1.
Org Lett
; 24(1): 369-373, 2022 01 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34918939
RESUMEN
A synthetic method for the synthesis of a highly congested α,ß-dehydroamino acid through the ß-C-H bond activation of an amino acid Schiff base is described. Abundant hydrocarbon feedstock could be used as an alkylating reagent to afford an α,ß-dehydroamino acid bearing a quaternary carbon at the γ-position with an exclusively (Z)-geometry. Notably, a tetrasubstituted olefin could be constructed from saturated starting materials. The transformation of the synthesized α,ß-dehydroamino acid into unnatural α-amino acid derivatives was also demonstrated.