1.
Dalton Trans
; 50(17): 5779-5783, 2021 May 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33890607
RESUMEN
A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.
