[The influence of ceruloplasmin on the rat neocortical ultrastructure in circulatory hypoxia].

Diffuse cerebral ischemia and circulatory hypoxia were modeled by carotid arteries occlusion in 40 white Wistar male rats. The changes of microcirculation bed and neurons of the sensomotor cortical area in hypoxia, preventive and therapeutic regimes of ceruloplasmin injections were compared to the neocortex state of intact rats. The changes of the neocortical ultrastructure established by electron microscopy were characteristic of hypoxic lesions described earlier in the literature. As a result of prolonged administration of ceruloplasmin there was a significant decrease of sensomotor neocortical hypostasis and improvement of microcirculation that suggested its neuroprotective properties.

[The role of cytochrome c in preventing postresuscitation functional disorders of the central nervous system]. / Rol' tsitokhroma c v preduprezhdenii postreanimatsionnykh narushenii funktsional'nogo sostoianiia tsentral'noi nervnoi sistemy.

The effect of intracarotid injection of cytochrome c on the course of the early postresuscitation period was studied in experimental animals (albino rats) after 5-min clinical death from acute blood loss. It was shown that the drug normalizes the disturbed metabolic processes in the brain, reduces the structural changes consequent upon total ischemia, stabilizes the activity of the cardiovascular system and, as a result of this, contributes to restoration of functional activity of the central nervous system in the early postresuscitation period.

[The adaptive-compensatory reactions of the pulmonary microcirculatory bed in experimental pneumonia]. / Prisposobitel'no-kompensatornye reaktsii mikrotsirkuliatornogo rusla legkikh pri éksperimental'noi pnevmonii.

Pulmonary microcirculation was studied in anesthetized interbred male cats with acute pneumonia in acute experiments by the method of intravital microscopy. Due to the reticular structure of the lung microcirculatory channel and the change of the direction of the blood flow in microvessels stretching to the focus of inflammation, collateral circulation developed rapidly and facilitated redistribution of the blood flow in the pulmonary lobe involved in the inflammation.

[The action of prednisolone on external respiratory function in hemorrhagic shock]. / Deistvie prednizolona na funktsiiu vneshnego dykhaniia pri gemorragicheskom shoke.

The dose-dependent effect of prednisolone (30 and 60 mg/kg) on the recovery of the external respiration function and the condition of the lung tissue following hypovolemic hypotension was studied in experiments on dogs. The efficacy of prednisolone (30 mg/kg) for correction of respiratory disorders was shown.

[Morphological changes in the lungs in the early recovery period after clinical death from acute blood loss depending on the method of its compensation]. / Morfologicheskie izmeneniia legkikh v rannem vosstanovitel'nom periode posle klinicheskoi smerti ot ostroi krovopoteri v zavisimosti ot sposoba ee vospolneniia.

Pathomorphological changes in the lungs in the period of clinical death due to acute blood loss and within 1 1/2--2 hours of resuscitation using intraarterial, intravenous, and intraosteal routes for blood loss substitution were studied in dogs. In the period of clinical death significant changes in the lung morphology were observed (capillary plethora, sludge, leukostasis, hemorrhages, fat embolism, irregular aeration of pneumonic tissue), in the early postresuscitation period the intensity of the changes varied in relation to the method of blood loss substitution. The above-mentioned methods are compared.