radars, fringe patterns are common outcomes and usually degraded by unavoidable noises. The presence of noises makes the phase extraction and phase unwrapping challenging. Windowed Fourier transform (WFT) based algorithms have been proven to be effective for fringe pattern analysis to various applications. However, the WFT-based algorithms are computationally expensive, prohibiting them from real-time applications. In this paper, we propose a fast parallel WFT-based library using graphics processing units and computer unified device architecture. Real-time WFT-based algorithms are achieved with 4 frames per second in processing 256x256 fringe patterns. Up to 132x speedup is obtained for WFT-based algorithms using NVIDIA GTX295 graphics card than sequential C in quad-core 2.5GHz Intel(R)Xeon(R) CPU E5420.