1.
Bioorg Med Chem
; 26(3): 603-608, 2018 02 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29277306
RESUMEN
N-Methyl-d-aspartate (NMDA) receptors have been implicated in learning and memory, and may also play a central role in various conditions leading to neuronal degradation. NMDA receptor antagonists could therefore be of therapeutic benefit for a number of neurological disorders. We have designed hybrid compounds of polyamines and memantine, both of which function as NMDA channel blockers. The triamine derivative with a guanidine moiety showed more potent antagonistic activity than memantine.