2H-2M Phase Control of WSe2 Nanosheets by Se Enrichment Toward Enhanced Electrocatalytic Hydrogen Evolution Reaction.

The phase control of transition metal dichalcogenides (TMDs) is an intriguing approach for tuning the electronic structure toward extensive applications. In this study, WSe2 nanosheets synthesized via a colloidal reaction exhibit a phase conversion from semiconducting 2H to metallic 2M under Se-rich growth conditions (i.e., increasing the concentration of Se precursor or lowering the growth temperature). High-resolution scanning transmission electron microscopy images are used to identify the stacking sequence of the 2M phase, which is distinctive from that of the 1T' phase. First-principles calculations employing various Se-rich models (intercalation and substitution) indicated that Se enrichment induces conversion to the 2M phase. The 2M phase WSe2 nanosheets with the Se excess exhibited enhanced electrocatalytic performance in the hydrogen evolution reaction (HER). In situ X-ray absorption fine structure studies suggested that the excess Se atoms in the 2M phase WSe2 enhanced the HER catalytic activity, which is supported by the Gibbs free energy (ΔGH* ) of H adsorption and the Fermi abundance function. These results provide an appealing strategy for phase control of TMD catalysts.

Highly biocompatible formulations based on Arabic gum Nano composite hydrogels: Fabrication, characterization, and biological investigation.

In the study, fabrication of Arabic gum (AG) hydrogels via reverse micellization method is reported. AG hydrogels were utilized as capping agents to encapsulate zinc sulphide (ZnS), and cadmium sulphide (CdS) nanoparticles via in-situ reduction. Pristine and nanocomposite hydrogels (AG-ZnS and AG-CdS) were characterized through SEM, EDX, TEM, XRD, FTIR, TGA, UV/Visible, and photoluminescence spectroscopy. The hydrogels were subjected to multiple biological assays including antimicrobial, antioxidant, and anti-diabetic formulation, in addition to biocompatibility test. The hydrogels were found to be more effective against bacterial and fungal strains. For instance, AG-ZnS exhibited excellent growth inhibition activity against Escherichia coli (ZoI: 12 ± 1.04 mm) and Candida albicans (35 ± 0.94 mm). Likewise, the nanocomposites hydrogel also displayed excellent DPPH and ABTS free radical scavenging capacity, total antioxidant capacity (TAC), and total reducing power (TRP) ability. Among the hydrogels, AG-ZnS demonstrated considerable α-amylase, and α-glucosidase inhibition potential. Above all, the hydrogels were found highly compatible with human red blood cells (hRBCs). Owing to remarkable antioxidant, antibacterial, antifungal, and bio-compatible nature, the fabricated nanocomposites hydrogels have the potential to be explored in tissue engineering, wound healing, drug delivery, and in environmentally friendly hygiene products.

Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.

We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application. High yield of spherical GA microgels particles within 5-50 µm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium. The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively. Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed. Pristine GA microgels, and the nanocomposite microgels were thoroughly characterized through FTIR, DSC, TGA, XRD, SEM, EDS, and TEM. The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation. Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels. Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 µg ml-1 and 343 µg ml-1 , respectively. Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively. Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels. A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.